Mathematical Models in Epidemiology PDF Download

Author: Fred Brauer
Publisher: Springer Nature
ISBN: 1493998285
Category : Mathematics
Languages : en
Pages : 628

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Book Description
The book is a comprehensive, self-contained introduction to the mathematical modeling and analysis of disease transmission models. It includes (i) an introduction to the main concepts of compartmental models including models with heterogeneous mixing of individuals and models for vector-transmitted diseases, (ii) a detailed analysis of models for important specific diseases, including tuberculosis, HIV/AIDS, influenza, Ebola virus disease, malaria, dengue fever and the Zika virus, (iii) an introduction to more advanced mathematical topics, including age structure, spatial structure, and mobility, and (iv) some challenges and opportunities for the future. There are exercises of varying degrees of difficulty, and projects leading to new research directions. For the benefit of public health professionals whose contact with mathematics may not be recent, there is an appendix covering the necessary mathematical background. There are indications which sections require a strong mathematical background so that the book can be useful for both mathematical modelers and public health professionals.

Author: Fred Brauer
Publisher: Springer Science & Business Media
ISBN: 1475735162
Category : Science
Languages : en
Pages : 432

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Book Description
The goal of this book is to search for a balance between simple and analyzable models and unsolvable models which are capable of addressing important questions on population biology. Part I focusses on single species simple models including those which have been used to predict the growth of human and animal population in the past. Single population models are, in some sense, the building blocks of more realistic models -- the subject of Part II. Their role is fundamental to the study of ecological and demographic processes including the role of population structure and spatial heterogeneity -- the subject of Part III. This book, which will include both examples and exercises, is of use to practitioners, graduate students, and scientists working in the field.

Author: Maia Martcheva
Publisher: Springer
ISBN: 1489976124
Category : Mathematics
Languages : en
Pages : 462

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Book Description
The book is a comprehensive, self-contained introduction to the mathematical modeling and analysis of infectious diseases. It includes model building, fitting to data, local and global analysis techniques. Various types of deterministic dynamical models are considered: ordinary differential equation models, delay-differential equation models, difference equation models, age-structured PDE models and diffusion models. It includes various techniques for the computation of the basic reproduction number as well as approaches to the epidemiological interpretation of the reproduction number. MATLAB code is included to facilitate the data fitting and the simulation with age-structured models.

Author: O. Diekmann
Publisher: John Wiley & Sons
ISBN: 9780471492412
Category : Mathematics
Languages : en
Pages : 324

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Book Description
Mathematical Epidemiology of Infectious Diseases Model Building, Analysis and Interpretation O. Diekmann University of Utrecht, The Netherlands J. A. P. Heesterbeek Centre for Biometry Wageningen, The Netherlands The mathematical modelling of epidemics in populations is a vast and important area of study. It is about translating biological assumptions into mathematics, about mathematical analysis aided by interpretation and about obtaining insight into epidemic phenomena when translating mathematical results back into population biology. Model assumptions are formulated in terms of, usually stochastic, behaviour of individuals and then the resulting phenomena, at the population level, are unravelled. Conceptual clarity is attained, assumptions are stated clearly, hidden working hypotheses are attained and mechanistic links between different observables are exposed. Features: * Model construction, analysis and interpretation receive detailed attention * Uniquely covers both deterministic and stochastic viewpoints * Examples of applications given throughout * Extensive coverage of the latest research into the mathematical modelling of epidemics of infectious diseases * Provides a solid foundation of modelling skills The reader will learn to translate, model, analyse and interpret, with the help of the numerous exercises. In literally working through this text, the reader acquires modelling skills that are also valuable outside of epidemiology, certainly within population dynamics, but even beyond that. In addition, the reader receives training in mathematical argumentation. The text is aimed at applied mathematicians with an interest in population biology and epidemiology, at theoretical biologists and epidemiologists. Previous exposure to epidemic concepts is not required, as all background information is given. The book is primarily aimed at self-study and ideally suited for small discussion groups, or for use as a course text.

Author: Fred Brauer
Publisher: Springer Science & Business Media
ISBN: 3540789103
Category : Medical
Languages : en
Pages : 415

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Book Description
Based on lecture notes of two summer schools with a mixed audience from mathematical sciences, epidemiology and public health, this volume offers a comprehensive introduction to basic ideas and techniques in modeling infectious diseases, for the comparison of strategies to plan for an anticipated epidemic or pandemic, and to deal with a disease outbreak in real time. It covers detailed case studies for diseases including pandemic influenza, West Nile virus, and childhood diseases. Models for other diseases including Severe Acute Respiratory Syndrome, fox rabies, and sexually transmitted infections are included as applications. Its chapters are coherent and complementary independent units. In order to accustom students to look at the current literature and to experience different perspectives, no attempt has been made to achieve united writing style or unified notation. Notes on some mathematical background (calculus, matrix algebra, differential equations, and probability) have been prepared and may be downloaded at the web site of the Centre for Disease Modeling (www.cdm.yorku.ca).

