Author: Wayne A. HendricksonPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Macromolecular Structures
Author: Wayne A. HendricksonMacromolecular Structures 1991
Author: Wayne A. HendricksonPublisher:
ISBN:
Category : Macromolecules
Languages : en
Pages : 316
Book Description
Macromolecular structures
Author: Wayne A. HendricksonPublisher:
ISBN:
Category :
Languages : en
Pages : 104
Book Description
Microcalorimetry of Macromolecules
Author: Peter L. PrivalovPublisher: John Wiley & Sons
ISBN: 111810451X
Category : Science
Languages : en
Pages : 420
Book Description
Examining the physical basis of the structure of macromolecules—proteins, nucleic acids, and their complexes—using calorimetric techniques Many scientists working in biology are unfamiliar with the basics of thermodynamics and its role in determining molecular structures. Yet measuring the heat of structural change a molecule undergoes under various conditions yields information on the energies involved and, thus, on the physical bases of the considered structures. Microcalorimetry of Macromolecules offers protein scientists unique access to this important information. Divided into thirteen chapters, the book introduces readers to the basics of thermodynamics as it applies to calorimetry, the evolution of the calorimetric technique, as well as how calorimetric techniques are used in the thermodynamic studies of macromolecules, detailing instruments for measuring the heat effects of various processes. Also provided is general information on the structure of biological macromolecules, proteins, and nucleic acids, focusing on the key thermodynamic problems relating to their structure. The book covers: The use of supersensitive calorimetric instruments, including micro and nano-calorimeters for measuring the heat of isothermal reactions (Isothermal Titration Nano-Calorimeter), the heat capacities over a broad temperature range (Scanning Nano-Calorimeter), and pressure effects (Pressure Perturbation Nano-Calorimeter) Two of the simplest but key structural elements: the α and polyproline helices and their complexes, the α-helical coiled-coil, and the pyroline coiled-coils Complicated macromolecular formations, including small globular proteins, multidomain proteins and their complexes, and nucleic acids Numerous examples of measuring the ground state of protein energetics, as well as changes seen when proteins interact The book also reveals how intertwined structure and thermodynamics are in terms of a macromolecule's organization, mechanism of formation, the stabilization of its three-dimensional structure, and ultimately, its function. The first book to describe microcalorimetric technique in detail, enough for graduate students and research scientists to successfully plumb the structural mysteries of proteins and the double helix, Microcalorimetry of Macromolecules is an essential introduction to using a microcalorimeter in biological studies.
Direct Methods for Solving Macromolecular Structures
Author: S. FortierPublisher: Springer Science & Business Media
ISBN: 9401590931
Category : Science
Languages : en
Pages : 505
Book Description
This book of the proceedings of the 1997 NATO Advanced Study Institute (ASI) on Direct Methods for Solving Macromolecular Structures was assembled from the lecturers' contributions and represents a comprehensive and in-depth overview of crystallographic structure determination methods for macromolecules. While having a focus based on the direct methods, the Institute adopted an inclusive and broad perspective. Thus, both direct and experimental phasing techniques are presented in this book, highlighting their complementarities and synergies. As weil, methodologies spanning the full crystallographic image reconstruction process - from low resolution envelope definition to high resolution atomic refinement- are discussed. The first part of the book introduces the array of tools currently used in structure determination, whether originating from a mathematical, computational or experimental framework. This section of the book displays the variety and ingenuity of old and new phasing approaches developed to solve increasingly complex structures. Some of the contributions focus on recent developments and/or implementations that have given older approaches a new life. A case in point is the re-implementation of Buerger's superposition approach, which is now solving protein structures. Another beautiful example is found in the introduction to the traditional multiple isomorphous replacement approach where new techniques, such as site-directed mutagenesis and the use of inert gases in the preparation of heavy atom derivatives, are described. Equally impressive are the presentations of newer approaches, which take advantage of advances on the experimental front (e. g.
Hierarchical Macromolecular Structures: 60 Years after the Staudinger Nobel Prize I
Author: Virgil PercecPublisher: Springer
ISBN: 3319011375
Category : Technology & Engineering
Languages : en
Pages : 434
Book Description
Advances in Polymer Science enjoys a longstanding tradition and good reputation in its community. Each volume is dedicated to a current topic, and each review critically surveys one aspect of that topic, to place it within the context of the volume. The volumes typically summarize the significant developments of the last 5 to 10 years and discuss them critically, presenting selected examples, explaining and illustrating the important principles, and bringing together many important references of primary literature. On that basis, future research directions in the area can be discussed. Advances in Polymer Science volumes thus are important references for every polymer scientist, as well as for other scientists interested in polymer science - as an introduction to a neighboring field, or as a compilation of detailed information for the specialist.
Hierarchical Macromolecular Structures: 60 Years after the Staudinger Nobel Prize II
Author: Virgil PercecPublisher: Springer
ISBN: 3319037196
Category : Technology & Engineering
Languages : en
Pages : 460
Book Description
Advances in Polymer Science enjoys a longstanding tradition and good reputation in its community. Each volume is dedicated to a current topic and each review critically surveys one aspect of that topic, to place it within the context of the volume. The volumes typically summarize the significant developments of the last 5 to 10 years and discuss them critically, presenting selected examples, explaining and illustrating the important principles and bringing together many important references of primary literature. On that basis, future research directions in the area can be discussed. Advances in Polymer Science volumes thus are important references for every polymer scientist as well as for other scientists interested in polymer science - as an introduction to a neighboring field, or as a compilation of detailed information for the specialist.
Macromolecular Structures
Author: Wayne A.. HendricksonPublisher:
ISBN:
Category :
Languages : en
Pages : 369
Book Description
Macromolecules
Author: Hans-Georg EliasPublisher: Springer Science & Business Media
ISBN: 1461573645
Category : Technology & Engineering
Languages : en
Pages : 1228
Book Description
Like so many of its kind, this textbook originated from the requirements of teaching. While lecturing on macromolecular science as a required subject for chemists and materials scientists on the undergraduate, graduate, and postgraduate levels at Swiss Federal Institute of Technology at Zurich (1960-1971), I needed a one-volume textbook which treated the whole field of macromolecular science, from its chemistry and physics to its applications, in a not too elementary manner. This textbook thus intends to bridge the gap between the often oversimplified introductory books and the highly specialized texts and monographs that cover only parts of macromolecular science. This first English edition is based on the third German edition (1975), which is about 40% different from the first German edition (1971), a result of rapid progress in macromolecular science and the less rapid education of the writer. This text intends to survey the whole field of macromolecular science. Its organization results from the following considerations. The chemical structure of macromolecular compounds should be independent of the method of synthesis, at least in the ideal case. Part I is thus concerned with the chemical and physical structure of macro molecules. Properties depend on structure. Solution properties are thus discussed in Part II, solid state properties in Part III. There are other reasons for discussing properties before syntheses: For example, it is difficult to under stand equilibrium polymerization without knowledge of solution thermody of the glass temperature, etc.
Author: