Author: Ilan SamishPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Local Structural Motifs Involved in Helical Membrane Protein Assembly and Dynamic Function
Author: Ilan SamishMembrane Protein Structure
Author: Stephen H WhitePublisher: Springer
ISBN: 1461475155
Category : Science
Languages : en
Pages : 403
Book Description
Studies of receptors, ion channels, and other membrane proteins require a solid understanding of the structural principles of these important biomolecules. Membrane protein structure is, however, a very challenging field. The structures of only three types of transmembrane proteins have been determined to moderate or high resolution during the last two decades, a period during which the amino acid sequences of hundreds, if not thousands, of membrane proteins have been reported. As a result, the creation of structural models to serve as guides for studies of receptors, channels, and other membrane proteins has become crucially important. This book has been assembled in order to share the experiences and findings of expert researchers in protein structure and structure-prediction methods as well as membrane biophysics and lipid physical chemistry, whose work establishes the basis for the development of suitable model structures. The reviews presented here emphasize fundamental ideas and provide an entry to the diverse and complex literature. The four major sections deal with the general nature of the membrane protein structure problem, biochemical and molecular biological approaches to protein topology, direct structural methods, and model and physicochemical approaches. The work will be of interest to physiologists, cellular and molecular biologists, biophysicists, and biochemists working on the function of membrane proteins such as receptors, ion channels, and transporters, as well as senior graduate students and independent investigators.
Helix Association and Dynamic Motifs in Membrane Protein Folding
Author: Alessandro SenesMembrane Protein Assembly
Author: Gunnar von HeijnePublisher: R. G. Landes
ISBN:
Category : Science
Languages : en
Pages : 300
Book Description
Study of Bacteriorhodopsin in a Controlled Lipid Environment
Author: Vivien YehPublisher: Springer
ISBN: 9811312389
Category : Science
Languages : en
Pages : 139
Book Description
This book focuses on the study of how the properties of nanodiscs, such as lipid composition and size, influence the function of the embedding integral membrane protein, bacteriorhodopsin. The author performed systematic studies to show that the lipid composition and the charge of the hydrophobic head and the structure of hydrophilic tails affect the photocycle pathway of bacteriorhodopsin, which is closely associated with its proton-pumping activity. Furthermore, the author demonstrated a highly efficient method for extracting membrane proteins directly from the biological membrane, preserving protein conformation, function and essential native lipids. This book demonstrates optimization and sample preparation, and presents practical methods of preparing membrane protein-embedded nanodisc samples for biophysical studies, which benefit structural and functional studies in the field of membrane protein characterization, both.
Molecular Biology of The Cell
Author: Bruce AlbertsPublisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
Book Description
Peptide-Lipid Interactions
Author: Sidney A. SimonPublisher: Academic Press
ISBN: 0080925855
Category : Science
Languages : en
Pages : 606
Book Description
This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion. Key Features * world-renowned experts * state-of-the-art experimental methods * monolayers, bilayers, biological membranes * theoretical aspects and computer simulations * rafts * synaptic transmission * membrane fusion * signal transduction
Protein Structure and Modeling
Author: Natalya KurochkinaPublisher: Springer
ISBN: 9811366012
Category : Science
Languages : en
Pages : 276
Book Description
This book will consider principles of the organization of protein molecules, the relationships between primary, secondary, and tertiary structure, the determinants of protein conformation, and the applications of structure determination and structure modeling in biomedical research.
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