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Author: Daniel Robert Lykins Publisher: ISBN: 9781423523413 Category : Laser pulses, Ultrashort Languages : en Pages : 104
Book Description
The use of laser light for targeting devices and industry has dramatically increased the likelihood that personnel will be exposed to laser energy during military and commercial operations. The increased potential for exposure of humans to lasers highlights the need to understand laser-tissue interactions at the most basic cell and molecular levels. Current ultrashort pulse laser safety standards are based on a minimal visible lesion (MVL), i.e., histological, damage endpoint in the Rhesus monkey model (Shaver, 2001). A human model for assessing laser-light damage to tissue at the cell and molecular level is desirable for scientific, political and fiduciary reasons. This research assesses the effects of sublethal pulsed laser-light treatment to a human melanocyte (skin) cell line. Proteomic inquiry into the cellular effect of laser treatment was accomplished via parallel sample analysis with over 850 monoclonal antibodies in order to screen for changes in the levels of protein expression. In short, the data indicated dramatically increased molecular debridement, decreased apoptotic signaling and cell cycling and other cellular phenomena sufficient to propose a stress response and recovery paradigm.
Author: Daniel Robert Lykins Publisher: ISBN: 9781423523413 Category : Laser pulses, Ultrashort Languages : en Pages : 104
Book Description
The use of laser light for targeting devices and industry has dramatically increased the likelihood that personnel will be exposed to laser energy during military and commercial operations. The increased potential for exposure of humans to lasers highlights the need to understand laser-tissue interactions at the most basic cell and molecular levels. Current ultrashort pulse laser safety standards are based on a minimal visible lesion (MVL), i.e., histological, damage endpoint in the Rhesus monkey model (Shaver, 2001). A human model for assessing laser-light damage to tissue at the cell and molecular level is desirable for scientific, political and fiduciary reasons. This research assesses the effects of sublethal pulsed laser-light treatment to a human melanocyte (skin) cell line. Proteomic inquiry into the cellular effect of laser treatment was accomplished via parallel sample analysis with over 850 monoclonal antibodies in order to screen for changes in the levels of protein expression. In short, the data indicated dramatically increased molecular debridement, decreased apoptotic signaling and cell cycling and other cellular phenomena sufficient to propose a stress response and recovery paradigm.
Author: Daniel Robert Lykins Publisher: ISBN: Category : Laser pulses, Ultrashort Languages : en Pages : 104
Book Description
The use of laser light for targeting devices and industry has dramatically increased the likelihood that personnel will be exposed to laser energy during military and commercial operations. The increased potential for exposure of humans to lasers highlights the need to understand laser-tissue interactions at the most basic cell and molecular levels. Current ultrashort pulse laser safety standards are based on a minimal visible lesion (MVL), i.e., histological, damage endpoint in the Rhesus monkey model (Shaver, 2001). A human model for assessing laser-light damage to tissue at the cell and molecular level is desirable for scientific, political and fiduciary reasons. This research assesses the effects of sublethal pulsed laser-light treatment to a human melanocyte (skin) cell line. Proteomic inquiry into the cellular effect of laser treatment was accomplished via parallel sample analysis with over 850 monoclonal antibodies in order to screen for changes in the levels of protein expression. In short, the data indicated dramatically increased molecular debridement, decreased apoptotic signaling and cell cycling and other cellular phenomena sufficient to propose a stress response and recovery paradigm.
Author: Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
The use of laser light for targeting devices and weapons has sharply increased the likelihood that aircrew and support personnel will be exposed to laser light during operations. The increased potential for exposure of humans highlights the fact that there is a need for scientifically based safety standards for laser exposure at the ultrashort pulse lengths. Current safety standards are largely extrapolations of exposure limits at longer pulse lengths using a minimal visible lesion endpoint in the Rhesus monkey retinal model. A non-animal model for assessing laser-light damage to tissue, particularly human, is quite desirous for obvious scientific, political, and fiduciary reasons. I assessed the sublethal insult to human cells using a tissue culture system for specific genes that have been shown to be important in several biological processes that could lead to cancer or cell death. Using the CAT-Tox (L) (xenometrix, Inc.) assay, it appears that 532 nm nanosecond pulse of laser light are sensed and induces several stress response genes including FOS in a roughly dose dependent fashion. This approach provides insight into a more global methodology for characterizing environmental stressors via genetic profiling.
