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Author: Wan-Liang Lu Publisher: Springer ISBN: 9783662493182 Category : Technology & Engineering Languages : en Pages : 0
Book Description
This volume describes the protocols for fabrication of liposomal drug delivery system, and consists of two parts. The first part emphasizes the basic protocols and concepts for fabrication of drug-loaded liposomes. For new investigators, laying the groundwork is the first step. This part focuses on the fabrication details in liposomes formulations, which are the so-called small tricks while usually not disclosed in mostly published research articles. However, these processing details are crucial for the preparation of liposomes. And the second part focuses on the strategies in modified and/or functionalized liposomes to adapt to pathophysiological environment, as well as their application in treating diseases. As new analytical and synthetic technologies become available, and improved understanding of pathophysiology, various functionalized drug liposomes are developing to fit the requirements of different therapeutic purposes, exhibiting a broad range of applications. Accordingly, the objectives of this part are aimed at deeply unearthing the formulation of drug-loaded liposomes, describing the detailed operation of liposomal formulation, and further demonstrating their potential applications. Therefore, this volume shows the features of experimental report or protocol for proving a guide to scientists, research students, and young investigators in pharmaceutical enterprises.
Author: Wan-Liang Lu Publisher: Springer ISBN: 9783662493182 Category : Technology & Engineering Languages : en Pages : 0
Book Description
This volume describes the protocols for fabrication of liposomal drug delivery system, and consists of two parts. The first part emphasizes the basic protocols and concepts for fabrication of drug-loaded liposomes. For new investigators, laying the groundwork is the first step. This part focuses on the fabrication details in liposomes formulations, which are the so-called small tricks while usually not disclosed in mostly published research articles. However, these processing details are crucial for the preparation of liposomes. And the second part focuses on the strategies in modified and/or functionalized liposomes to adapt to pathophysiological environment, as well as their application in treating diseases. As new analytical and synthetic technologies become available, and improved understanding of pathophysiology, various functionalized drug liposomes are developing to fit the requirements of different therapeutic purposes, exhibiting a broad range of applications. Accordingly, the objectives of this part are aimed at deeply unearthing the formulation of drug-loaded liposomes, describing the detailed operation of liposomal formulation, and further demonstrating their potential applications. Therefore, this volume shows the features of experimental report or protocol for proving a guide to scientists, research students, and young investigators in pharmaceutical enterprises.
Author: Madhumati Bhaskarwar Publisher: Momentum Press ISBN: 1944749284 Category : Technology & Engineering Languages : en Pages : 164
Book Description
This book throws light on the various methods of preparation and characterization of liposomes. With the advancements in technology since their discovery, newer methods of generating liposomes have been developed. Needless to say, over time liposomes have been modified to a large extent and engineered to suit many of our growing needs. This book throws light on the various methods of preparation and characterization of liposomes. It also discusses the several biochemical and indirect methods that have made it possible to understand the biological and physicochemical mechanisms of liposomes that decide their fate in vivo. In spite of certain limitations, liposomes have proved to be more suitable for a number of unconventional applications. This versatility of liposomes outlined in the book brings out the importance of these nanoparticles in the future applications of nanotechnology besides targeted drug delivery. Overall, this book provides the necessary information about the various aspects of liposomes for beginners.
Author: Danilo D. Lasic Publisher: CRC Press ISBN: 1351414011 Category : Medical Languages : en Pages : 324
Book Description
This book examines stealth liposomes from a multidisciplinary approach, which includes theoretical polymer physics, organic synthesis, colloid science, and biology. Discussions include theory, chemistry, biochemistry, pharmacology, preclinical studies in model systems, and medical applications in humans.
Author: Gianni Ciofani Publisher: Elsevier ISBN: 0128141573 Category : Technology & Engineering Languages : en Pages : 270
Book Description
Smart Nanoparticles for Biomedicine explores smart nanoparticles that change their structural or functional properties in response to specific external stimuli (electric or magnetic fields, electromagnetic radiation, ultrasound, etc.). Particular attention is given to multifunctional nanostructured materials that are pharmacologically active and that can be actuated by virtue of their magnetic, dielectric, optically-active, redox-active, or piezoelectric properties. This important reference resource will be of great value to readers who want to learn more on how smart nanoparticles can be used to create more effective treatment solutions. Nanotechnology has enabled unprecedented control of the interactions between materials and biological entities, from the microscale, to the molecular level. Nanosurfaces and nanostructures have been used to mimic or interact with biological microenvironments, to support specific biological functions, such as cell adhesion, mobility and differentiation, and in tissue healing. Recently, a new paradigm has been proposed for nanomedicine to exploit the intrinsic properties of nanomaterials as active devices rather than as passive structural units or carriers for medications. - Discusses the synthesis, characterization and applications of a new generation of smart nanoparticles for nanomedicine applications - Explores the problems relating to the biocompatibility of a range of nanoparticles, outlining potential solutions - Describes techniques for manipulating specific classes of nanoparticles for a variety of treatment types
Author: Vivek Dave Publisher: John Wiley & Sons ISBN: 1119711681 Category : Computers Languages : en Pages : 467
Book Description
The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.
