Author: Raúl Aguilar-Roblero Publisher: Springer ISBN: 3319089455 Category : Medical Languages : en Pages : 396
Book Description
Well known experts in the field of Chronobiology from around the world, provide an integrative view of the state of the art of circadian biology. At present, genetic and epigenetic interaction of regulatory pathways among circadian oscillators, metabolic networks, cellular differentiation and neuronal communication are subject of intense scrutiny. The book is organized in three sections: The first includes selected examples of the circadian systems of crustaceans, insects, fish, birds and mammals. The second is a detailed view of the physiological mechanisms underlying the circadian clocks in mammals. Finally, in the third section some examples of the relevance of circadian biology and circadian misalignment to health and disease are provided including nutrition and metabolism, obesity, cancer, cardiovascular and pulmonary diseases, Huntington and affective diseases. This section concludes with a brief review on gene therapy and its potential use as a therapeutic tool to correct “clock genes” pathologies. This book is aimed at all those interested in contemporary aspects of physiology, biochemistry and molecular biology applied to the study and characterization of timing systems.. It could be used as an initial approach to this field, but it also provides updated information for those already familiar with the fascinating field of Chronobiology.
Author: Derek J. Chadwick Publisher: John Wiley & Sons ISBN: 0470514604 Category : Science Languages : en Pages : 348
Book Description
Prestigious contributors describe the genetic, molecular, anatomical and neurochemical mechanisms and pathways that operate to regulate and control circadian rhythmicity and functioning in organisms ranging from unicellular algae to human beings. Also considers the implications of the basic and clinical research for humans.
Author: Urs Albrecht Publisher: Springer Science & Business Media ISBN: 1441912622 Category : Science Languages : en Pages : 306
Book Description
With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.
Author: Leon Kreitzman Publisher: Profile Books ISBN: 1847653723 Category : Science Languages : en Pages : 288
Book Description
Popular science at its most exciting: the breaking new world of chronobiology - understanding the rhythm of life in humans and all plants and animals. The entire natural world is full of rhythms. The early bird catches the worm -and migrates to an internal calendar. Dormice hibernate away the winter. Plants open and close their flowers at the same hour each day. Bees search out nectar-rich flowers day after day. There are cicadas that can breed for only two weeks every 17 years. And in humans: why are people who work anti-social shifts more illness prone and die younger? What is jet-lag and can anything help? Why do teenagers refuse to get up in the morning, and are the rest of us really 'larks' or 'owls'? Why are most people born (and die) between 3am-5am? And should patients be given medicines (and operations) at set times of day, because the body reacts so differently in the morning, evening and at night? The answers lie in our biological clocks the mechanisms which give order to all living things. They impose a structure that enables us to change our behaviour in relation to the time of day, month or year. They are reset at sunrise and sunset each day to link astronomical time with an organism's internal time.
Author: Publisher: Academic Press ISBN: 0123786118 Category : Science Languages : en Pages : 2626
Book Description
In a world of 24-hour media saturation, sleep has become an increasingly fraught enterprise. The award-winning four-volume Encyclopedia of Sleep, Four Volume Set is the largest reference, either online or in print, on the subject of sleep. Written to be useful for the novice and the established researcher and clinician, Topic areas will include sleep across the life cycle and in other species, sleep and women, sleep and the elderly, pediatric sleep, sleep deprivation and loss, sleep mechanisms, sleep physiology and pathophysiology, sleep disorders, neurobiology, chronobiology, pharmacology, and impact of other disorders on sleep. Recognizing the many fields that are connected to sleep science, the editorial team has been carefully chosen to do justice to this highly interdisciplinary field of study. The steady growth of researchers and clinicians in the sleep field attests to the continued interest in the scientific study of sleep and the management of patients with sleep disorders, and anyone involved in this exciting field should find this work to be an invaluable reference. 2013 PROSE Award winner for Multivolume Reference in Science from the Association of American Publishers Thoroughly interdisciplinary: looks at sleep throughout the life cycle, with exceptional coverage of basic sleep concepts, the physiology of sleep as well as sleep disorders of all descriptions Excellent coverage of sleep and special populations, covering the lifespan, as well as gender and ethnic differences, among others Chapters focusing on sleep disorders are grouped under the broad categories classified in the ICSD-2 for clear organization so that the reader can effectively access the steps involved in diagnosing and treating these disorders Online version is linked both within the encyclopedia (to related content) and to external sources (such as primary journal content) so that users have easy access to more detailed information if needed
Author: Mohamed A. El-Esawi Publisher: BoD – Books on Demand ISBN: 1789233380 Category : Medical Languages : en Pages : 168
Book Description
Circadian clocks are endogenous and temperature-compensating timekeepers that provide temporal organization of biological processes in living organisms. Circadian rhythms allow living organisms to adapt to the daily light cycles associated with Earth's rotation and to anticipate and prepare for precise and regular environmental changes. This book discusses the fundamental advances of how the circadian clock regulates critical biological functions as well as the cellular and molecular mechanisms controlling circadian rhythm in living organisms. It also provides new insights into and sheds new light on the current research trends and future research directions related to circadian rhythm. This book provokes interest in many readers, researchers and scientists, who can find this information useful for the advancement of their research works towards a better understanding of circadian rhythm regulatory mechanisms.
