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Author: Swati Gupta Publisher: Springer Nature ISBN: 3030841642 Category : Medical Languages : en Pages : 550
Book Description
The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders. Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.
Author: Swati Gupta Publisher: Springer Nature ISBN: 3030841642 Category : Medical Languages : en Pages : 550
Book Description
The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders. Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.
Author: Katherine Gonzáles Rojas Publisher: ISBN: Category : Languages : de Pages : 0
Book Description
The treatment of intracellularly residing pathogens is a challenge of modern medicine. These pathogens are able to hide from the host immune system by residing intracellularly in different types of endosomes or the cytoplasm thereby interfering with the immune response of phagocytic cells. Aspergillus fumigatus is a clinically important fungal pathogen that causes severe systemic infections. Conidia of this fungus are able to survive inside macrophages for some time. In order to treat this pathogen, we have developed a strategy using drug delivery systems to overcome the cell membrane and phagosomal membrane to reach conidia residing in phagolysosomes of macrophages. Here, we provide evidence that targeting of intracellular conidia is possible with polymeric particles of 800 nm size. These particles were fluorescently labeled and their uptake by infected macrophages was studied. Particle delivery to conidia-containing phagolysosomes was confirmed by different microscopic methods and the generation of transfected cell lines. Targeting occurs by fusion of phagolysosomes containing conidia with phagolysosomes containing the particle, as it was demonstrated by presence of phagolysosomal markers on phagosomes containing both conidia and particles. In order to enhance the fusion frequency, several compounds were tested that affected the lipid composition of the phago(lyso)some and its maturation. Based on these proof-of-concept results, smart drug delivery systems carrying antifungal activity were developed. In a first step, macromolecules such as polymer-caspofungin conjugates were generated. They showed antifungal activity as macromolecule, although the drug was not released. By comparison, drug release was demonstrated with a polymer-voriconazole conjugate, linked by a cathepsin B-sensitive peptide. Taken together, this thesis demonstrates the potential of drug delivery systems to target intracellularly residing pathogens in macrophages with antibiotics.
Author: Ethan S. Smith Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
The design of quantification tools for both macrophage differentiation and nanoparticle uptake along with a design for a proposed coculture model with lung epithelial cells could help to create a more realistic dynamic model for respiratory cancer and diseases.
Author: Padma V. Devarajan Publisher: Springer Nature ISBN: 3030291685 Category : Medical Languages : en Pages : 560
Book Description
This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.
Author: Heather A. E. Benson Publisher: John Wiley & Sons ISBN: 1119769604 Category : Medical Languages : en Pages : 580
Book Description
A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Author: Jorge Coelho Publisher: Springer Science & Business Media ISBN: 9400760108 Category : Medical Languages : en Pages : 433
Book Description
This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.
Author: Sonke Svenson Publisher: Springer ISBN: 9781489999368 Category : Technology & Engineering Languages : en Pages : 374
Book Description
This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. This book, unlike others covering nanoparticles used in medical applications, presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.
Author: Swati Gupta
Author: Swati Gupta
Author: Katherine Gonzáles Rojas
Author: Ethan S. Smith
Author: Padma V. Devarajan
Author: Heather A. E. Benson
Author: Sami Ullah
Author: Jorge Coelho
Author: Sonke Svenson
Author: Shardool Jain
Author: Sascha Eichendorff