Author: Jin-Chul Kim Publisher: Springer Nature ISBN: 3030842622 Category : Medical Languages : en Pages : 603
Book Description
With the start of 2020, the wrath of pandemic challenged the scientific community to develop more advanced drug delivery approaches for biomedical applications, endowing conventional drugs with additional therapeutic benefits and minimum side effects. Although significant advancements have been done in the field of drug delivery, there is a need to focus towards strategizing novel and improved drug delivery systems that should be convenient and cost-effective to the patients, and simultaneously they should also provide financial benefits to pharmaceutical companies. Controlled drug delivery technology offers ample opportunities and scope for improvising the therapeutic efficacy of drugs via optimizing the drug release rate and time. For this endeavour, smart nanomaterials have served as remarkable candidates for biomedical applications, owing to their ground-breaking properties and design. The development of such nanomaterials requires a broad knowledge related to their physio-chemical properties, molecular structure, mechanisms by which the nanomaterials interact with the cells, and methods by which drugs are released at the site of action. This knowledge must also be allied with the knowledge of signaling crosstalk mechanisms that are modulated by the nanomaterial-drugs composite. It can be anticipated that these emerging drug delivery technologies can facilitate the world to successfully encounter such pandemic outbursts in the future in a cost-effective and time-effective manner. The chapters in this book deal with the advanced technologies and approaches that can benefit advanced students, researchers, and industry experts in developing smart and intelligent nanomaterials for future biomedical applications, and development, manufacturing, and commercialization for controlled and targeted drug delivery.
Author: Angel Catala Publisher: BoD – Books on Demand ISBN: 1789844940 Category : Science Languages : en Pages : 104
Book Description
Liposomes have received increased attention in recent years. Nevertheless, liposomes, due to their various forms and applications, require further investigation. These structures can deliver both hydrophilic and hydrophobic drugs. The preparation of liposomes results in different properties for these systems. In addition, there are many factors and difficulties that affect the development of liposome drug delivery structures.The purpose of this book is to concentrate on recent developments in liposomes. The articles collected in this book are contributions by invited researchers with long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, not only scientists but also people with a general background in many different biological sciences. This volume offers up-to-date, expert reviews of the fast-moving field of liposomes and is divided in two major sections: 1. Introduction; 2. Liposomes general properties
Author: Alexandru Grumezescu Publisher: William Andrew ISBN: 0323428916 Category : Technology & Engineering Languages : en Pages : 461
Book Description
Nanobiomaterials in Galenic Formulations and Cosmetics: Applications of Nanobiomaterials is one of the first books on the market related to the application of nanotechnology in galenic formulations and cosmetics. This book provides the results of current research for those working in an applied setting. The advantage of having all this information in one coherent text is the focused nature of the chapters and the ease of which this information can be accessed. This collection of titles brings together many of the novel applications these materials have in biology, and discusses the advantages and disadvantages of each application and the perspectives of the technologies based on these findings. At the moment there is no other comparable book series covering all the subjects approached in this set of titles. - Offers an updated and highly structured reference material for students, researchers, and practitioners working in biomedical, biotechnological, and engineering fields - Serves as a valuable resource of recent scientific progress, along with most known applications of nanomaterials in the biomedical field - Features novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology
Author: Margareta Hammarlund-Udenaes Publisher: Springer Science & Business Media ISBN: 1461491053 Category : Medical Languages : en Pages : 737
Book Description
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.
Author: Wan-Liang Lu
Author: Wan-Liang Lu
Author: AlexanderT. Florence
Author: Madhumati Bhaskarwar
Author: Danilo D. Lasic
Author: Gianni Ciofani
Author: Vivek Dave
Author: Jin-Chul Kim
Author: Angel Catala
Author: Alexandru Grumezescu
Author: Margareta Hammarlund-Udenaes