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Author: Gustav A. Martini Publisher: Springer Science & Business Media ISBN: 3642651313 Category : Medical Languages : en Pages : 349
Book Description
In nearly all parts of the world, the consumption of alcohol is increasing, and the morbidity and mortality of diseases induced by alcohol are rising correspondingly. It has been stated that alcohol is consumed because it pro duces intoxication. This effect is due to its toxicological influence on the central nervous system with the resulting functional disturbances. For many years, the concept that alcoholic liver disease was of nutritional origin and only indirectly related to alcohol consumption and metabolism was accepted. Opinion has changed gradually in recent years and tends now to regard alcohol itself through its combustion, as responsible for many metabolic disorders. Interest in this problem has increased during the past decade, and numerous papers bearing on this subject have appeared. It seems that the oxidation of alcohol in the liver interferes in many ways with the intermediary metabolism of lipids, carbohydrates and proteins, including enzymes and hormones, and exerts damaging influence on the liver, the musculature, the heart, the brain and the kidneys. The "Workshop Symposium" brought together a limited number of the scientists involved in the new development, biochemists, physiologists, pharmacologists, pathologists and clinicians from eight European countries and from the United States and allowed a very lively and informal exchange. The symposium was honored by the presence of Sir Hans Krebs, whose vast experience stimulated the discussion. It is a great pleasure to dedicate this volume to Sir Hans on the occasion of his 70th birthday on August 25th.
Author: Gustav A. Martini Publisher: Springer Science & Business Media ISBN: 3642651313 Category : Medical Languages : en Pages : 349
Book Description
In nearly all parts of the world, the consumption of alcohol is increasing, and the morbidity and mortality of diseases induced by alcohol are rising correspondingly. It has been stated that alcohol is consumed because it pro duces intoxication. This effect is due to its toxicological influence on the central nervous system with the resulting functional disturbances. For many years, the concept that alcoholic liver disease was of nutritional origin and only indirectly related to alcohol consumption and metabolism was accepted. Opinion has changed gradually in recent years and tends now to regard alcohol itself through its combustion, as responsible for many metabolic disorders. Interest in this problem has increased during the past decade, and numerous papers bearing on this subject have appeared. It seems that the oxidation of alcohol in the liver interferes in many ways with the intermediary metabolism of lipids, carbohydrates and proteins, including enzymes and hormones, and exerts damaging influence on the liver, the musculature, the heart, the brain and the kidneys. The "Workshop Symposium" brought together a limited number of the scientists involved in the new development, biochemists, physiologists, pharmacologists, pathologists and clinicians from eight European countries and from the United States and allowed a very lively and informal exchange. The symposium was honored by the presence of Sir Hans Krebs, whose vast experience stimulated the discussion. It is a great pleasure to dedicate this volume to Sir Hans on the occasion of his 70th birthday on August 25th.
Author: Charles S. Lieber Publisher: Springer Science & Business Media ISBN: 9401161534 Category : Medical Languages : en Pages : 309
Book Description
In the first annual report on Alcohol and. Health to Congress (December, 1971), the then HEW Secretary Elliot L. Richardson called alcohol 'the most abused drug in the United States'. The report revealed that nine million Americans are alcohol abusers and that alcoholic individuals represent almost 10 % of the nation's work force. With spreading alcoholism, the incidence of physical damage due to alcohol has greatly increased. A question which is often raised is 'in which way does an alcoholic differ from a non-alcoholic?' Inquiries have focused on psychological make-up, behavioural differences and socioeconomic factors. More recently, however, physical differences have been delineated. Prior to the development of various disease entities, chronic ethanol exposure results in profound biochemical and morphological changes. Consequently an alcoholic does not respond normally to alcohol, or other drugs or even other toxic agents. Some of these persistent biochemical and morphological changes are the consequences of the injurious effects of ethanol, whereas others may represent the possible adaptive responses to the profound changes in intermediary metabolism which are a direct and im mediate consequence of the oxidation of ethanol itself. Differentiation between the effects of ethanol directly linked to its oxidation, and the adaptive and injurious effects of ethanol are not simple, and overlap is common. In general, however, metabolic effects are associated with the presence of relatively low ethanol concentrations, whereas injurious effects occur with high ethanol concentrations and/or after prolonged intake. High ethanol con centrations also produce so-called pharmacological effects.
