Mineralized Collagen Bone Graft Substitutes PDF Download

Author: Xiu-Mei Wang
Publisher: Woodhead Publishing
ISBN: 0081027397
Category : Medical
Languages : en
Pages : 258

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Book Description
Mineralized Collagen Bone Graft Substitutes presents a comprehensive study of biomimetic mineralized collagen, synthesized in vitro, a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the clinical use of this novel material, the book provides a complete examination, from bench to bedside. Chapters discuss natural bone and familiar biomaterials for bone repair, the preparation and safety of mineralized collagen, products made of mineralized collagen, and present clinical case studies. This book is an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. Provides a deep analysis of synthetic collagen, from bench to bedside Systematically examines the structure, principles, properties, biomimetic synthesis and characterization of mineralized collagen for bone repair Includes case studies that look at a range of clinical bone repair applications of Mineralized collagen and their clinical results

Author: Cato T. Laurencin
Publisher: ASTM International
ISBN: 2003620036
Category :
Languages : en
Pages : 323

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Book Description

Author: Abdul Aziz Nather
Publisher: World Scientific
ISBN: 9814481475
Category : Medical
Languages : en
Pages : 612

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Book Description
This book provides the latest updates on the major challenges of bridging large bone defects, where options range from autografts, “tissue engineered bone”, biomaterials (hydroxyapatite, polycaprolactone and third generation biomaterials) to prostheses. Emphasis has been made on bone tissue engineering, the current state-of-the-art in this field, problems encountered with cell culture technology, scaffolds and bone growth factors (including genomics) and the use of gene therapy for the application of bone growth factors. Attention has also been given to the use of bone autografts. It also covers the use of biomaterials and prostheses as other options for reconstruction. Clinical applications, in addition to the basic science, are also included throughout the discussions.

Author: Kwok-Ming Chan
Publisher: Open Dissertation Press
ISBN: 9781361318546
Category :
Languages : en
Pages :

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Book Description
This dissertation, "To Develop a Transplantable Viable Construct for the Patching of a Bone Defect: a New Bone Graft Substitute by Means of Tissue Engineering" by Kwok-ming, Chan, 陳國明, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Bone grafting is an integral part of reconstructive surgery. In the United States alone over 250,000 bone grafts were harvested annually. While autogenic bone grafting has always been associated with donor site morbidity, bone graft substitutes have been suggested as a solution. In this project, a bone graft substitute using human dental pulp cells (HDPCs) and peptide nanofibre hydrogel was being developed. HDPCs were isolated from extracted teeth. After culture and expansion, unsorted HDPCs were encapsulated into peptide nanofibre hydrogel. These cell-gel constructs were cultured for two weeks in ordinary culture medium and then for 2-3 more weeks in osteogenic lineage induction medium. The post-induced cell-gel derived constructs were transplanted into skin pouches or calvarial bone defects of nude mice. When transplanted subcutaneously, the cell-gel derived constructs were harvested at four to twelve weeks postoperatively (n=5). Tissue samples were processed for contact radiograph, histological examination and antibody staining. These constructs developed into vascularised, mineralised tissue pieces. Though bone marker proteins (osteopontin, osteocalcin and osteonectin) were detected in these tissue pieces, the histological structure of their tissue matrix did not resemble bone matrix. Later, it was accidentally noted that portions of constructs touching the bone defect margin, would form bone through direct matrix transformation. This indicated that the current cell-gel model was potentially the first study model of tissue engineering bone by simulating intramembranous ossification. In the bone defect trial, obviously mineralized cell-gel derived constructs of matching shape and size were selected to patch the 3mm calvarial bone defects (n=5). Bone defect specimens were harvested at two weeks post-operation. The development of radio-opaque structures within the bone defects were evaluated in virtual 3-dimensional models constructed with data collected by microtomographic scanning. The bone nature of these radio-opaque structure were validated histologically (by staining with Hematoxylin and Eosin, Periodic acid-Schiff stain and Picrosirius red) and immunologically (with antibody against human collagen-I, osteonectin and parathyroid hormone receptor). The radio-opaque structures developed into the bone defect were evaluated positive for bone. And significantly more bone regeneration was observed in the test group (n=4) than in the control (n=2). The mean area percentages of regeneration were 46.3% and 0% respectively (pWhile the majority of studies in bone tissue engineering have worked with bone marrow stromal cells and scaffolds of synthetic polymer or calcium based materials, this is the first successful attempt of using HDPCs and peptide nanofibre hydrogel to engineer bone (in a nude mice mode). And the potential of these cell-gel derived constructs to promote bone regeneration was demonstrated. But this was the result from a single experiment of small sample size in one animal model only. It needs to be fortified by further experiments with larger population size and in other animal models. To increase clinical usefulness, the construct will need to be scaled up to centimetre size level. This will necessitate a change of its configuration from bead into meshw

