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Author: Jennie C. Hunter-Cevera Publisher: Elsevier ISBN: 0080535755 Category : Science Languages : en Pages : 279
Book Description
To retain their usefulness, cultures that manufacture economically valuable products must be uncontaminated, viable, and genetically stable. Maintaining Cultures for Biotechnology and Industry gives practical advice necessary to preserve and maintain cells and microorganisms important to the biotechnology and pharmaceutical industries in ways that ensure they will continue to be able to synthesize those valuable metabolites. This book covers not just those strains currently being used but also those yet to be discovered and engineered.This text is essential for anyone working with cultures who wants to avoid the frustration of losing strains and needs to be able to devise and evaluate new strategies for preservation. Written by hands-on experts in their respective fields Contains helpful tables and protocols for preserving or maintaining cells, cultures and viruses Discusses means to preserve cells by freezing, lyophilization, drying, cyoprotection, spore storage, continuous propagation and subculturing when absolutely necessary, and others Gives information needed to test cultures for stable retention of important characteristics Gives principles needed to devise and evaluate preservation strategies for newly identified and newly engineered cells and organisms Lists culture sources for each class of organism Includes information for characterizing and monitoring recombinant organisms, especially important because of their propensity for genetic stability Discusses the history of the continually evolving field of culture preservation Examines the importance of genetically stable cultures as it relates to maintaining patent positions
Author: Jennie C. Hunter-Cevera Publisher: Elsevier ISBN: 0080535755 Category : Science Languages : en Pages : 279
Book Description
To retain their usefulness, cultures that manufacture economically valuable products must be uncontaminated, viable, and genetically stable. Maintaining Cultures for Biotechnology and Industry gives practical advice necessary to preserve and maintain cells and microorganisms important to the biotechnology and pharmaceutical industries in ways that ensure they will continue to be able to synthesize those valuable metabolites. This book covers not just those strains currently being used but also those yet to be discovered and engineered.This text is essential for anyone working with cultures who wants to avoid the frustration of losing strains and needs to be able to devise and evaluate new strategies for preservation. Written by hands-on experts in their respective fields Contains helpful tables and protocols for preserving or maintaining cells, cultures and viruses Discusses means to preserve cells by freezing, lyophilization, drying, cyoprotection, spore storage, continuous propagation and subculturing when absolutely necessary, and others Gives information needed to test cultures for stable retention of important characteristics Gives principles needed to devise and evaluate preservation strategies for newly identified and newly engineered cells and organisms Lists culture sources for each class of organism Includes information for characterizing and monitoring recombinant organisms, especially important because of their propensity for genetic stability Discusses the history of the continually evolving field of culture preservation Examines the importance of genetically stable cultures as it relates to maintaining patent positions
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309055822 Category : Science Languages : en Pages : 105
Book Description
The United States is entering an era when, more than ever, the sharing of resources and information might be critical to scientific progress. Every dollar saved by avoiding duplication of efforts and by producing economies of scale will become increasingly important as federal funding enters an era of fiscal restraint. This book focuses on six diverse case studies that share materials or equipment with the scientific community at large: the American Type Culture Collection, the multinational coordinated Arabidopsis thaliana Genome Research Project, the Jackson Laboratory, the Washington Regional Primate Research Center, the Macromolecular Crystallography Resource at the Cornell High-Energy Synchrotron Source, and the Human Genome Center at Lawrence Livermore National Laboratory. The book also identifies common strengths and problems faced in the six cases, and presents a series of recommendations aimed at facilitating resource sharing in biomedical research.
