Author: A. R. MattocksPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 424
Book Description
Chemistry and Toxicology of Pyrrolizidine Alkaloids
Author: A. R. MattocksPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 424
Book Description
The Pyrrolizidine Alkaloids
Author: Pak Sin ChuMetabolism of Pyrrolizidine Alkaloids
Author: David Felt EastmanMetabolism of Pyrrolizidine Alkaloids by Ruminal Microbes
Author: Jeannette Talbot HovermalePublisher:
ISBN:
Category : Pyrrolizidines
Languages : en
Pages : 250
Book Description
A Study of the Metabolism of Pyrrolizidine Alkaloids in Guinea Pig and Rat
Author: Stephen Randall DuekerPublisher:
ISBN:
Category :
Languages : en
Pages : 294
Book Description
Pyrrolizidine Alkaloids Health and Safety Guide
Author: International Program on Chemical SafetyPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 24
Book Description
This is a companion volume to Environmental Health Criteria 80: Pyrrolizidine alkaloids. Published by WHO for the International Programme on Chemical Safety, (a collaborative programme of UNEP, ILO and WHO)
Pyrrolizidine Alkaloids
Author: Helmut WiedenfeldPublisher: Vandenhoeck & Ruprecht
ISBN: 3899714261
Category : Pyrrolizidines
Languages : de
Pages : 145
Book Description
Pyrrolizidine alkaloids show only minor toxicity in their native state, but are metabolized in the human or animal organisms to carcinogenic, teratogenic and mutagenic compounds, with the precise structure of these compounds being responsible for the metabolic toxification process. Therefore, to be able to evaluate the toxic potential of each alkaloid, it is essential to exactly know the structure of the respective compound. X-ray structure analysis is the appropriate method both for elucidating the structure and for determining other parameters, such as the lengths of the bonds that influence the metabolic process. This book describes the incidence and the process of the intoxication as well as the possibilities to how the substances may reach the organism. In addition, the compounds elucidated by X-ray structure analysis to date are shown in their three-dimensional structure and structure-toxicity relationships are discussed.Pyrrolizidinalkaloide weisen in nativem Zustand nur geringe Toxizität auf, werden jedoch zu kanzerogenen, teratogenen und mutagenen Verbindungen metabolisiert, wenn sie in den menschlichen oder tierischen Organismus gelangen. Der Verlauf dieser Toxifizierung hängt von der konkreten Struktur dieser Stoffe und weiteren Parametern ab. Zur Bestimmung dieser Faktoren stellt die Röntgenstrukturanalyse die geeignete Methode dar. Im vorliegenden Buch werden das Vorkommen, der Ablauf der Toxifizierung und die Möglichkeiten, wie die Stoffe in den Organismus gelangen können, beschrieben. Es werden die bislang durch Röntgenstrukturanalyse vermessenen Verbindungen in ihrer 3D-Struktur aufgefÃ"hrt und Struktur-Toxizitätsbeziehungen diskutiert.
In Vitro Metabolism of Hepatotoxic Pyrrolizidine Alkaloids
Author: Ina GeburekBiological Reactive Intermediates III
Author: James J. KocsisPublisher: Springer Science & Business Media
ISBN: 1468451340
Category : Science
Languages : en
Pages : 1028
Book Description
This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
Biosynthesis
Author: Finian J. LeeperPublisher: Springer
ISBN: 354048146X
Category : Technology & Engineering
Languages : en
Pages : 255
Book Description
This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). The first volume covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.