Author: Brandy Rogers Adams
Publisher:
ISBN:
Category : Biomedical materials
Languages : en
Pages :

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Book Description
Bone consists of collagen/hydroxyapatite (HA) composites in which poorly crystalline carbonated calcium phosphate is intercalated within the fibrillar structure. Normal bone mineral is a carbonated-apatite, but there are limited data on the effect of mineral containing carbonate on cell response. Although the exact biological role of silicate in bone formation is unclear, silicate has been identified at trace levels in immature bone and is believed to play a metabolic role in new bone formation. To mimic the inorganic and organic composition of bone we have developed a variety of bone graft substitutes. In the present body of research, we characterized the surface composition of human cortical and trabecular bone. When then characterized the surface compositions of the following potential bone substitutes: carbonated hydroxyapatite (CO32-HA), silicated hydroxyapatite (Si-HA), and collagen sponges mineralized with calcium phosphate using the polymer-induced liquid-precursor (PILP) process. In the latter substitutes, the PILP process leads to type I collagen fibrils infiltrated with an amorphous mineral precursor upon which crystallization leads to intrafibrillar HA closely mimicking physiological bone mineral. We then determined the osteoblast-like cell response to each bone substitute to characterize the substrate's effect on osteoblast differentiation. The observations collectively indicate that cells are sensitive to the formatting of the mineral phase of a bone substitute and that this format can be altered to modulate cell behavior.

Author: Jeffrey O. Hollinger
Publisher: CRC Press
ISBN: 1135501912
Category : Medical
Languages : en
Pages : 500

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Book Description
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Author: Terrance D. Peabody
Publisher: Springer
ISBN: 3319073230
Category : Medical
Languages : en
Pages : 224

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Book Description
This text provides a comprehensive overview of orthopaedic oncology – the field of orthopaedic surgery that specializes in the evaluation and treatment of bone and soft tissue tumors of the musculoskeletal system. The opening chapters cover musculoskeletal imaging interpretation and the principles of musculoskeletal biopsy. Assessment and treatment of the full range of tumors are then described in a series of well-illustrated chapters. Detailed consideration is given to benign tumors, osteosarcomas, Ewing sarcomas, chondrosarcomas, metastatic bone disease of the axial and appendicular skeleton, and soft tissue sarcomas. This book will be invaluable for both orthopaedic surgeons and medical oncologists, providing a framework for understanding the fundamentals of these tumors and a sound basis for their treatment.

Author: Mutaz B. Habal
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 504

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Book Description
Edited by a recognized authority in craniofacial surgery, this book provides comprehensive coverage of bone grafts and substitutes. International contributors discuss the basic science of bone graft healing, including different forms of bone grafts, applications by surgical subspecialty, radiographic assessment, critical sites for new bone formation, and more. Plus, contains clinical and research-oriented information on bone substitutes, including composite grafts, metallic implants, implant interface, computer-assisted fabrication of bone grafts, and much more.

Author: Ilser Turkyilmaz
Publisher: BoD – Books on Demand
ISBN: 9535117416
Category : Medical
Languages : en
Pages : 278

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Book Description
Implant dentistry has changed and enhanced significantly since the introduction of osseointegration concept with dental implants. Because the benefits of therapy became apparent, implant treatment earned a widespread acceptance. Therefore, the need for dental implants has caused a rapid expansion of the market worldwide. Dental implantology continues to excel with the developments of new surgical and prosthodontic techniques, and armamentarium. The purpose of this book named Current Concepts in Dental Implantology is to present a novel resource for dentists who want to replace missing teeth with dental implants. It is a carefully organized book, which blends basic science, clinical experience, and current and future concepts. This book includes ten chapters and our aim is to provide a valuable source for dental students, post-graduate residents and clinicians who want to know more about dental implants.

Author: Sergey V. Dorozhkin
Publisher: CRC Press
ISBN: 9814364177
Category : Science
Languages : en
Pages : 863

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Book Description
Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha