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Author: Hans-Joachim Gabius Publisher: Springer Science & Business Media ISBN: 3642736629 Category : Medical Languages : en Pages : 226
Book Description
Cellular glycoconjugates and their specific receptors, e.g. lectins, form a recognitive and informative transfer system that justifies special scientific and clinical attention. In various contributions reviewing the initiation and recent progress in this rapidly developing field advances in clinical oncology are discussed with regard to basic sciences as well as their application in clinical sciences. The approaches comprise reports from diverse fields such as biochemistry, cell biology, pathology and clinical oncology, addressing questions of how tumors grow and spread, and leading to the improvement of clinical management and tumor diagnosis.
Author: Hans-Joachim Gabius Publisher: Springer Science & Business Media ISBN: 3642736629 Category : Medical Languages : en Pages : 226
Book Description
Cellular glycoconjugates and their specific receptors, e.g. lectins, form a recognitive and informative transfer system that justifies special scientific and clinical attention. In various contributions reviewing the initiation and recent progress in this rapidly developing field advances in clinical oncology are discussed with regard to basic sciences as well as their application in clinical sciences. The approaches comprise reports from diverse fields such as biochemistry, cell biology, pathology and clinical oncology, addressing questions of how tumors grow and spread, and leading to the improvement of clinical management and tumor diagnosis.
Author: Hans-Joachim Gabius Publisher: Springer Science & Business Media ISBN: 3642767397 Category : Medical Languages : en Pages : 332
Book Description
Molecular recognition undoubtedly governs any aspect of cellular interaction. To understand tumor cell growth regulation and spread, analysisof protein carbohydrate interactions can contribute to lead to the establishment of rational methods for diagnosis and therapy. Chemically and biochemically optimized preparation of adequate tools, their application for localization of receptor (tissue lectin) and ligand (cellular glycoconjugate) pairs in tumor cells and tumor sections and the usefulness of a lectin from a plant extract as potent immunomodulator indicate the prospect for a place of such techniques in pathology and oncology.
Author: Hans-Joachim Gabius Publisher: John Wiley & Sons ISBN: 3527614729 Category : Science Languages : en Pages : 663
Book Description
A comprehensive survey of the topic, ranging from basic molecular research to clinical applications. Critical reviews by leading experts in each field summarize the state of knowledge and discuss the anticipated benefits of novel approaches and strategies. These include the impact of modern analysis techniques on glycobiology, the use of synthetic neoglycoproteins, or the clinical consequences of new insights into the physiological role of lectins and glycoconjugates in pathology, oncology, immunity, neuroscience and reproduction medicine. Throughout, the aim is to separate realistic applications from mere hopes.
Author: Hans-Joachim Gabius Publisher: ISBN: Category : Glycoconjugates Languages : en Pages : 552
Book Description
The intriguing complexity, precision, and regulation of the wide range of biologi cal processes is determined by intricate mechanisms of molecular recognition. Their nature is under intense scrutiny. In addition to the well-appreciated interac tion of proteins either with amino acid or nucleotide sequences, the investigation of their interplay with carbohydrate elements of cellular glycoconjugates current ly exerts increasing attraction. In the group of carbohydrate-binding proteins, lec tins are distinguished from antibodies or ligand-affecting enzymes, according to the most recent definition. The thorough analysis of their structure and function is considered as a focus to collect a critical mass of information for delineating details of a further array of biochemical processes with pivotal physiological im pact. Following an already century-long history of scientific description, reflected by subjectively chosen highlights (see the Brief History of Lectin Research at page VI), the excitement in glycobiological research that prevails today can easily be ex plained by our growing awareness of the multifarious significance of a sugar-code system of biological information. This present notion unmistakably has an im pact on lines of research in diverse disciplines like cell and molecular biology, histochemistry, or clinical sciences. It also prompts inherent practical questions such as how to obtain lectins, or how to employ them as instruments in various assay systems with the best possible results. Thus, this book is devoted intentionally to cover the techniques in different research fields that deal with lectins.
Author: A. Pusztai Publisher: Cambridge University Press ISBN: 0521328241 Category : Medical Languages : en Pages : 276
Book Description
This volume surveys the chemistry, biochemistry, biosynthesis, metabolism and pharmacological properties of lectins. Lectins, which are most commonly found in plants, are widespread natural products with striking biological activities. Their specific ability to recognise and bind to simple or complex saccharides facilitates their role as effective information protein molecules. As agents of cell-to-cell recognition, lectins promote symbiosis between plants and specific nitrogen-fixing soil bacteria. As natural defensive molecules, they can protect plants against predators such as bacteria, fungi and insects. As part of our diet, lectins are powerful exogenous growth factors in the small intestine and influence our health, the digestive function and the bacterial ecology of the alimentary tract. Lectins are also important research tools in preparative biochemistry and cell science.