Author: Maria Klopocka Publisher: Nova Science Publishers ISBN: 9781606921395 Category : Alcoholism Languages : en Pages : 0
Book Description
Alcohol abuse is associated with psycho-somatic health and social problems. It leads to multi-organ, especially cardiovascular system, alimentary tract, liver, pancreas and immunologic system dysfunction. Therefore withdrawal and anti-relapse therapy should be undoubtedly undertaken in every case. Nevertheless our knowledge about alcohol withdrawal consequences is insufficient. The main purpose of the authors' investigation was to determine the metabolic, endocrine, haemostatic and immunologic changes during six-month long abstinence period. They studied the abstinence effect on exercise capacity and autonomic nervous system activity estimated by heart rate variability analysis. Their research concerned also changes in upper digestive tract macroscopic and microscopic appearance and its motility, liver function, pro- anti- oxidative balance parameters level, cytokine TNF- alpha and nitric oxide (NO) metabolites plasma concentration. The authors estimated inter-relationships between studied parameters, what seems to be very important in complete analysis. Within six-months long abstinence period pro-atherogenic metabolic changes expressed by decreased HDL and increased LDL- cholesterol plasma concentration occurred. These unfavourable changes were less expressed in patients treated with naltrexone. In the early abstinence period indirect markers of platelets activation were determined. The highest level of fibrinogen, thrombomodulin, antithrombin, markers of trombinogenesis activation in vivo (thrombin- antithrombin, TAT complexes), tissue type plasminogen activator antigen (t-PA:Ag), antigen of plasminogen activator inhibitor type 1 (PAI-1:Ag), markers of fibrinolysis activation in vivo, such as D-dimers, plasmin- alpha2- antiplasmin (PAP) complexes was also observed. Mentioned changes were expressed in patients with determinable TNF-alpha plasma level. Abstinence improved effort capacity, positively changed autonomic nervous system activity via vagal nerve influence on heart rate variability. The last finding was also affected by TNF-alpha level. No significant changes appeared in alimentary tract function, estimated by esophageal and gastric pH-metry, esophageal manometry and abdominal ultrasonography, whereas some changes were observed in endoscopic examinations and influence of patients mental status on investigated parameters became noticeable. Favourable effect on liver function tests was affected by pituitary-thyroid and pituitary-gonadal axes hormones, cytokine TNF-alpha, nutrition status, Helicobacter pylori infection and gastric acidity. Some of studied parameters, such as mean platelets volume and nitric oxide metabolites plasma level may be used as new, valuable markers of alcohol abuse. Alcohol withdrawal and early abstinence is a dynamic period with potentially harmful health consequences, especially in cardiovascular system. This suggests the need of multicentre studies to estimate clinical importance of found changes and cost- benefits analysis of selected interventions.
Author: Henri Begleiter Publisher: Oxford University Press, USA ISBN: 9780195100945 Category : Alcohol Languages : en Pages : 544
Book Description
This is a comprehensive review of the pharmacological effects of alcohol and the mechanisms underlying the pathogenesis of alcoholism. The book draws on general pharmacology, neuropharmacology, and alcohol studies to explore its theme. The second volume in the ALCOHOL AND ALCOHOLISM series, it focuses on the pharmacologic mechanisms underlying the development of alcoholism. The first section on basic pharmacology is concerned with those aspects that are common to all of alcohol's effects. These include pharmacokinetics, general metabolism, and cross-tolerance. The second section on neuropharmacology describes the effects of alcohol on various brain functions, including circulation and metabolism. The third section provides an in-depth review of the neurobiology of physical dependence, withdrawal, and physiological tolerance. The book as a whole gives a comprehensive and authoritative picture of the complex pharmacologic actions of alcohol, particularly on the nervous system. For clinicians and researchers in the field of alcohol and alcoholism, it will serve as a fundamental reference.
Author: Amitava Dasgupta Publisher: Academic Press ISBN: 012809334X Category : Medical Languages : en Pages : 238
Book Description
Alcohol, Drugs, Genes and the Clinical Laboratory provides an overview and quick reference to genetic relationships and clinical laboratory information related to the serious public health issue of alcohol and drug abuse. Written in a clear and concise manner, this book discusses the necessary information for health and safety professionals working in public health to learn about complex issues quickly to better help their patients, employees, and others affected by alcohol and drug abuse. Alcohol, Drugs, Genes and the Clinical Laboratory covers the important aspects of drugs and alcohol abuse including genetic aspects along with laboratory methods for analysis of alcohol and abused drugs with emphasis on false positive test results. The book is helpful to healthcare professionals, such as pathologists who oversee alcohol and drug testing, emergency room physicians, family practice physicians who are first healthcare professionals who identify patients susceptible to drug and alcohol abuse, and psychiatrists involved with drug and alcohol rehabilitation programs. It will also be useful to safety professionals who have to assess individuals for workplace responsibilities, ranging from police and recruitment to occupational safety and occupational medicine and public health officials. - Features accessible language for healthcare and safety professionals who are not experts in laboratory procedures - Provides examples from clinical and everyday situations - Explains how to interpret laboratory results and the latest genetic factors regarding drug and alcohol abuse
Author: Edith V. Sullivan Publisher: Elsevier ISBN: 0444626220 Category : Science Languages : en Pages : 703
Book Description
Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism. - The first focused reference specifically on alcohol and the brain - Details our current understanding of how alcohol impacts the central nervous system - Covers clinical and social impact of alcohol abuse disorders and the biomedical consequences of alcohol abuse - Includes section on neuroimaging of neurochemical markers and brain function
Author: Henri Begleiter Publisher: Alcohol and Alcoholism ISBN: 9780195088779 Category : Alcoholism Languages : en Pages : 420
Book Description
This volume provides an in-depth look at the genetic influences that contribute to the development of alcoholism. Part I: Epidemiologic Studies contains five chapters that examine the various approaches employed in the study of the genetics of alcoholism. It provides a historical perspectiveand details all the essentials of this subject. Part II: Selective Breeding Studies highlights the results of research involving the selective breeding of rodents. This type of research has produced homogenous strains exhibiting specific behavioral responses considered significant in thedevelopment and maintenance of alcohol dependence. The studies presented in Part III: Phenotypic Studies investigate and analyze phenotypic markers that serve as correlates to the genotypic determinants of alcoholism. Through its broad scope, this volume provides for the first time a panoramic viewof the knowledge available on the hereditary influences of alcoholism.
Author: Gustav A. Martini
Author: Gustav A. Martini
Author: G. A. Martini
Author: 
Author: Erkki Heikkonen
Author: Charles S. Lieber
Author: Maria Klopocka
Author: Henri Begleiter
Author: Amitava Dasgupta
Author: Edith V. Sullivan
Author: Henri Begleiter