Handbook of Modern Coating Technologies PDF Download

Author: Mahmood Aliofkhazraei
Publisher: Elsevier
ISBN: 0444632468
Category : Science
Languages : en
Pages : 555

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Book Description
Handbook of Modern Coating Technologies: Fabrication Methods and Functional Properties reviews different fabrication methods and functional properties of modern coating technologies. The topics in this volume consist of nanocoatings by sol–gel processes for functionalization of polymer surfaces and textiles and mechanical fabrication methods of nanostructured surfaces such surface mechanical attrition treatment, polymer nanofabrications and its plasma processing, chemical vapor deposition of oxide materials at atmospheric pressure, conventional chemical vapor deposition process at atmospheric pressure, feasibility of atmospheric pressure, chemical vapor deposition process, Langmuir–Blodgett technique, flame pyrolysis, confined-plume chemical deposition, electrophoretic deposition, in vitro and in vivo particle coating for oral targeting and drug delivery, novel coatings to improve the performance of multilayer biopolymeric films for food packaging, corrosion protection by nanostructured coatings, tribological behavior of electroless coatings, effect of peening-based processes on tribological and mechanical behavior of bioimplant materials, improved efficiency of ceramic cutting tools in machining hardened steel with nanostructured multilayered coatings, incorporation of elastomeric secondary phase into epoxy matrix influences mechanical properties of epoxy coatings, enhancement of biocompatibility by coatings, porous hydroxyapatite–based coatings, and bionic colloidal crystal coatings.

Author: Raj K. Arya
Publisher: John Wiley & Sons
ISBN: 1394207271
Category : Technology & Engineering
Languages : en
Pages : 628

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Book Description
FUNCTIONAL COATINGS A must-own resource for understanding functional coatings and their revolutionary potential Functional coatings are those which provide not only the protection and performance enhancement of a conventional coating, but also offer additional properties tailored to meet the specific requirements of a given industry or application. They have applications in a huge range of sectors, including automotive, aerospace, healthcare, energy, and more. Coatings with properties like fire retardancy, antimicrobial properties, or controlled drug release have the potential to revolutionize entire industries. Functional Coatings offers a comprehensive resource for engineers and researchers looking to understand these coatings and the opportunities they provide. Beginning with an overview of the subject’s foundations and industrial significance, the book analyzes numerous coating methods and their properties, with a particular focus on anticorrosion coatings. The result is an indispensable resource for professionals in virtually any technological industry looking to understand the benefits of a cutting-edge toolkit. Functional Coatings readers will also find: Coverage of synthesis, durability, reproducibility, cost-effectiveness, specialized surface morphology, and environmental friendliness of each coating Detailed discussion of antimicrobial coatings, fire-retardant coatings, self-healing coatings, nanopowder coatings, coatings for marine applications, and many more Applications of additives, machine learning, and sophisticated characterizations, etc. as per industry requirements Functional Coatings is ideal for researchers, engineers, and industry professionals working with any area of technology where coatings have purchase.

Author: Geoffrey D Tovey
Publisher: Royal Society of Chemistry
ISBN: 1849739412
Category : Medical
Languages : en
Pages : 432

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Book Description
Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety and stability of the final medicinal product. Modern formulation science deals with biologics as well as small molecules. Regulatory and quality demands, in addition to advances in processing technologies, result in growing challenges as well as possibilities for the field. Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry. The book provides an understanding of the links between formulation theory and the practicalities of processing in a commercial environment, giving researchers the knowledge to produce effective pharmaceutical products that can be approved and manufactured. The first chapters introduce readers to different dosage forms, including oral liquid products, topical products and solid dosage forms such as tablets and capsules. Subsequent chapters cover pharmaceutical coatings, controlled release drug delivery and dosage forms designed specifically for paediatric and geriatric patients. The final chapter provides an introduction to the vital role intellectual property plays in drug development. Covering modern processing methods and recent changes in the regulatory and quality demands of the industry, Pharmaceutical Formulation is an essential, up to date resource for students and researchers working in academia and in the pharmaceutical industry.

Author: Van Trung Tin Huynh
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
Hot-melt coating by fluidised bed consists of delivering molten lipids onto surface of substrate particles in suspension and let them solidify with air-cooling. The process is evidently solventless and therefore time-, cost-efficient and eco-friendly. Lipids constitute a generally-regarded-as-safe class of excipients. Despite those advantages, challenges reside in the fact that their physicochemical and biopharmaceutical properties have not been thoroughly investigated. This thesis dealt with these challenges by considering manufacturability, product stability and release properties. In the first phase “formulation development”, a simple and nimble experimental approach was developed for process and product characterisation in early stage. NaCl, as active substance, allows for fast-track research conduct. With their diverse properties (e.g. complex-mixture vs. pure substance, polymorphism and crystallisation, adaptability to different processing approaches), beeswax, tristearin and trilaurin were chosen as coating materials under research. Additive addition was indispensable and additives of different types were tested with those three lipid systems: (I) polysorbates, (II) sorbitans, (III) vitamin E TPGS and (IV) talc. Besides, several physical and in vitro characterisation techniques have been established, for instance, for rapid screening of solid lipid-additive combinations, in situ monitoring of polymorphic transformation and crystal growth, coupling of digestion and release testing in biologically simulated media. In the second phase “pharmaceutical applications”, three beeswax-, tristearin- and trilaurin-based formulations were selected for coating amorphous solid dispersions of praziquantel. The objectives are (i) to study bioaccessibility of the amorphous active substance coated with lipids of varying digestibility and (ii) to investigate long-term stability of these hot-melt coated products. In conclusion, selection of good additives is important for development of solid lipid-based formulated products. In effect, they can improve productivity of coating operations as well as product performance (stability, release profile).

