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Author: Eva B. Vedel Jensen Publisher: World Scientific ISBN: 9789810224547 Category : Mathematics Languages : en Pages : 272
Book Description
This book provides a unified exposition of local-stereological methods developed within the last 15 years. The object of local stereology is to draw inference about quantitative parameters of spatial structures which can be regarded as neighbourhoods of points, called reference points. The model example is a biological cell which can be regarded as a neighbourhood of its nucleus. In local stereology, information from sections through the reference point is used. Only very weak assumptions are needed for the structure under study. For instance, specific cell shape assumptions are not necessary.In order to reach a broader audience, the book has been written not only for specialists in stereology, integral geometry and geometric measure theory. In particular, Chapter 1 is an elementary introduction to stereology and the book contains about 75 illustrations. The theory of local steroelogy involves, however, advanced mathematical tools, which constitute an important part of the book.Local-stereological methods are now in world-wide use in the microscopical study of biological tissue, and this invaluable book also contains a description of how the local methods are used in practice.
Author: Eva B. Vedel Jensen Publisher: World Scientific ISBN: 9789810224547 Category : Mathematics Languages : en Pages : 272
Book Description
This book provides a unified exposition of local-stereological methods developed within the last 15 years. The object of local stereology is to draw inference about quantitative parameters of spatial structures which can be regarded as neighbourhoods of points, called reference points. The model example is a biological cell which can be regarded as a neighbourhood of its nucleus. In local stereology, information from sections through the reference point is used. Only very weak assumptions are needed for the structure under study. For instance, specific cell shape assumptions are not necessary.In order to reach a broader audience, the book has been written not only for specialists in stereology, integral geometry and geometric measure theory. In particular, Chapter 1 is an elementary introduction to stereology and the book contains about 75 illustrations. The theory of local steroelogy involves, however, advanced mathematical tools, which constitute an important part of the book.Local-stereological methods are now in world-wide use in the microscopical study of biological tissue, and this invaluable book also contains a description of how the local methods are used in practice.
Author: Adrian Baddeley Publisher: CRC Press ISBN: 1135438366 Category : Mathematics Languages : en Pages : 412
Book Description
Setting out the principles of stereology from a statistical viewpoint, this book focuses on both basic theory and practical implications. The authors discuss ways to effectively communicate statistical issues to clients, draw attention to common methodological errors, and provide references to essential literature. The first full text on design-based stereology opens with a review of classical and modern stereology, followed by a treatment of mathematical foundations and then on to core techniques. The final chapters discuss implementing techniques in practical sampling designs, summarize understanding of the variance of stereological estimators, and describe open problems for further research. The book also details isotropic, vertical or local sampling designs for estimating stereological parameters such as volume, surface area, particle number and spatial distribution. This extensive text offers support to statistical consultants using examples, applications and unique Advice to Consultants sections. It contains numerous literature references, bibliographic notes and nearly 150 illustrations.
Author: Mark J. West Publisher: ISBN: 9781936113606 Category : Autonomic nervous system Languages : en Pages : 0
Book Description
Stereological techniques allow biologists to create quantitative, three-dimensional descriptions of biological structures from two- dimensional images of tissue viewed under the microscope. For example, they can accurately estimate the size of a particular organelle, the total length of a mass of capillaries, or the number of neurons or synapses in a particular region of the brain. This book provides a practical guide to designing and critically evaluating stereological studies of the nervous system and other tissues. It explains the basic concepts behind design-based stereology and how to get started. Also included are detailed descriptions of how to prepare tissue appropriately, perform pilot studies and decide on the appropriate sampling strategy, and account for phenomena such as tissue shrinkage. Numerous examples of applications of stereological methods that are applicable to studies of the central system and a wide variety of other tissues are explained. The book is therefore essential reading for neurobiologists and cell biologists interested in generating accurate representations of cell and tissue architecture.
Author: Peter R. Mouton Publisher: JHU Press ISBN: 1421402289 Category : Medical Languages : en Pages : 249
Book Description
This update to Peter R. Mouton’s pioneering work provides bioscientists with the concepts needed in order to apply the principles and practices of unbiased stereology to research involving biological tissues. Mouton starts with a brief explanation of the history and theory of the process before defining the terms, concepts, and tools of unbiased stereological procedures. He compares and contrasts the procedures with less-exacting approaches to quantitative analysis of biological structure using specific examples from biomedical literature. The book incorporates existing best practices with new methodologies, such as the Rare Event Protocol, while simplifying the dense, often difficult literature on the subject to show the utility and importance of unbiased stereology. This clear, insightful guide goes a step further than other books on this subject by demonstrating not only how to use unbiased stereology but also how to interpret and present the results. Written by the official U.S. representative to the International Society for Stereology, this is the most complete, up-to-date resource on the science of unbiased stereology. Those new to bioscience research as well as experienced practitioners will find that Mouton’s explanations are the perfect companion for stereology courses and workshops.
