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Author: Arnold Schwartz Publisher: Springer ISBN: 9781461574279 Category : Medical Languages : en Pages : 585
Book Description
The death of Sir Henry Hallett Dale two years ago brought to a close an era which was characterized by tremendous pharmacologic advancements. During this period, the employment of what present investigators might consider "primitive" techniques yielded information which has become classic. For example, in a paper by Barger and Dale, published in 1910*, one finds not only a beautiful example of a structure-activity study and suggestions of the importance of membranes, but also the concept of specific receptor sites introduced by the statement that "the relation of the receptive mechanism to the base (i. e. , drug base) may well be one of solid solution of adsorption, and, therefore, more analogous to that of an enzyme to its substrate . . . " The search for drug receptors continues today at an accelerated pace. Hopefully, fundamental knowledge of receptors and the nature of drug-receptor interactions will lead to a rational approach to drug design. In acquiring skills in the scientific approach to drug mechanism and evaluation, the modern pharmacologist, whether senior investigator or student, frequently is re quired to employ techniques which are characteristic of other biologic areas. However, it is not enough simply to be grounded in physiology or biochemistry.
Author: Robert Turner Publisher: Elsevier ISBN: 1483264238 Category : Medical Languages : en Pages : 309
Book Description
Screening Methods in Pharmacology, Volume II is a collection of papers that presents practical techniques and information on the selection of a screening program for a particular pharmacological activity. The book contains the most reliable, simplest, and the most preferred screening methods in pharmacology. The text presents screening methods for alpha and beta Adrenergic blocking agents; compounds for antianginal activity; topical products for excessive eccrine sweating; antidepressant agents; and agents with analgesic and analgesic antagonist activity. Pharmacologists, pharmacists, researchers, and physicians will find this book a good source of information.
Author: H.Gerhard Vogel Publisher: Springer Science & Business Media ISBN: 3540898905 Category : Medical Languages : en Pages : 576
Book Description
Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
Author: Jose V. Castell Publisher: Elsevier ISBN: 0080534600 Category : Medical Languages : en Pages : 483
Book Description
In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies. Meets the continuing demand for information in this field Compares In Vitro techniques with other methods Describes cell-culture methods used to investigate toxicity in cells derived from different organs Includes contributions by leading experts in the field
Author: Irving Wainer Publisher: CRC Press ISBN: 9780824788193 Category : Science Languages : en Pages : 450
Book Description
Maintaining and enhancing its focus on key issues in the development, regulatory approval and use of stereoisomeric compounds, this edition continues to cover in detail all aspects of chiral drugs from the academic, governmental, industrial and clinical points of view.;Completely rewritten and updated throughout, Drug Stereochemistry: illustrates current indirect chromatographic methods for the resolution of drug enantiomers; treats the rapidly growing area of enantioselective gas chromatography; discusses the latest in HPLC resolution of enantiomeric drugs; uses verapamil as a model to show how stereoselective pharmacokinetics affect pharmacodynamics; and supplies an in-depth study on the effect of stereoselective plasma protein binding.;This edition offers entirely new chapters that: discuss the recent decisions and present position of the US Food and Drug Administration on the development of stereoisomeric drugs; explicate enzymatic synthesis of stereochemically pure drugs; review the toxicological, pharmacokinetic and pharmacodynamic differences found among stereoisomers; elucidate the stereoselective transport of drugs across epithelia; and give a physician's perspective on the questions and problems caused by stereoisomeric drugs in practice as well as the pharmaceutical industry's collective viewpoint based on a national survey.
Author: Adam LaCaze Publisher: Springer Nature ISBN: 3030291790 Category : Medical Languages : en Pages : 470
Book Description
This volume covers a wide range of topics concerning methodological, epistemological, and regulatory-ethical issues around pharmacology. The book focuses in particular on the diverse sources of uncertainty, the different kinds of uncertainty that there are, and the diverse ways in which these uncertainties are (or could be) addressed. Compared with the more basic sciences, such as chemistry or biology, pharmacology works across diverse observable levels of reality: although the first step in the causal chain leading to the therapeutic outcome takes place at the biochemical level, the end-effect is a clinically observable result—which is influenced not only by biological actions, but also psychological and social phenomena. Issues of causality and evidence must be treated with these specific aspects in mind. In covering these issues, the book opens up a common domain of investigation which intersects the deeply intertwined dimensions of pharmacological research, pharmaceutical regulation and the related economic environment. The book is a collective endeavour with in-depth contributions from experts in pharmacology, philosophy of medicine, statistics, scientific methodology, formal and social epistemology, working in constant dialogue across disciplinary boundaries.
Author: Terry Kenakin Publisher: Academic Press ISBN: 0128139587 Category : Medical Languages : en Pages : 488
Book Description
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
Author: N. S. Parmar Publisher: Alpha Science International, Limited ISBN: 9781842653463 Category : Animal experimentation Languages : en Pages : 452
Book Description
Screening Methods in Pharmacology provides an up to-date and concise account of in vivo methods used in the pharmacological screening of important categories of clinically useful drugs. It also encompasses the basic principles of animal experimentation and current advances leading to the use of transgenic animals, combinatorial chemistry, high throughout screening, pharmacogenomics, proteomics and array technology. The methods used for the detection of pharmacological effects of potential drugs on the CNS, CVS, endocrines, respiratory tract and immunomodulation have been described in adequate details with cross references for further studies and comprehension. The book is expected to be extremely useful for postgraduates in pharmacology from all disciplines and for the scientists engaged in the drug discovery research programmes.
Author: Arnold Schwartz
Author: Robert Turner
Author: H.Gerhard Vogel
Author: 
Author: Jose V. Castell
Author: Robert Arnold Turner
Author: Irving Wainer
Author: Adam LaCaze
Author: Terry Kenakin
Author: Robert A. Turner
Author: N. S. Parmar