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Author: Gerd Bobe Publisher: ISBN: Category : Languages : en Pages : 320
Book Description
Fatty liver is a major metabolic disorder of dairy cows in early lactation that compromises their health status and reproductive performance and in clinical cases decreases milk production and feed intake. Fatty liver can be treated with 14-d continuous, intravenous infusions of 10 mg/d of glucagon. The objective of the current study was to test whether treatment of fatty liver with 14-d subcutaneous injections of glucagon at 7.5 or 15 mg/d, which is more practical than infusion, would cause similar metabolic responses and improve health status and reproductive performance of dairy cows in early lactation. In the main study, multiparous Holstein cows (n=32) were grouped on the basis of their liver triacylglycerol concentration at d 8 postpartum into "Normal" (n=8; triacylglycerol 1% liver wet wt) and "Susceptible" (n=24; triacylglycerol 1% liver wet wt) cows. "Susceptible" cows were assigned randomly to three groups and beginning at d 8 postpartum received 0 (same for "Normal" cows), 2.5, or 5 mg of glucagon in 60 ml 0.15 M NaCl by subcutaneous injections every 8 h for 14 d. Subcutaneous injections of 15 mg/d of glucagon consistently increased concentrations of plasma glucose and insulin for 4 h, decreased concentrations of liver triacylglycerol in cows older than 3.5 years, and tended to decrease concentrations of plasma NEFA and BHBA. The effects of 15 mg/d of glucagon were not limited to the treatment period, because glucagon decreased the incidence of mastitis and days to first ovarian activity after the injection period. These results document that subcutaneous injections of 15 mg/d or glucagon improve metabolic status throughout the injection period and have the potential to treat fatty liver in older cows. The improved metabolic status in cows treated with 15 mg/d of glucagon in early lactation has long-term beneficial effects by improving health status and reproductive performance during the entire lactation.
Author: Gerd Bobe Publisher: ISBN: Category : Languages : en Pages : 320
Book Description
Fatty liver is a major metabolic disorder of dairy cows in early lactation that compromises their health status and reproductive performance and in clinical cases decreases milk production and feed intake. Fatty liver can be treated with 14-d continuous, intravenous infusions of 10 mg/d of glucagon. The objective of the current study was to test whether treatment of fatty liver with 14-d subcutaneous injections of glucagon at 7.5 or 15 mg/d, which is more practical than infusion, would cause similar metabolic responses and improve health status and reproductive performance of dairy cows in early lactation. In the main study, multiparous Holstein cows (n=32) were grouped on the basis of their liver triacylglycerol concentration at d 8 postpartum into "Normal" (n=8; triacylglycerol 1% liver wet wt) and "Susceptible" (n=24; triacylglycerol 1% liver wet wt) cows. "Susceptible" cows were assigned randomly to three groups and beginning at d 8 postpartum received 0 (same for "Normal" cows), 2.5, or 5 mg of glucagon in 60 ml 0.15 M NaCl by subcutaneous injections every 8 h for 14 d. Subcutaneous injections of 15 mg/d of glucagon consistently increased concentrations of plasma glucose and insulin for 4 h, decreased concentrations of liver triacylglycerol in cows older than 3.5 years, and tended to decrease concentrations of plasma NEFA and BHBA. The effects of 15 mg/d of glucagon were not limited to the treatment period, because glucagon decreased the incidence of mastitis and days to first ovarian activity after the injection period. These results document that subcutaneous injections of 15 mg/d or glucagon improve metabolic status throughout the injection period and have the potential to treat fatty liver in older cows. The improved metabolic status in cows treated with 15 mg/d of glucagon in early lactation has long-term beneficial effects by improving health status and reproductive performance during the entire lactation.
Author: Arnold Ray Hippen Publisher: ISBN: Category : Languages : en Pages : 276
Book Description
To test the hypothesis that glucagon will decrease the severity of fatty liver and prevent ketosis, glucagon was continuously infused via intravenous jugular catheters into dairy cattle in several physiological states. In preliminary dosage response studies, glucagon was infused into eight spayed Holstein heifers, four midlactation Holstein cows, and four early-lactation Brown Swiss cows in cross-over design trials at dosages of 20 mg/d or less for 48 h. Plasma glucose concentrations were increased by glucagon in a dose-dependent manner. Plasma nonesterified fatty acid and ketone body concentrations were not increased by glucagon at 5 mg/d or less, were increased in heifers at 10 mg/d, and increased in cows at 20 mg/d compared with preinfusion concentrations. Glucagon at 10 mg/d was the largest dosage tested in lactating cows that did not elicit a lipolytic or ketogenic response. Glucagon at 10 mg/d or vehicle then was infused for 14 d during a protocol to induce ketosis in 20 early-lactation Holstein cows already having fatty livers.
