Metabolic V Basis of Detoxication PDF Download

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Languages : en
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Author: William B. Jakoby
Publisher: Elsevier
ISBN: 0323137997
Category : Science
Languages : en
Pages : 392

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Book Description
Metabolic Basis of Detoxication: Metabolism of Functional Groups considers the possible fates of the relatively circumscribed number of functional groups that xenobiotics bear. An understanding of the possible reactions, and the chemical and biological factors influencing them, will contribute to the overall predictability of the fate of "real" molecules. This approach attempts to knit together the understanding of metabolic pathways with that of the enzymes that catalyze the specific steps. The book contains 18 chapters and begins with a discussion of the biological oxidation of carbon atoms. This is followed by separate chapters on the metabolism of halogenated aliphatic hydrocarbons, aryl halides, heterocyclic rings, alcohols, aldehydes, and ketones. Subsequent chapters cover oxidative processes such as metabolic dealkylations and biological oxidation at nitrogen centers; the reduction of nitro and azo compounds and tertiary amine N-oxides; the oxidation, alkylation, acylation, and glycosylation of mercaptans; epoxide metabolism; and conjugation of phenols. The book aims to inform and interest the pharmacologist and toxicologist concerning the biochemical aspects and to orient the biochemist to the pharmacological insights required in dealing with the metabolism of xenobiotics.

Author: William B. Jakoby
Publisher: Elsevier
ISBN: 0323138209
Category : Science
Languages : en
Pages : 384

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Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronoside glucuronosyltransferase; the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.

Author: John Caldwell
Publisher:
ISBN: 9780121550608
Category : Science
Languages : en
Pages : 429

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Biological Basis of Detoxication...

Author: WB Jakoby (Ed)
Publisher:
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Category :
Languages : en
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Author: William B. Jakoby
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 392

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Book Description
Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronoside glucuronosyltransferase; the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.

Author: William B. Jakoby
Publisher: Elsevier
ISBN: 0323137989
Category : Science
Languages : en
Pages : 432

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Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.

Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1442

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First multi-year cumulation covers six years: 1965-70.

Author: Georg Hennemann
Publisher: Marcel Dekker
ISBN:
Category : Medical
Languages : en
Pages : 656

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Author: Claudia Voelckel
Publisher: John Wiley & Sons
ISBN: 1118829808
Category : Science
Languages : en
Pages : 470

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This latest volume in Wiley Blackwell’s prestigious Annual Plant Reviews brings together articles that describe the biochemical, genetic, and ecological aspects of plant interactions with insect herbivores.. The biochemistry section of this outstanding volume includes reviews highlighting significant findings in the area of plant signalling cascades, recognition of herbivore-associated molecular patterns, sequestration of plant defensive metabolites and perception of plant semiochemicals by insects. Chapters in the genetics section are focused on genetic mapping of herbivore resistance traits and the analysis of transcriptional responses in both plants and insects. The ecology section includes chapters that describe plant-insect interactions at a higher level, including multitrophic interactions, investigations of the cost-benefit paradigm and the altitudinal niche-breadth hypothesis, and a re-evaluation of co-evolution in the light of recent molecular research. Written by many of the world’s leading researchers in these subjects, and edited by Claudia Voelckel and Georg Jander, this volume is designed for students and researchers with some background in plant molecular biology or ecology, who would like to learn more about recent advances or obtain a more in-depth understanding of this field. This volume will also be of great use and interest to a wide range of plant scientists and entomologists and is an essential purchase for universities and research establishments where biological sciences are studied and taught. To view details of volumes in Annual Plant Reviews, visit: www.wiley.com/go/apr Also available from Wiley: Plant Defense Dale Walters 9781405175890 Herbicides and Plant Physiology, 2nd Edn Andrew Cobb & John Reade 9781405129350