Author: Jyoti Mishra
Publisher: CRC Press
ISBN: 1000226948
Category : Mathematics
Languages : en
Pages : 441

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Book Description
This book describes the uses of different mathematical modeling and soft computing techniques used in epidemiology for experiential research in projects such as how infectious diseases progress to show the likely outcome of an epidemic, and to contribute to public health interventions. This book covers mathematical modeling and soft computing techniques used to study the spread of diseases, predict the future course of an outbreak, and evaluate epidemic control strategies. This book explores the applications covering numerical and analytical solutions, presents basic and advanced concepts for beginners and industry professionals, and incorporates the latest methodologies and challenges using mathematical modeling and soft computing techniques in epidemiology. Primary users of this book include researchers, academicians, postgraduate students, and specialists.

Author: James C. Frauenthal
Publisher: Springer Science & Business Media
ISBN: 3642677959
Category : Mathematics
Languages : en
Pages : 128

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Book Description
The text of this book is derived from courses taught by the author in the Department of Applied Mathematics and Statistics at the State University of New York at Stony Brook. The audience for these courses was composed almost entirely of fourth year undergraduate students majoring in the mathematical sciences. The students had ordinarily completed four semesters of calculus and one of probability. Few had any prior experience with differential equations, stochastic processes, or epidemiology. It also seems prudent to mention that the author's background is in engineering and applied mathematics and not in epidemiology; it is hoped that this is not painfully obvious. The topics covered in this book have in some cases been modified from the way they were originally presented. However, care has been taken to include a suitable amount of material for a one semester course; the temptation to add gratuitous subject matter has been resisted. Similarly, when a choice between clarity and rigor was available, the more easily understood exposition was selected. By looking only at the table of contents, the casual reader could be easily misled into thinking that the main concern of this book is with epidemiology. This is not the case. The purpose of this book is to illustrate the process of formulating and solving mathematical models.

Author: Odo Diekmann
Publisher: Princeton University Press
ISBN: 1400845629
Category : Science
Languages : en
Pages : 517

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Book Description
Mathematical modeling is critical to our understanding of how infectious diseases spread at the individual and population levels. This book gives readers the necessary skills to correctly formulate and analyze mathematical models in infectious disease epidemiology, and is the first treatment of the subject to integrate deterministic and stochastic models and methods. Mathematical Tools for Understanding Infectious Disease Dynamics fully explains how to translate biological assumptions into mathematics to construct useful and consistent models, and how to use the biological interpretation and mathematical reasoning to analyze these models. It shows how to relate models to data through statistical inference, and how to gain important insights into infectious disease dynamics by translating mathematical results back to biology. This comprehensive and accessible book also features numerous detailed exercises throughout; full elaborations to all exercises are provided. Covers the latest research in mathematical modeling of infectious disease epidemiology Integrates deterministic and stochastic approaches Teaches skills in model construction, analysis, inference, and interpretation Features numerous exercises and their detailed elaborations Motivated by real-world applications throughout

Author: Alexander Krämer
Publisher: Springer Science & Business Media
ISBN: 0387938354
Category : Medical
Languages : en
Pages : 441

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Book Description
Hardly a day goes by without news headlines concerning infectious disease threats. Currently the spectre of a pandemic of influenza A|H1N1 is raising its head, and heated debates are taking place about the pro’s and con’s of vaccinating young girls against human papilloma virus. For an evidence-based and responsible communication of infectious disease topics to avoid misunderstandings and overreaction of the public, we need solid scientific knowledge and an understanding of all aspects of infectious diseases and their control. The aim of our book is to present the reader with the general picture and the main ideas of the subject. The book introduces the reader to methodological aspects of epidemiology that are specific for infectious diseases and provides insight into the epidemiology of some classes of infectious diseases characterized by their main modes of transmission. This choice of topics bridges the gap between scientific research on the clinical, biological, mathematical, social and economic aspects of infectious diseases and their applications in public health. The book will help the reader to understand the impact of infectious diseases on modern society and the instruments that policy makers have at their disposal to deal with these challenges. It is written for students of the health sciences, both of curative medicine and public health, and for experts that are active in these and related domains, and it may be of interest for the educated layman since the technical level is kept relatively low.

Author: Fred Brauer
Publisher: SIAM
ISBN: 9781611972429
Category : Mathematics
Languages : en
Pages : 288

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Book Description
This graduate-level textbook appeals to readers interested in the mathematical theory of disease transmission models. It is self-contained and accessible to readers who are comfortable with calculus, elementary differential equations, and linear algebra. The book provides insight into modeling cross-immunity between different disease strains (such as influenza) and the synergistic interactions between multiple diseases (e.g., HIV and tuberculosis); diseases transmitted by viral agents, bacteria, and vectors (e.g., mosquitos transmitting malaria to humans); and both epidemic and endemic disease occurrences.