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Author: Udo R. Markert Publisher: Karger Medical and Scientific Publishers ISBN: 3805575319 Category : Health & Fitness Languages : en Pages : 153
Book Description
The incidence of allergies is increasing worldwide. Beside the well-established symptomatic treatments and subcutaneous immunotherapies, formerly known as de- or hyposensitization, a new form of treatment, local immunotherapy, has been developed in recent years. Local immunotherapy, though still controversially discussed, promises to be a curative, noninvasive, and easily applicable treatment for allergies. This volume summarizes the most current information on local immunotherapy compiled by internationally renowned specialists. In the methodology section, general aspects of local immunotherapy are presented including its history, allergen resorption and biodistribution, mechanisms of oral tolerance and practical experiences. The second section devoted to efficacy and safety presents findings from international placebo-controlled studies on nasal and sublingual immunotherapies with different allergens and for different allergic conditions including asthma and eczema. Possible side effects are also discussed. The concluding chapter critically evaluates the future prospects of this new method, pointing out still unresolved issues such as the exact immunological mechanisms, its long-term effects, or the standardization of dose and application intervals/duration. This state-of-the-art account will be of particular interest to scientists working in the field of allergy, clinical allergologists, pharmacists, and representatives from the pharmaceutical industry.
Author: Udo R. Markert Publisher: Karger Medical and Scientific Publishers ISBN: 3805575319 Category : Health & Fitness Languages : en Pages : 153
Book Description
The incidence of allergies is increasing worldwide. Beside the well-established symptomatic treatments and subcutaneous immunotherapies, formerly known as de- or hyposensitization, a new form of treatment, local immunotherapy, has been developed in recent years. Local immunotherapy, though still controversially discussed, promises to be a curative, noninvasive, and easily applicable treatment for allergies. This volume summarizes the most current information on local immunotherapy compiled by internationally renowned specialists. In the methodology section, general aspects of local immunotherapy are presented including its history, allergen resorption and biodistribution, mechanisms of oral tolerance and practical experiences. The second section devoted to efficacy and safety presents findings from international placebo-controlled studies on nasal and sublingual immunotherapies with different allergens and for different allergic conditions including asthma and eczema. Possible side effects are also discussed. The concluding chapter critically evaluates the future prospects of this new method, pointing out still unresolved issues such as the exact immunological mechanisms, its long-term effects, or the standardization of dose and application intervals/duration. This state-of-the-art account will be of particular interest to scientists working in the field of allergy, clinical allergologists, pharmacists, and representatives from the pharmaceutical industry.
Author: Jean Bousquet Publisher: CRC Press ISBN: 9780824701765 Category : Medical Languages : en Pages : 0
Book Description
This massive reference thoroughly analyzes the mechanisms implicated in the pathophysiology of asthma, such as T helper lymphocyte subsets, and the consequences of various extrinsic and intrinsic factors, and IgE receptor expression-reviewing current concepts in immunotherapeutic approaches for the treatment of this and other allergic diseases. Investigates the only category of treatment showing the potential to affect the natural course of allergic diseases and prevent the onset of asthma. Written by more than 80 internationally renowned pulmonary experts, allergic disease specialists, and basic researchers, Immunotherapy in Asthma discusses the efficacy of new medications examines the role of metachromatic cells, lymphocytes, macrophages, and other cell types present in bronchial biopsies presents basic topics such as the functional and phenotypic properties of Th1 and Th2 cells and their role in allergic disease and the regulation of IgE-mediated inflammatory responses addresses the deleterious effects of smoking and passive exposure to cigarette smoke in children and adults assesses differences and similarities between intrinsic and antigen-induced asthma describes the effects of immunogenic peptides on the cytokine production profile of allergen-specific CD4+ T cells explains the different clinical aspects of allergic responses, such as bronchial hyperreactivity and eosinophilic inflammation of the airways reviews the genetic basis of allergy, as well as risk factors for asthma explores oral, sublingual, local nasal, and local bronchial routes for noninjective immunotherapies evaluates various agents with modulatory effects on normal and pathogenic immune responses focuses on strategies for the prevention of childhood asthma and more! Containing over 3000 references, drawings, and tables, Immunotherapy in Asthma is an indispensable resource for pulmonologists, immunologists, allergists, and medical school students in these disciplines.