Author: Etienne Challet Publisher: Frontiers Media SA ISBN: 2889452824 Category : Electronic book Languages : en Pages : 190
Book Description
One of the major breakthroughs of the last decade in the understanding of energy homeostasis is the identification of a reciprocal control between circadian rhythmicity and cellular metabolism. Circadian rhythmicity is a fundamental endogenous process of almost every organism living on Earth. For instance, the alternation of hunger and satiety is not continuous over 24 h, but is instead structured in time along the light/dark cycle. In mammals, the temporal organization of metabolism, physiology and behavior around 24 h is controlled by a network of multiple cellular clocks, synchronized via neuronal and hormonal signals by a master clock located in the suprachiasmatic nuclei of the hypothalamus. This central circadian conductor in the brain is mainly reset by ambient light perceived by the retina, while secondary circadian clocks in other brain areas and peripheral organs can be reset by meal timing. Chronic disruption of circadian rhythms, as seen in human shift-workers (up to 20% of the active population), has been associated with the development of a number of adverse mental and metabolic conditions. Understanding of the functional links between circadian desynchronization and overall health in animal models and humans, however, is still scarce. Interactions between circadian clocks and metabolism can occur at different levels: the molecular clockwork, internal synchronization via neuro-hormonal signals, or external synchronization via photic or feeding cues. This Research Topic comprises a number of reviews as well as research and methods articles that feature recent advancements in the mechanisms linking circadian clocks with energy metabolism, and the pathophysiological implications of these interactions for metabolic health.
Author: Eberhard Gwinner Publisher: Springer Science & Business Media ISBN: 3642828701 Category : Science Languages : en Pages : 161
Book Description
In addition to the more or less static properties of the environ ment, plants and animals must cope with its temporal variations. Among the most conspicuous temporal changes to which organisms are exposed are periodic phenomena generated by the rotation of the earth about its axis, its revolution around the sun, and the more complex movements of the moon in relation to both sun and earth. The first two of these astronomical cycles are basic to the familiar daily and annual rhythms, respectively, in the environment. The third generates somewhat more complex cycles, such as those in moonlight and variations in tides. These environmental cycles have provided challenges and opportunities for organisms to adjust their physiology and behavior to them. Indeed, the predictability inherent to these periodic processes has enabled organisms to evolve innate endogenous rhythmic programs that match the environmental cycles and allow, in a variety of different ways, adjustment of biological activities to the cycles of environmental changes. The endogenous nature of rhythmicity was first clearly recognized in the 1930's in daily periodicities, the most widely distributed and best investigated class of biological rhythms of this type. In the 1950's, demonstrations of endogenous tidal and lunar rhythms, which occur in some littoral and marine organisms, ensued. Another decade passed before endogenous annual periodicities were first demonstrated unambiguously.
Author: Publisher: Academic Press ISBN: 0123876982 Category : Science Languages : en Pages : 269
Book Description
This latest volume in Advances in Genetics covers the genetics of Circadian rhythms. With an international group of authors this volume is the latest offering in this widely praised series.
Author: Raúl Aguilar-Roblero
Author: Derek J. Chadwick
Author: Charles A. Czeisler
Author: Urs Albrecht
Author: Leon Kreitzman
Author: 
Author: Mohamed A. El-Esawi
Author: Etienne Challet
Author: Eberhard Gwinner
Author: