Magnetic Iron Oxide Nanoparticles as Potential Contrast Agents for Magnetic Resonance Imaging PDF Download

Author: Christoph Schweiger
Publisher:
ISBN:
Category :
Languages : en
Pages : 216

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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description
This thesis presents the development of novel formulations on the basis of magnetic iron oxide nanoparticles. Optimization of the synthesis route resulted in the development of particles meeting general requirements for eventual applications. Furthermore, the selection of appropriate stabilizing agents imparted the nanoparticles with beneficial features, making an in vivo application possible. In doing so, the formulations seem to be especially promising for the application as contrast agents in magnetic resonance imaging. Chapter 1 gives a brief insight into current research in the field of magnetic nanoparticles. While the originally promoted idea of dragging nanoparticles to the site of action by a massive external field is becoming less important, the use of magnetic carriers as single and multifunctional imaging agents is gaining in importance. Chapter 2 describes the synthesis of magnetic iron oxide nanoparticles with optimal properties for MRI contrast enhancement and the comparative assessment of polymeric macromolecules as stabilizers for such nanoparticles. It was revealed that particles covered by poly(ethylene imine)-g-poly(ethylene glycol) performed better than their poly(ethylene imine) counterparts, in terms of stability and cytotoxicity. The systems containing the former polymer showed pronounced colloidal stability even in protein-rich cell media. In addition, cytotoxicity was reduced by more than an order of magnitude. In this respect, the assumptions made in the run-up to the studies have found confirmation. Indeed, the introduction of hydrophilic poly(ethylene glycol) moieties to the polymer backbone positively manipulated the above properties. In addition, the physicochemical properties of the generated iron oxide nanoparticles were found to be excellent, despite the simplicity of the synthesis procedure. The iron oxide cores displayed high crystallinity, high saturation magnetization and superparamagnetic features. The polymer-coated nanopartic.

Author: Nicholas J. Darton
Publisher: Cambridge University Press
ISBN: 1107031095
Category : Medical
Languages : en
Pages : 317

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Drawing together topics from a wide range of disciplines, and featuring up-to-date examples of clinical usage and research applications, this text provides a comprehensive insight into the fundamentals of magnetic biosensors and the applications of magnetic nanoparticles in medicine.

Author: Alain R. Puente-Santiago
Publisher: Springer Nature
ISBN: 303055502X
Category : Science
Languages : en
Pages : 255

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Book Description
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Author: Costica Caizer
Publisher: John Wiley & Sons
ISBN: 1119754747
Category : Science
Languages : en
Pages : 512

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Book Description
Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

Author: Michele Huelar Pablico
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 564

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The most common MRI contrast agents that are in clinical use today are gadolinium chelates and superparamagnetic iron oxide nanoparticles, both of which have their own advantages in terms of contrast enhancement properties. In the past few years, however, there has been interest in utilizing metal-containing clusters for MRI contrast enhancement as these materials bridge the gap between the constrained structure and magnetic properties of the gadolinium chelates with the superparamagnetic behavior of the iron oxide nanoparticles. Recently, metallic clusters containing Mn and Fe metal centers have received increased attention mainly because of their potential for high spin states and benign nature.

Author: Sophie Laurent
Publisher: Springer
ISBN: 9811025290
Category : Technology & Engineering
Languages : en
Pages : 128

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This book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc.

Author: Costica Caizer
Publisher: John Wiley & Sons
ISBN: 1119754674
Category : Science
Languages : en
Pages : 516

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Book Description
Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, ­biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer ­therapeutics—featuring discussion of current problems, ­proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

Author: Francesca Garello
Publisher: MDPI
ISBN: 3036502343
Category : Science
Languages : en
Pages : 206

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Book Description
In recent years, micro- and nanosystems with magnetic properties have been extensively investigated in many fields, ranging from physics to medicine. The research in these areas has lately shown that if the magnetic compounds are opportunely functionalized and modified with moieties and specific functional groups, a plethora of challenging multidisciplinary applications is available, including the development of magnetically controlled particles, stimuli-responsive materials, magnetically guided chemical/drug-delivery systems, sensors, spintronics, separation and purification of contaminated groundwater and soils, ferrofluids and magnetorheological fluids, contrast agents for MRI, and internal sources of heat for the thermoablation of cancer. Magnetic compounds have been found to be highly selective and effective in all these application fields, from the molecular level to the microscale. This book aims at underlining the latest advances in the field of magnetic compounds, nanosystems, and materials, covering a large variety of topics related to novel synthesis and functionalization methods and the properties, applications, and use of magnetic systems in chemistry, materials science, diagnostics, and medical therapy.

Author: Reem Alalwan
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
With cancer being the second leading cause of death in the world, early detection of the human disease is a significant field of research that includes the investigation and development of clinical imaging technologies. One of the widely used imaging modalities is magnetic resonance imaging (MRI). The significance of MRI lies in the potential to revolutionize diagnostic medicine through the functionality of early detection of diseases in their initial precipitation stages, thus offering higher probability of better patient outcomes around the world. Conventional MRI scans have low sensitivity with darker images easily confused with voids in certain organs and other soft tissue. The emergence of MRI contrast agents was a game changer. Contrast-enhanced MRI scans modify the magnitude of the signal in the body region where the agent is incorporated, resulting in an increased contrast between normal and abnormal tissues and greater differentiation among normal and diseased tissue for diagnostic purposes. Given the several types of contrasts currently available, the goal of this work is to create an iron-based T1 contrast agent that targets specific cells, delivers an optimized bright signal, and easily clears through the renal system, avoiding any possible depositions in the human body and any fatal conditions such as nephrogenic systemic fibrosis (NSF) which are associated with the administration of the conventional untargeted Gd(III)-based contrast agents. In this study, a hydrothermal synthetic protocol is developed to create 4 nm targeted [gamma]-Fe2O3 nanoparticles with T1 contrast as a potential formulation for contrast-enhanced clinical imaging through MRI. The contrast of the new material is examined in simulated physiological conditions, as well as through relaxivity measurements using the High Field Magnetic Lab at Penn State directed by Dr. Thomas Neuberger.