Author: Jean Bousquet Publisher: CRC Press ISBN: 9780824701765 Category : Medical Languages : en Pages : 0
Book Description
This massive reference thoroughly analyzes the mechanisms implicated in the pathophysiology of asthma, such as T helper lymphocyte subsets, and the consequences of various extrinsic and intrinsic factors, and IgE receptor expression-reviewing current concepts in immunotherapeutic approaches for the treatment of this and other allergic diseases. Investigates the only category of treatment showing the potential to affect the natural course of allergic diseases and prevent the onset of asthma. Written by more than 80 internationally renowned pulmonary experts, allergic disease specialists, and basic researchers, Immunotherapy in Asthma discusses the efficacy of new medications examines the role of metachromatic cells, lymphocytes, macrophages, and other cell types present in bronchial biopsies presents basic topics such as the functional and phenotypic properties of Th1 and Th2 cells and their role in allergic disease and the regulation of IgE-mediated inflammatory responses addresses the deleterious effects of smoking and passive exposure to cigarette smoke in children and adults assesses differences and similarities between intrinsic and antigen-induced asthma describes the effects of immunogenic peptides on the cytokine production profile of allergen-specific CD4+ T cells explains the different clinical aspects of allergic responses, such as bronchial hyperreactivity and eosinophilic inflammation of the airways reviews the genetic basis of allergy, as well as risk factors for asthma explores oral, sublingual, local nasal, and local bronchial routes for noninjective immunotherapies evaluates various agents with modulatory effects on normal and pathogenic immune responses focuses on strategies for the prevention of childhood asthma and more! Containing over 3000 references, drawings, and tables, Immunotherapy in Asthma is an indispensable resource for pulmonologists, immunologists, allergists, and medical school students in these disciplines.
Author: Linda S. Coz Publisher: Elsevier ISBN: 9780323718547 Category : Languages : en Pages : 240
Book Description
This issue of Immunology and Allergy Clinics, guest edited by Drs. Linda S. Cox and Anna Nowak-Wegrzyn, is devoted to Immunotherapy for Aeroallergens, Foods, and Venoms. Articles in this issue include: Mechanism of Immunotherapy: Focus SCIT and SLIT; Subcutaneous Immunotherapy Safety: Incidence per surveys and risk factors; Sublingual Immunotherapy for Other Indications: Venom large local, latex, atopic dermatitis and food; Questions and Controversies regarding venom immunotherapy; Socioeconomics or Comparative Effectiveness of Immunotherapy; Risk Reduction in Peanut Immunotherapy; Food OIT with Adjuvants; Peanut OIT: State of the art; Evolution of Immune Responses in Food Immunotherapy; Safety of Food Oral Immunotherapy: What we know and what we need to learn; Novel Vaccines for Food Allergy; IgG and IgE in Food Allergy - What's the connection?; and Sublingual and Patch Immunotherapy for Food Allergy.
Author: Taylor & Francis Group Publisher: CRC Press ISBN: 9781032173276 Category : Languages : en Pages : 600
Book Description
The sixth edition of Lockey and Ledford's Allergens and Allergen Immunotherapy continues to provide comprehensive coverage of all types of allergens and allergen vaccines, providing clinicians the essential information they need to accurately diagnose and manage all allergic conditions. With new and updated chapters, the sixth edition is the most up-to-date, single resource on allergy and immunotherapy. Key Features Completely revised and updated Detailed single source reference on allergy and immunotherapy Reorganized to provide clinicians with essential information to make diagnoses and offer the best treatments
Author: Kari Nadeau MD, PhD Publisher: Penguin ISBN: 0593189523 Category : Health & Fitness Languages : en Pages : 354
Book Description
A life-changing, research-based program that will end food allergies in children and adults forever. The problem of food allergy is exploding around us. But this book offers the first glimpse of hope with a powerful message: You can work with your family and your doctor to eliminate your food allergy forever. The trailblazing research of Dr. Kari Nadeau at Stanford University reveals that food allergy is not a life sentence, because the immune system can be retrained. Food allergies--from mild hives to life-threatening airway constriction--can be disrupted, slowed, and stopped. The key is a strategy called immunotherapy (IT)--the controlled, gradual reintroduction of an allergen into the body. With innovations that include state-of-the-art therapies targeting specific components of the immune system, Dr. Nadeau and her team have increased the speed and effectiveness of this treatment to a matter of months. New York Times bestselling author Sloan Barnett, the mother of two children with food allergies, provides a lay perspective that helps make Dr. Nadeau's research accessible for everyone. Together, they walk readers through every aspect of food allergy, including how to find the right treatment and how to manage the ongoing fear of allergens that haunts so many sufferers, to give us a clear, supportive plan to combat a major national and global health issue.
Author: Publisher: ISBN: Category : Languages : en Pages : 45
Book Description
Respiratory allergic diseases (also known as allergies), such as rhinitis, asthma, and conjunctivitis, affect more than 400 million people globally and are on the rise in industrialized countries. Allergies result from hypersensitivity to various allergens, such as airborne particles, food, and venom. Mild forms of allergies can be treated with pharmacotherapy (in the form of antihistamines or corticosteroids), but moderate-to-severe allergic reactions require specific allergen immunotherapy (SIT). SIT involves administering gradually increasing doses of extracts of the causative allergen to which a patient is hypersensitive. The aim of treatment is to reduce the clinical reactions of allergic patients. Alternative forms of SIT for respiratory allergies include intralymphatic immunotherapy (ILIT), oral immunotherapy (OIT), local nasal immunotherapy (LNIT), and sublingual immunotherapy (SLIT). The purpose of this Rapid Response report is to review the evidence of comparative clinical effectiveness and cost-effectiveness of subcutaneous (or injectable) immunotherapy (SCIT), sublingual immunotherapy (SLIT), and oral antihistamines in patients with allergies, and to identify published, evidence-based guidelines on the use of SCIT or SLIT for allergies.