Author: Syed Imtiaz Haider Publisher: CRC Press ISBN: 1420084496 Category : Medical Languages : en Pages : 868
Book Description
All manufacturing companies face the daunting task of designing an employee training matrix that meets the gamut of national and international regulatory standards. Answering the call for a one-stop training resource that focuses exclusively on this multi-faceted, high-tech industry, Biotechnology: A Comprehensive Training Guide for the Biotechnolo
Author: Sushil K. Sharma Publisher: Springer ISBN: 3319969714 Category : Science Languages : en Pages : 451
Book Description
This book covers broad areas in the conservation of microorganisms. It addresses the short, medium and long-term preservation of agriculturally important microorganisms, as well as culture collections and their roles. The respective chapters address topics such as conventional approaches to bacterial, fungal and algal preservation, as well as methods and strategies for preserving recalcitrant microorganisms. Readers will also find the latest insights into the preservation of vesicular-arbuscular (VA) fungi and ecology, diversity and conservation of endophytes, and entamopathogenic fungi. Microbes of animal and dairy origin, their preservation and biosafety issues are also explored. Microorganisms are the silent and unseen majority of life on Earth, and are characterized by a high degree of genetic and metabolic diversity. It is well documented that no branch of science or society is unaffected by microbial interventions. Researchers have documented microorganisms from such extreme and unique environments as deserts and hydrothermal vents, and with specific traits that are currently being exploited in agriculture, industry, medicine and biotechnological applications. Such great potential can only be found in microorganisms. The aim of this book – the first entirely devoted to the conservation of microorganisms, and to regulatory mechanisms for access and benefits sharing as per Biological Diversity (BD) Act 2002 – is to promote awareness of our world’s microbial wealth, and to introduce readers to strategies and methodologies for the conservation of microorganisms, which could ultimately save human life on Earth.
Author: National Research Council Publisher: National Academies Press ISBN: 0309046858 Category : Medical Languages : en Pages : 208
Book Description
In developing countries, traditional fermentation serves many purposes. It can improve the taste of an otherwise bland food, enhance the digestibility of a food that is difficult to assimilate, preserve food from degradation by noxious organisms, and increase nutritional value through the synthesis of essential amino acids and vitamins. Although "fermented food" has a vaguely distasteful ring, bread, wine, cheese, and yogurt are all familiar fermented foods. Less familiar are gari, ogi, idli, ugba, and other relatively unstudied but important foods in some African and Asian countries. This book reports on current research to improve the safety and nutrition of these foods through an elucidation of the microorganisms and mechanisms involved in their production. Also included are recommendations for needed research.
Author: Pete H. Calcott Publisher: CRC Press ISBN: 1000694577 Category : Science Languages : en Pages : 200
Book Description
First Published in 1981, this book offers a full insight into the development of cell cultures. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of microbiology and other practitioners in their respective fields.
Author: Hans-Peter Meyer Publisher: John Wiley & Sons ISBN: 3527683356 Category : Science Languages : en Pages : 642
Book Description
The submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry itself. Depending on the maturity of the technology, the chapters address in turn the expression system, basic process design, key factors affecting process economics, plant and bioreactor design, and regulatory aspects.
Author: Gunasekaran Thirumurugan Publisher: Gunasekaran Thirumurugan ISBN: Category : Science Languages : en Pages : 269
Book Description
This book is related to bio-process/fermentation technology; it starts with introduction which covers types of fermentation process, isolation, screening and maintenance of microbial cultures and strain improvements. The second chapter deals with the design, construction aspects of bioreactor and third chapter discuss the different modes of bioreactor operation. The chapter 4 deals with on-line measurement and control of bio-process and types of reactor discussed in the fifth chapter. Fermentation kinetics and downstream process is discussed in the subsequent chapters. The last chapter of this section deals with the Bio processing of the industrially important microbial metabolites.
Author: Scott Dessain Publisher: Academic Press ISBN: 0128092092 Category : Medical Languages : en Pages : 277
Book Description
Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This "Valley of Death" squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of "conventional wisdom" that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. Explains why translation of biotech discovery into medicine succeeds so infrequently that it’s been dubbed the Valley of Death Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better
Author: Jennie C. Hunter-Cevera
Author: Jennie C. Hunter-Cevera
Author: Institute of Medicine
Author: D. Smith
Author: Syed Imtiaz Haider
Author: Sushil K. Sharma
Author: National Research Council
Author: Pete H. Calcott
Author: Hans-Peter Meyer
Author: Gunasekaran Thirumurugan
Author: Scott Dessain