Author: Ajit S Narang
Publisher: Springer
ISBN: 3319202065
Category : Medical
Languages : en
Pages : 700

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Book Description
In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.

Author: Dennis Douroumis
Publisher: John Wiley & Sons
ISBN: 1118307879
Category : Science
Languages : en
Pages : 404

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Book Description
Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.

Author: Maria Pilar Montero Garcia
Publisher: CRC Press
ISBN: 1315356244
Category : Technology & Engineering
Languages : en
Pages : 607

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Book Description
The search for better strategies to preserve foods with minimal changes during processing has been of great interest in recent decades. Traditionally, edible films and coatings have been used as a partial barrier to moisture, oxygen, and carbon dioxide through selective permeability to gases, as well as improving mechanical handling properties. The advances in this area have been breathtaking, and in fact their implementation in the industry is already a reality. Even so, there are still new developments in various fields and from various perspectives worth reporting. Edible Films and Coatings: Fundamentals and Applications discusses the newest generation of edible films and coatings that are being especially designed to allow the incorporation and/or controlled release of specific additives by means of nanoencapsulation, layer-by-layer assembly, and other promising technologies. Covering the latest novelties in research conducted in the field of edible packaging, it considers state-of-the-art innovations in coatings and films; novel applications, particularly in the design of gourmet foods; new advances in the incorporation of bioactive compounds; and potential applications in agronomy, an as yet little explored area, which could provide considerable advances in the preservation and quality of foods in the field.

Author: Edmund S. Kostewicz
Publisher: John Wiley & Sons
ISBN: 1119772710
Category : Medical
Languages : en
Pages : 516

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Book Description
ORAL DRUG DELIVERY FOR MODIFIED RELEASE FORMULATIONS Provides pharmaceutical development scientists with a detailed reference guide for the development of MR formulations Oral Drug Delivery for Modified Release Formulations is an up-to-date review of the key aspects of oral absorption from modified-release (MR) dosage forms. This edited volume provides in-depth coverage of the physiological factors that influence drug release and of the design and evaluation of MR formulations. Divided into three sections, the book begins by describing the gastrointestinal tract (GIT) and detailing the conditions and absorption processes occurring in the GIT that determine a formulation’s oral bioavailability. The second section explores the design of modified release formulations, covering early drug substance testing, the biopharmaceutics classification system, an array of formulation technologies that can be used for MR dosage forms, and more. The final section focuses on in vitro, in silico, and in vivo evaluation and regulatory considerations for MR formulations. Topics include biorelevant dissolution testing, preclinical evaluation, and physiologically-based pharmacokinetic modelling (PBPK) of in vivo behaviour. Featuring contributions from leading researchers with expertise in the different aspects of MR formulations, this volume: Provides authoritative coverage of physiology, physicochemical determinants, and in-vitro in-vivo correlation (IVIVC) Explains the different types of MR formulations and defines the key terms used in the field Discusses the present status of MR technologies and identifies current gaps in research Includes a summary of regulatory guidelines from both the US and the EU Shares industrial experiences and perspectives on the evaluation of MR dosage formulations Oral Drug Delivery for Modified Release Formulations is an invaluable reference and guide for researchers, industrial scientists, and graduate students in general areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Author: Michael A. Repka
Publisher: Springer Science & Business Media
ISBN: 1461484324
Category : Medical
Languages : en
Pages : 472

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Book Description
This volume provides readers with the basic principles and fundamentals of extrusion technology and a detailed description of the practical applications of a variety of extrusion processes, including various pharma grade extruders. In addition, the downstream production of films, pellets and tablets, for example, for oral and other delivery routes, are presented and discussed utilizing melt extrusion. This book is the first of its kind that discusses extensively the well-developed science of extrusion technology as applied to pharmaceutical drug product development and manufacturing. By covering a wide range of relevant topics, the text brings together all technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements. As extrusion technology continues to be refined further, usage of extruder systems and the array of applications will continue to expand, but the core technologies will remain the same.

Author: Sougata Jana
Publisher: Springer
ISBN: 9811036470
Category : Medical
Languages : en
Pages : 457

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Book Description
The book focuses on novel particulate technologies for the purpose of drug delivery to humans. Nowadays, macro and nano-scale particles are being investigated for targeted delivery of small and large biological macromolecules. The targeting of drugs can minimize the dosage regimen and reduces dose related potential toxicity of drug molecules, which in turn lead to increased potential compliance. Various types of organic, inorganic and polymer particles are currently being investigated. These are attracting the attention of the research workers in the field of drug delivery science and technology. This book covers polymersomes, inorganic- organic composites, gold nanoparticles biopolymer and synthetic polymer particles etc.All aspects of drug delivery in relation to each technology have been described including these advances, Easy to read and understand the content of each chapter Rich in up-to-date information regarding their application.