Author: Publisher: ISBN: Category : Languages : en Pages :
Book Description
Abstract : Lectins are carbohydrate or glycan binding proteins produced by every living species. Binding of lectins to glycan epitopes of glycoproteins is essential for initiating a variety of biological functions. Galectin-3 (Gal-3) is an endogenous human lectin that plays important roles in cell proliferation, adhesion, differentiation, metastasis, angiogenesis, and apoptosis. This dissertation describes two new binding properties of Gal-3 that are physiologically relevant. The new interaction of Gal-3 described herein significantly extends its biological function. Biological interactions of Gal-3 are known to occur when it binds to glycoproteins. However, we found that Gal-3 also binds to another class of glycoconjugates, namely, proteoglycans and their constituent glycosaminoglycans. Calorimetric data show that Gal-3 binds with glycosaminoglycans (heparin and chondroitin sulfate) and chondroitin sulfate proteoglycans (CSGPs). Spectroscopic data reveal that Gal-3 cross-links with chondroitin sulfate A and C as well as a CSGP and forms insoluble complexes. Such cross-linking of Gal-3 by glycosaminoglycans is potentially important for many biological processes including cell-signaling. We also discovered that Gal-3, produced by malignant thyroid gland, interacts with a thyroid cancer biomarker, thyroglobulin (Tg) with nanomolar affinity. This interaction can interfere with the clinical detection of thyroid cancer and can also impact thyroid hormone production and immune response. To produce sufficient Gal-3 for these studies, a new purification protocol named 'Capture and Release' (CARE) was developed. This protocol is cost-effective, faster and was found to be efficient enough to purify other lectins besides Gal-3. The function of lectins including Gal-3, depends on the interaction with their binding partners (glycoconjugates). Glycoconjugate is a common name of any macromolecule that contains glycans linked to a protein or lipid core (scaffold). The outcome of lectin-glycoconjugate interactions is believed to depend solely on the structures of the lectin and the glycan epitopes. However, we discovered that the scaffold part plays a vital role in the binding process. This dissertation thus describes a novel molecular mechanism associated with glycoconjugate functions and new physiologically-relevant recognition properties of an important human lectin (Gal-3).
Author: Evandro Fei Fang Publisher: Springer ISBN: 9789401785297 Category : Medical Languages : en Pages : 0
Book Description
The modern unhealthy diet and lifestyle in conjunction with pathogens, environmental carcinogens and multiple other risk factors increase humans’ susceptibility to different diseases exemplified by elevated levels of cancers, cardiovascular and communicable diseases. Screening of potential drugs from medicinal plants and animals provides a promising strategy for the alleviation of the impact of these diseases. Components with potential medicinal applications include RIPs, RNases, lectins, protease inhibitors and numerous small compounds. These compounds have shown both preventive and therapeutic effects for humans. This book is a compilation of articles written by internationally renowned experts exploring the different uses of medicinal compounds in human therapeutics. Here we provide a comprehensive outlook on both qualitative and quantitative studies focusing on medicinal plants and animals, and establishing a link between laboratory research discovery and clinical applications.
Author: Harmin Herrera Publisher: ISBN: Category : Biochemical markers Languages : en Pages : 241
Book Description
Changes in serum glycosylation have long been associated with hepatocellular carcinoma (HCC), and these modifications are often detected with sugar-binding proteins called lectins. HCC is associated with increased serum fucosylation, and this sugar is often detected with the Aleuria aurantia lectin (AAL). However, this lectin binds fucose in several forms, one of which is associated with cancer ([alpha]1-6 linked fucosylation) and some of which are not. Thus, its use in clinical and tissue analysis is limited. We have created a recombinant AAL, which contains a single amino acid mutation: N224Q (rAALN224Q), within the binding site 5, and this lectin has increased sensitivity to the cancer-specific fucosylated glycan. Our analysis of rAALN224Q has shown that the mutation within one specific fucose binding pocket had a major impact upon the mutated site as well as on sites that were not mutated and led to a lectin with altered binding specificities. This lectin is currently part of a diagnostic test under evaluation for the early detection of HCC. We have further explored the changes in N-linked glycosylation associated directly with HCC tissue through a method of N-linked glycan matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS). MALDI IMS of N-linked glycan revealed inter- and intra-tumor heterogeneity shown by expression and spatial localization of glycans in the tumor. Tumors were associated with alterations in mannosylation, fucosylation, branching, and complex glycan formation. Importantly, all tumors were associated with some change in glycosylation, but there was significant glycan heterogeneity.
Author: Albert M. Wu Publisher: Springer ISBN: 9781461354697 Category : Science Languages : en Pages : 640
Book Description
I organized this symposium, "Molecular Immunology of Complex Carbohydrates-2 (MICC-2)," at the Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan th between August 28-September 2, 1999, as a satellite meeting of the 15 International Glycoconjugate Conference (held August 22-27 in Tokyo, Japan). I also held a Taiwan Canada Glycobiology Workshop after this meeting at the Institutes of Biological Chemistry and Chemistry. To promote glycobiology in Taiwan, I offered a Complexs Carbohydrate & Medicine-2 workshop at the Glyco- Research Laboratory, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan before the MICC-2 symposium. The lecture and poster materials of these three meetings are collected in these proceedings, which are divided into five Sections and two Appendixes. Section I, entitled "Protein-Carbohydrate Interactions of Plant and Animal Lectins," provides current concepts of lectin-carbohydrate interactions; classification of lectins, based on amino acid sequences, molecular structures, and lectin affinity for carbohydrates. However, the relationships between amino acid sequences and carbohydrate affinity of lectins have to be more thoroughly characterized. The reviews on animal lectins in this Section explore new areas of lectins. Section II, "Aspects of Structure and Antigenicity of Glycoconjugates," provides important information on structural concepts of glyco immunology. "Glycotope Expression (Glycosylation), Metabolism and Functions," which play important roles in life processes, are discussed in Section III. Four articles on advances in knowledge on structural roles of glycans and treatment of cancer are discussed in Section IV.
Author: Hans-Joachim Gabius
Author: Hans-Joachim Gabius
Author: Hans-Joachim Gabius
Author: Hans-Joachim Gabius
Author: Hans-Joachim Gabius
Author: Hans-Joachim Gabius
Author: A. Pusztai
Author: 
Author: Evandro Fei Fang
Author: Harmin Herrera
Author: Albert M. Wu