Author: Pengxiang She Publisher: ISBN: Category : Languages : en Pages : 280
Book Description
Forty early lactation Holstein cows were assigned to four groups of a 2 x 2 factorial design with two nutritional backgrounds (normal and ketosis-susceptible) and two levels of glucagon (O and 10 mg/d from 21 to 35 days postpartum) to study the regulation of glucose metabolism. In normal cows, plasma glucagon and glucose concentrations increased by about 6-fold and 10 mg/dl, respectively, during glucagon infusions, but plasma nonesterified fatty acids, [Beta]-hydroxybutyrate, and urea nitrogen did not change. Liver glycogen decreased at d 2 of glucagon infusions, but it was restored by d 7 and increased to 169% of baseline at 3 d after cessation of infusions. Milk and milk protein yield, but not milk lactose yield, decreased during glucagon infusions.
Author: Pierre Cronjé Publisher: CABI ISBN: 9780851997124 Category : Electronic books Languages : en Pages : 492
Book Description
The International Symposium on Ruminant Physiology (ISRP) is the premier forum for presentation and discussion of advances in knowledge of the physiology of ruminant animals. This book brings together edited versions of the keynote review papers presented at the symposium.
Author: National Research Council Publisher: National Academies ISBN: 0309049970 Category : Technology & Engineering Languages : en Pages : 94
Book Description
In the past decade, animal scientists have learned that administering recombinantly derived somatotropin (growth hormone) to cows improves milk production and that giving beta-adrenergic agonists to meat animals improves productivity and leanness. In order for these metabolic modifiers to yield benefits, however, sound management of the animals' nutrition is necessary. This volume reports on how these substances work in the animals' metabolism, what effects they might have on nutrient requirements of domestic livestock, and what information should be developed further by investigators. The book explores the current understanding of the biology, structure, mechanisms of action, and treatment effects of somatotropin, beta-adrenergic agonists, and anabolic steroids. A companion volume to the Nutrient Requirements of Domestic Animals series, this authoritative volume will be required reading for animal scientists, researchers, veterinarians, livestock farmers, and faculty and students in university animal veterinary science programs.
Author: R. J. Collier Publisher: John Wiley & Sons ISBN: 0813811767 Category : Science Languages : en Pages : 360
Book Description
Environmental stress is one of the most significant factors affecting livestock performance and health, and it is only expected to increase with effects of global warming. Environmental Physiology of Livestock brings together the latest research on environmental physiology, summarizing progress in the field and providing directions for future research. Recent developments in estimating heat stress loads are discussed, as well as key studies in metabolism, reproduction, and genetic expressions. Environmental Physiology of Livestock begins with a survey of current heat indexing tools, highlighting recent discoveries in animal physiology, changes in productivity levels, and new technologies available to better estimate stress response. Using this synopsis as a point of orientation, later chapters hone in on major effects of heat stress, including changing metabolic pathways and nutrient requirements, endocrine regulation of acclimation to environmental stress, and reduced reproductive performance. The text concludes with a thorough discussion of environmental effects on gene expressions, providing important insight for future breeding practices. Environmental Physiology of Livestock is a globally contributed volume and a key resource for animal science researchers, geneticists, and breeders.
Author: National Research Council Publisher: National Academies Press ISBN: 0309037956 Category : Medical Languages : en Pages : 384
Book Description
This lively book examines recent trends in animal product consumption and diet; reviews industry efforts, policies, and programs aimed at improving the nutritional attributes of animal products; and offers suggestions for further research. In addition, the volume reviews dietary and health recommendations from major health organizations and notes specific target levels for nutrients.
Author: Kim D. Rainsford Publisher: CRC Press ISBN: 0203646967 Category : Health & Fitness Languages : en Pages : 801
Book Description
Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. Highlighting the historical evolution of the salicylates and the commercial development of
Author: Gerd Bobe
Author: Gerd Bobe
Author: Arnold Ray Hippen
Author: Matthew Reid Waldrom
Author: Pengxiang She
Author: Mohamed Abdulraheem Osman
Author: Pierre Cronjé
Author: National Research Council
Author: R. J. Collier
Author: National Research Council
Author: Kim D. Rainsford