Author: U. S. Department of Health and Human Services Publisher: Createspace Independent Pub ISBN: 9781489521620 Category : Medical Languages : en Pages : 494
Book Description
Allergic rhinitis is a widespread clinical problem, estimated to affect 20 to 40 percent of the population in the U.S. Inhalant allergens, such as plant pollens, characteristically cause seasonal rhinoconjunctivitis and/or asthma; whereas, cat dander, cockroaches, or dust mite allergens may induce symptoms year-round, and are associated with perennial rhinitis and/or asthma. The prevalence of asthma in the U.S. is approximately 9 percent, and approximately 62 percent of individuals with asthma show evidence of also having atopy (i.e., one or more positive-specific IgE levels). The medical management of patients with allergic rhinitis and asthma includes allergen avoidance, pharmacotherapy, and immunotherapy. Allergen-specific immunotherapy (SIT) is typically recommended for patients whose allergic rhinoconjunctivitis and asthma symptoms cannot be controlled by medication and environmental controls, for patients who cannot tolerate medications, or for patients who do not comply with chronic medication regimens. Currently, two forms of specific immunotherapy are used clinically in the U.S. The U.S. Food and Drug Administration (FDA) has approved the use of allergen extracts for subcutaneous administration (subcutaneous immunotherapy) for the treatment of seasonal and perennial allergic rhinitis and allergic asthma. In the U.S., a patient with allergies receives subcutaneous injections of an allergen-containing extract, comprised of the relevant allergens to which the patient is sensitive, in increasing doses, in an attempt to suppress or eliminate allergic symptomatology. Considerable interest has also evolved in using sublingual immunotherapy as an alternative to subcutaneous injection immunotherapy. Sublingual immunotherapy involves placement of the allergen under the tongue for local absorption to desensitize the allergic individual over a period of months to years and diminish allergic symptoms. In 1996, an Immunotherapy Task Force, assembled by the World Allergy Organization, cited the emerging clinical data on sublingual immunotherapy, recognized its potential as a viable alternative to subcutaneous therapy, and encouraged continued clinical investigation to characterize optimal techniques. Over the past two decades, sublingual forms of immunotherapy have gained favor in Europe; sublingual tablet immunotherapy has been approved by the European regulatory authorities. In the U.S., there are currently no FDA-approved sublingual forms of immunotherapy. In the absence of FDA-approved sublingual forms of immunotherapy, some researchers and physicians in the U.S. are exploring the off-label use of subcutaneous aqueous allergens for sublingual desensitization. An increasing number of U.S. physicians are employing this alternate desensitization approach in the treatment of allergic respiratory conditions based on European and U.S. studies, and on the European Medicines Agency's approval of certain oral products; however, due to differing standardization of potency in Europe and the United States, doses have been hard to translate between countries. The primary objective of this comparative effectiveness review is to evaluate the efficacy, effectiveness, and safety of SIT (including both subcutaneous and sublingual immunotherapy) that are presently available for use by clinicians and patients in the U.S. We addressed the following Key Questions (KQs): KQ1. What is the evidence for the efficacy and effectiveness of SIT in the treatment of allergic rhinoconjunctivitis and/or asthma? KQ2. What is the evidence for safety of SIT in patients with allergic rhinoconjunctivitis and/or asthma? KQ3. Is the safety and effectiveness of SIT different in distinct subpopulations with allergic rhinoconjunctivitis and/or asthma? Specifically: Children, Adults, Elderly, Pregnant women, Minorities, Inner-city and rural residents, Monosensitized individuals, Patients with severe asthma.
Author: Richard D. Granstein Publisher: S. Karger AG (Switzerland) ISBN: Category : Medical Languages : en Pages : 360
Book Description
Among the topics reviewed are T and B cell tolerance, clonal deletion, suppressor cells, mechanisms of immune privileged sites and experimental models of tumor immunity. Oral tolerance, ultraviolet radiation and photosensitized effects on immunity, allograft management, T cell vaccination and regulation of immunity with T cell epitopes are discussed from the point of view of possible therapeutic application.
Author: Udo R. Markert
Author: Udo R. Markert
Author: Jean Bousquet
Author: Jean Bousquet
Author: Linda S. Coz
Author: Taylor & Francis Group
Author: Gaetano Melillo
Author: Kari Nadeau MD, PhD
Author: 
Author: U. S. Department of Health and Human Services
Author: Richard D. Granstein