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Author: Gregory A Hudalla Publisher: Royal Society of Chemistry ISBN: 178801815X Category : Technology & Engineering Languages : en Pages : 422
Book Description
The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles. The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.
Author: Gregory A Hudalla Publisher: Royal Society of Chemistry ISBN: 178801815X Category : Technology & Engineering Languages : en Pages : 422
Book Description
The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles. The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.
Author: Mario Barbosa Publisher: Woodhead Publishing ISBN: 008100852X Category : Technology & Engineering Languages : en Pages : 390
Book Description
Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers
Author: Francesco Travascio Publisher: BoD – Books on Demand ISBN: 9535124153 Category : Science Languages : en Pages : 376
Book Description
The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.
Author: Xiaoming Li Publisher: Springer Nature ISBN: 9813369620 Category : Medical Languages : en Pages : 517
Book Description
This book will consist of 8 chapters, in which important issues regarding decellularized materials (DMs) will be discussed. This book will provide special knowledge of materials for the persons with biomedical background, and special biomedical knowledge for the persons with the background of materials, which will hopefully become a valuable informative read for the researchers and students of biomedical engineering major.
Author: Edgardo Abelardo Dohns Publisher: ISBN: Category : Languages : en Pages :
Book Description
Rationally designed polypeptide-based materials have advantages over other biomaterials for their ability to be engineered from the bottom-up, and to be tailored to the needs of specific potential applications. Based on previous works in the Woolfson laboratory on self- assembling peptide fibres (SAF), this research project focused on developing coiled-coil- based fibrillar hydrogel networks called hydrogelating SAFs (hSAFs), and applying them to more-complex biological systems, notably in cell culture. The hSAFs were tested as a three- dimensional cell-culture scaffold with the aim of mimicking the microenvironment provided by native extracellular matrix (ECM). hSAFs were shown to support growth and differentiation of neuronal cells. Furthermore, a design strategy was explored on how to couple short biomimetic peptides to these proteinogenic scaffolds to enhance cell-matrix interactions. This was achieved by integrating the well-studied cell-adhesion motif RGDS (Arg-Gly-Asp- Ser) to hSAFs using bioorthogonal copper-based click chemistry. Addition of such biomimetic peptides did not alter folding, fibre formation, and higher-order assembly (gelation) of the hSAFs. The resulting functionalised gels promoted early differentiation and longer neurite-like outgrowth in PC12 cells, and of primary rat hippocampal cells. The attached biomimetic peptide was functional and elicited the desired cellular response. Another short biomimetic peptides, i.e. the laminin-derived IKVAV (lIe-Lys-Val-Ala-Val), which supports neurite growth, was also successfully incorporated into hSAFs and gels. Thus, we have demonstrated a chemically defined, bottom-up approach to biological scaffold synthesis and assembly, and further the use of straightforward techniques to incorporate specific biomolecular signals under physiological conditions. Although conditions will need to be optimised for different cell types, hSAF gel formation and functionalisation via click chemistry promise a robust platform in cell-culture studies and potentially for tissue engineering.
Author: Corinne Nardin Publisher: John Wiley & Sons ISBN: 3527810994 Category : Technology & Engineering Languages : en Pages : 288
Book Description
Biological Soft Matter Explore a comprehensive, one-stop reference on biological soft matter written and edited by leading voices in the field Biological Soft Matter: Fundamentals, Properties and Applications delivers a unique and indispensable compilation of up-to-date knowledge and material on biological soft matter. The book presents a thorough overview about biological soft matter, beginning with different substance classes, including proteins, nucleic acids, lipids, and polysaccharides. It goes on to describe a variety of superstructures and aggregated and how they are formed by self-assembly processes like protein folding or crystallization. The distinguished editors have included materials with a special emphasis on macromolecular assembly, including how it applies to lipid membranes, and proteins fibrillization. Biological Soft Matter is a crucial resource for anyone working in the field, compiling information about all important substance classes and their respective roles in forming superstructures. The book is ideal for beginners and experts alike and makes the perfect guide for chemists, physicists, and life scientists with an interest in the area. Readers will also benefit from the inclusion of: An introduction to DNA nano-engineering and DNA-driven nanoparticle assembly Explorations of polysaccharides and glycoproteins, engineered biopolymers, and engineered hydrogels Discussions of macromolecular assemblies, including liquid membranes and small molecule inhibitors for amyloid aggregation A treatment of inorganic nanomaterials as promoters and inhibitors of amyloid fibril formation An examination of a wide variety of natural and artificial polymers Perfect for materials scientists, biochemists, polymer chemists, and protein chemists, Biological Soft Matter: Fundamentals, Properties and Applications will also earn a place in the libraries of biophysicists and physical chemists seeking a one-stop reference summarizing the rapidly evolving topic of biological soft matter.
Author: Wolfgang Holnthoner Publisher: Springer ISBN: 9783319545844 Category : Technology & Engineering Languages : en Pages : 0
Book Description
This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.
Author: Shay Soker Publisher: Humana Press ISBN: 3319605119 Category : Medical Languages : en Pages : 213
Book Description
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Author: Jeffrey O. Hollinger Publisher: CRC Press ISBN: 1135501912 Category : Medical Languages : en Pages : 500
Book Description
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Author: Thimmaiah Govindaraju Publisher: Springer Nature ISBN: 9811641897 Category : Technology & Engineering Languages : en Pages : 545
Book Description
This book is the ultimate assembly of recent research activities on molecular architectonics and nanoarchitectonics by authors who are worldwide experts. The book proposes new ways of creating functional materials at the nano level using the concepts of molecular architectonics and nanoarchitectonics, which are expected to be the next-generation approaches beyond conventional nanotechnology. All the contents are categorized by types of materials, organic materials, biomaterials, and nanomaterials. For that reason, non-specialists including graduate and undergraduate students can start reading the book from any points they would like. Cutting-edge trends in nanotechnology and material sciences are easily visible in the contents of the book, which is highly useful for both students and experimental materials scientists.
Author: Gregory A Hudalla
Author: Gregory A Hudalla
Author: Mario Barbosa
Author: Francesco Travascio
Author: Xiaoming Li
Author: Edgardo Abelardo Dohns
Author: Corinne Nardin
Author: Wolfgang Holnthoner
Author: Shay Soker
Author: Jeffrey O. Hollinger
Author: Thimmaiah Govindaraju