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Author: Roger Evans Publisher: Nova Science Publishers ISBN: 9781634833332 Category : Dehydrogenases Languages : en Pages : 0
Book Description
Methylenetetrahydrofolate Reductase (MTHFR) is a key enzyme involved in the folate pathway. Folate, a water soluble B vitamin, naturally present in fruits and vegetables, is a critical methyl donor for several molecular pathways necessary for cellular replication and maintenance. The authors of this book examine the importance of MTHFR in health and disease, including the folate requirements in healthy young women and its potential health implications and the role folate deficiency and MTHFR polymorphisms may play in the complex mechanism of global DNA hypomethylation. Other chapters explore and describe literature data on the involvement of MTHFR gene in HNC development and treatment outcomes and the role of MTHFR and other enzymes in the circulation of methyl in certain neurodegenerative diseases.
Author: Roger Evans Publisher: Nova Science Publishers ISBN: 9781634833332 Category : Dehydrogenases Languages : en Pages : 0
Book Description
Methylenetetrahydrofolate Reductase (MTHFR) is a key enzyme involved in the folate pathway. Folate, a water soluble B vitamin, naturally present in fruits and vegetables, is a critical methyl donor for several molecular pathways necessary for cellular replication and maintenance. The authors of this book examine the importance of MTHFR in health and disease, including the folate requirements in healthy young women and its potential health implications and the role folate deficiency and MTHFR polymorphisms may play in the complex mechanism of global DNA hypomethylation. Other chapters explore and describe literature data on the involvement of MTHFR gene in HNC development and treatment outcomes and the role of MTHFR and other enzymes in the circulation of methyl in certain neurodegenerative diseases.
Author: Per Magne Ueland Publisher: CRC Press ISBN: 1498713882 Category : Medical Languages : en Pages : 225
Book Description
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in both folate and homocysteine metabolism. It first achieved medical recognition in 1972 with the report of severe deficiency of MTHFR in a patient with homocystinuria, an inborn error of metabolism characterized by marked elevation of homocyst(e)ine in plasma and urine. Although the majority of cases of homocystinuria are due to a deficiency of the first enzyme in the transsulfuration pathway for homocysteine metabolism, cystathionine-ß-synthase (CBS), disruption of homocysteine remethylation to methionine can also result in homocystinuria. With the identification of additional patients with severe MTHFR deficiency, the heterogeneity of this disorder became manifest. This book covers many of the complex traits that have been reported to be influenced by the well-characterized 677C→T variant; there is less information on the 1298A→C variant, but it is discussed where appropriate. It is quite surprising, and unique, that a single variant should influence such a wide variety of clinical conditions.
Author: Jeffrey Winzant Publisher: No Fluff Publishing ISBN: Category : Health & Fitness Languages : en Pages : 101
Book Description
If you've been following the health and wellness scene at all in recent years, you've likely heard about MTHFR, even if you've never heard of the gene by that name. MTHFR is an abbreviation for methylenetetrahydrofolate reductase, an enzyme that plays a key role in converting folic acid into folinic acid and methionine, two chemicals used throughout the body. Folic acid is the synthetic form of folate, which is naturally found in foods. While you can't control whether or not you inherited this gene mutation, it's still important to know about it. A lack of enzymes can be associated with various diseases and disorders such as cancer, vascular disease, and many more. If your MTHFR gene is defective, it can cause a variety of health problems. A recent study published in the journal Nutrients found that people with MTHFR gene defects are more likely to have problems with obesity, insulin resistance, and fatty liver disease. The study authors suggest that people with MTHFR gene defects might benefit from a diet that is lower in sugar and saturated fat and higher in fiber. Luckily, there are ways to work around these problems. One of the most popular methods is to follow a special MTHFR diet. This diet focuses on eating foods that are high in folate and other nutrients that support MTHFR function. It also recommends avoiding foods that can interfere with folate absorption, such as sugar and saturated fat. If you're interested in trying the MTHFR diet, this guide will show you how to get started. In this guide, you will discover... What the MTHFR diet is The benefits of following an MTHFR diet How to follow an MTHFR diet Sample recipes for the MTHFR diet
Author: Robin Terranella Publisher: ISBN: 9781977081568 Category : DNA Languages : en Pages : 63
Book Description
"Have you been struggling with health issues for years and recently diagnosed with MTHFR? You've identified the cause of your health issues, but are still unsure what to do next? Dr. Terranella has treated hundreds of MTHFR cases over the years and now has released a comprehensive guide to help you navigate MTHFR treatment. Go beyond just learning about MTHFR gene mutation and actually address your individual treatment options. Rather than a one size fits all protocol, Dr. Terranella provides you with the 'why' behind the what to do, what to expect, and what to do when things do not go as planned." --
Author: Charles R. Scriver Publisher: New York ; Montreal : McGraw-Hill ISBN: 9780071363198 Category : Genetic disorders Languages : en Pages : 6338
Book Description
Presents clinical, biochemical, and genetic information concerning those metabolic anomalies grouped under inborn errors of metabolism.
Author: K. Robinson Publisher: Springer Science & Business Media ISBN: 9780792362487 Category : Medical Languages : en Pages : 480
Book Description
This state-of-the-art review provides an in-depth and critical summary of homocysteine from its molecular basis to clinical relevance and current clinical trials of folic acid and vitamin B6. Written by leading workers in the field, the book provides an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians and any others engaged in the field. It will also be useful to anyone involved in managing vascular patients or cardiac risk factors, as well as biochemists, pharmacologists, general physicians, cardiologists and clinical and basic researchers with an interest in preventive medicine.
Author: Astrid Sigel Publisher: Springer Science & Business Media ISBN: 9400775008 Category : Science Languages : en Pages : 603
Book Description
MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.
Author: Brendan Lee Publisher: Oxford Monographs on Medical G ISBN: 0199797587 Category : Medical Languages : en Pages : 393
Book Description
This volume is an expansion on the known treatment model of IEMs, one that establishes an innovative pathway approach and provides a new authority on this family of disease. Alongside the standard cadre of molecular and clinical underpinnings, this book includes coverage of newborn screening and an overarching treatment of IEMs as complex diseases.
Author: Roger Evans
Author: Roger Evans
Author: Per Magne Ueland
Author: Jeffrey Winzant
Author: Robin Terranella
Author: Charles R. Scriver
Author: Ralph Carmel
Author: K. Robinson
Author: 
Author: Astrid Sigel
Author: Brendan Lee