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Author: Eric Holtzman Publisher: Springer Science & Business Media ISBN: 1489925406 Category : Science Languages : en Pages : 454
Book Description
In 1976 I wrote a monograph on lysosomes (Lysosomes: A Survey, Springer Verlag, Vienna) that was intended as an up-to-date, comprehensive survey. Whatever success I may have achieved then in fulfilling that intention, even the effort now would be foolhardy. The literature has grown so rapidly in the past decade that I certainly could not even read all of the essential papers, let alone understand and analyze them. My goal here, therefore, is simply to introduce the major features of lysosomes at a level I hope will be useful both to I;ldvanced students and to researchers interested in obtaining a broad background. This is in keeping with the design of the Cellular Organelles series: the series is more a set of advanced texts than of review monographs. This design carries with it the decision not to support each point by refer ences to the original literature. I apologize for the injustice involved in such a decision but feel that in any event it would be impossibly unwieldy to cite, adequately and in a balanced manner, the contributions of the vast network of researchers responsible for the information upon which I draw.
Author: Eric Holtzman Publisher: Springer Science & Business Media ISBN: 1489925406 Category : Science Languages : en Pages : 454
Book Description
In 1976 I wrote a monograph on lysosomes (Lysosomes: A Survey, Springer Verlag, Vienna) that was intended as an up-to-date, comprehensive survey. Whatever success I may have achieved then in fulfilling that intention, even the effort now would be foolhardy. The literature has grown so rapidly in the past decade that I certainly could not even read all of the essential papers, let alone understand and analyze them. My goal here, therefore, is simply to introduce the major features of lysosomes at a level I hope will be useful both to I;ldvanced students and to researchers interested in obtaining a broad background. This is in keeping with the design of the Cellular Organelles series: the series is more a set of advanced texts than of review monographs. This design carries with it the decision not to support each point by refer ences to the original literature. I apologize for the injustice involved in such a decision but feel that in any event it would be impossibly unwieldy to cite, adequately and in a balanced manner, the contributions of the vast network of researchers responsible for the information upon which I draw.
Author: Frederick R. Maxfield Publisher: John Wiley & Sons ISBN: 1118645154 Category : Medical Languages : en Pages : 561
Book Description
Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development
Author: Pooja Dhiman Publisher: BoD – Books on Demand ISBN: 9535135074 Category : Science Languages : en Pages : 176
Book Description
This book covers current advances in disorders associated with lysosomal function along with techniques to study its function. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on lysosomal diseases and opens new possible research paths.
Author: P. Matile Publisher: Springer Science & Business Media ISBN: 3709183995 Category : Science Languages : en Pages : 193
Book Description
Almost twenty years ago DE DuvE discovered the existence in rat liver cells of a novel class of subcellular structures which he termed lysosomes. As the lysosomes are the seat of various hydrolytic enzymes this discovery greatly stimulated the interest in cellular digestive processes. It is now recognized that compartmentation of hydrolases is an outstanding example of the dependence of metabolic functions on cell structure. The important role of lytic processes in plant metabolism made it interesting to correlate the facts on the various phenomena and present them from the point of view of cellular compartmentation. It is not intended to survey in extenso the litera ture on the various aspects of localization and function of hydrolases in plant cells as this would be an impossible task. The aim of this monograph is to emphasize the significance of hydrolase compartmentation rather than to strive for complete coverage of work on hydrolases in which other viewpoints have been considered. I thank Miss SONIA TURLER for her great help with the manuscript. I also wish to acknowledge the assistance given by Dr. ELSA HAUSERMANN, Mrs. DORLI FURRER, and Mrs. SILVIA STUNZI. Moreover, I am indebted to my collaborators and particularly to my colleague Dr. A. WIEMKEN for frequent and stimulating discussions on the subject. Zurich (Switzerland), February 1975 PH. MATILE Contents Abbreviations . XIII Introduction: Lysis and the Lytic Compartment. 1 1. Hydrolases and their Localization . . . . . 3 1. 1. Classification and Properties of Hydrolases 3 1. 1. 1. Peptidases . . . . . . . . .
Author: Donald B. Roodyn Publisher: Springer Science & Business Media ISBN: 1461579457 Category : Science Languages : en Pages : 538
Book Description
This volume continues the tradition of SUBCELLULAR BIOCHEMISTRY of trying to break down interdisciplinary barriers in the study of cell function and of bringing the reader's attention to less well studied, but nevertheless useful, biological systems. We start with an extensive article by T. P. Karpetsky, M. S. Boguski and C. C. Levy on the structure, properties and possible functions of polyadenylic acid. Apart from revealing a general lack of appreciation of many important aspects of the chemical properties of poly adenylic acid, the literature also shows that there is a great gulf between those who study the biological role of polyadenylic acid. and those who study its physicochemi cal properties. The article by Karpetsky and his colleagues is an attempt to overcome this lack of communication and to present an integrated view of the subject. The authors go into the subject in full detail and the more biologically inclined reader may on occasion have to reread his nucleic acid physical chemistry notes! However, the effort is worthwhile and the article is a timely reminder that we cannot treat nucleic acids as mere abstractions, but that they are complex organic macromolecules capable of equally complex, but nevertheless important, interactions. The next article is by J. Steensgaard and N. P. Hundahl M0ller and deals with computer simulation of density gradient centrifugation systems.
Author: Frederick R. Maxfield Publisher: John Wiley & Sons ISBN: 1118978315 Category : Medical Languages : en Pages : 586
Book Description
Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development
Author: Deborah Elstein Publisher: Springer Science & Business Media ISBN: 9048190339 Category : Medical Languages : en Pages : 525
Book Description
Fabry disease is an X-linked inborn error of metabolism wherein deficiency of a lysosomal enzyme results in systemic deposition of glycosphingolipids. Storage deposition, and hence pathological disease, occurs preferentially in renal glomerular and tubular epithelial cells, myocardial cells, heart valve fibrocytes, neurons of dorsal root ganglia, and in endothelial smooth muscle cells of blood vessels. Thus, Fabry disease is a multi-system disorder, albeit with considerable phenotypic heterogeneity in onset and in severity; however, it is progressive, exhibits extensive morbidity, and is life-threatening. Within the past two decades, there has been a radical change in the natural course Fabry disease by virtue of the availability of specific enzyme replacement therapy. Moreover, there has been a concerted effort to better understand the underlying pathology and equally to identify patients prior to the onset of irreversible end-organ damage. It is to be hoped that the future for patients with Fabry disease can be viewed with greater, albeit guarded, optimism. This state-of-the-art textbook attempts to bridge the span of pre-clinical studies, clinical finding, and management options in a readable but comprehensive manner for the medical practitioner as well as the interested non-medical reader.
Author: Eric Holtzman
Author: Eric Holtzman
Author: E Holtzman
Author: Frederick R. Maxfield
Author: K. Aterman
Author: Pooja Dhiman
Author: P. Matile
Author: J. Gordon Betts
Author: Donald B. Roodyn
Author: Frederick R. Maxfield
Author: Deborah Elstein