Author: Adrian Baddeley Publisher: CRC Press ISBN: 0203496817 Category : Mathematics Languages : en Pages : 394
Book Description
Setting out the principles of stereology from a statistical viewpoint, this book focuses on both basic theory and practical implications. The authors discuss ways to effectively communicate statistical issues to clients, draw attention to common methodological errors, and provide references to essential literature. The first full text on design-bas
Author: Vyvyan Howard Publisher: Garland Science ISBN: 0203006399 Category : Medical Languages : en Pages : 277
Book Description
Unbiased Stereology, Second Edition is a practical guide to making unbiased 3-D measurements via the microscope. Only those stereological techniques which have been tried and tested by real application are included. Although this technology is essentially mathematical and statistical, the authors do not immerse the reader in complex analysis, but rather provide simple heuristic explanations and references to the original proof, and illustrate the theory by analogies drawn from everyday experience. To give practical experience in application of the techniques, exercises are provided at the end of each chapter, complete with detailed worked answers.
Author: Anil V. Parwani Publisher: Springer Nature ISBN: 3030833321 Category : Medical Languages : en Pages : 253
Book Description
This book provides up-to-date and practical knowledge in all aspects of whole slide imaging (WSI) by experts in the field. This includes a historical perspective on the evolution of this technology, technical aspects of making a great whole slide image, the various applications of whole slide imaging and future applications using WSI for computer-aided diagnosis The goal is to provide practical knowledge and address knowledge gaps in this emerging field. This book is unique because it addresses an emerging area in pathology for which currently there is only limited information about the practical aspects of deploying this technology. For example, there are no established selection criteria for choosing new scanners and a knowledge base with the key information. The authors of the various chapters have years of real-world experience in selecting and implementing WSI solutions in various aspects of pathology practice. This text also discusses practical tips and pearls to address the selection of a WSI vendor, technology details, implementing this technology and provide an overview of its everyday uses in all areas of pathology. Chapters include important information on how to integrate digital slides with laboratory information system and how to streamline the “digital workflow” with the intent of saving time, saving money, reducing errors, improving efficiency and accuracy, and ultimately benefiting patient outcomes. Whole Slide Imaging: Current Applications and Future Directions is designed to present a comprehensive and state-of the-art approach to WSI within the broad area of digital pathology. It aims to give the readers a look at WSI with a deeper lens and also envision the future of pathology imaging as it pertains to WSI and associated digital innovations.
Author: Stephen M. Evans Publisher: ISBN: 9780198505280 Category : Medical Languages : en Pages : 362
Book Description
Stereology is a valuable tool for neuroscientists, allowing them to obtain 3-Dimensional information from 2-Dimensional measurements made on appropriately sampled sections (usually obtained from histological sections or MRI/CT/PET scans). This 3-D information is invaluable in correlatingstructural/functional relationships in the pursuit of far greater understanding of the function of the central nervous system. However, in carrying out such measurements, often based on limited data sets, there is a risk of experimenter bias. An important feature of modern design based stereology isto be aware of potential sources of bias and eliminate them during the data collection. With many of the major neuroscience journals now insisting that quantitative data be presented, there is a greater need than ever for neuroscientists to understand the theory and practice behind quantitativemethods, such as those offered by stereology. Quantitative Methods in Neuroscience is a cookbook of stereological methods written especially for neuroscientists. It provides clear and accessible advice about when and when not to use stereology. Throughout the book, the emphasis is on practical guidance, rather than discussions and formulae.Written by leading scientists in the field of stereology, with a Foreword by D.C. Sterio, the book will be a valuable introduction to these methods for neuroscientists, and all those involved in development of new drug programmes.
Author: Eva B. Vedel Jensen
Author: Eva B. Vedel Jensen
Author: Adrian Baddeley
Author: Mark J. West
Author: Peter R. Mouton
Author: Adrian Baddeley
Author: Vyvyan Howard
Author: Jack Glaser
Author: Anil V. Parwani
Author: 
Author: Stephen M. Evans