Author: John W. Obringer Publisher: ISBN: Category : Cell physiology Languages : en Pages : 25
Book Description
The use of laser light for military and commercial applications has sharply increased the likelihood of personnel exposure to laser light during operations. The increased potential for human exposure highlights the fact that there is paucity of basic science at the cell and molecular level concerning the effects of laser exposure of human cells. As a research demonstration of technology we assessed the sublethal insult to human retinal pigment epithelial cells using a human retinal pigment epithelial explant system for glycan-protein binding patterns differentially expressed 12 hours post-exposure using glycan-protein binding microarray technology (GlycoChip Array, Glycominds Ltd.). It is evident that pulses of laser light are sensed and markedly alter glycan-protein binding patterns. The nanosecond pulses of 532 nm light (107mJ/cm2) appeared to increase the labeled protein binding in two-thirds of the probed glycans in the treated tissue. As expected, some binding increased, while others decreased and some remained unchanged. This report constitutes the first ever investigation into laser-light alteration of protein-glycan interactions which may have major implications in the post irradiation response of the tissue involved given the biological relevance of glycans and their protein interactions. This investigative approach also showcases a global methodology for characterizing environmental stressors on life.
Author: D.R. Vij Publisher: Springer Science & Business Media ISBN: 1461509297 Category : Technology & Engineering Languages : en Pages : 381
Book Description
A careful review of the literature covering various aspects of applications of lasers in science and technology reveals that lasers are being applied very widely throughout the entire gamut of physical medicine. After surveying the current developments taking place in the field of medical applications of lasers, it was considered appropriate to bring together these efforts of international research scientists and experts into one volume. It is with this aim that the editors have prepared this volume which brings current research and recent developments to the attention of a wide spectrum of readership associated with hospitals, medical institutions and universities world wide, including also the medical instrument industry. Both teachers and students in the medical faculties will especially find this compendium quite useful. This book is comprised of eleven chapters. All of the important medical applications of lasers are featured. The editors have made every effort that individual chapters are self-contained and written by experts. Emphasis has been placed on straight and simple presentation of the subject matter so that even the new entrants into the field will find the book of value.
Author: Gregory T. Absten Publisher: Springer ISBN: 9780412266508 Category : Biomedical engineering Languages : en Pages : 63
Book Description
Lasers were developed out of Einstein's theories, but the first work ing device was not produced until 1960. Since then, they have found applications in many areas of medicine, and hold promise for many more. This book has been written to provide a basic found ation on lasers - what they are, how they work, and what they can do for the patient. It assumes only a basic scientific background in the reader, and has many simple and clear diagrams. It should be of interest to clinicians, surgeons, nurses, safety officers, patients and interested laymen. The book consists of six chapters, and following a glossary of technical terms, begins with a brief discussion of the physics behind laser action. This section is illustrated with clear diagrams, and is written in an easy-to-follow style. It describes how laser light originates, and how it differs fundamentally from ordinary light. The remainder of the book is concerned with the use of lasers in medicine. Chapter 2 deals with the various ways in which a laser beam can interact with tissue, and shows how this depends on the particular laser being used. The following chapter describes some properties of those lasers which are most usually used in current medical practice, but also discusses new and experimental develop ments. There are various methods of getting the laser beam to the target tissue, and these are described in Chapter 4.
Author: Chris Sutton Publisher: John Wiley & Sons ISBN: Category : Medical Languages : en Pages : 302
Book Description
This volume features a collection of research papers on laser practice in gynaecology. The contributors discuss basic laser physics, laser-tissue interactions, laser safety, laser surgery of the cervix, endoscopic laser operations and the future of laser surgery.
Author: Giovanni Olivi Publisher: Springer ISBN: 3319193279 Category : Medical Languages : en Pages : 297
Book Description
This book offers up-to-date information on all aspects of the use of lasers in endodontics, focusing especially on the various laser applications, including primary and permanent root canal therapies, retreatments, apical surgery and pulp therapy. Every laser technique used in endodontics is carefully described and illustrated, with detailed coverage of both conventional methods and more recent developments such as laser-activated irrigation and photon-induced photoacoustic streaming. In addition, a separate section addresses the basic science of laser dentistry, explaining the physics, describing laser–tissue interactions, and discussing different types of laser. Extensive reference is made to the international literature in order to provide the reader with a clear, evidence-based understanding of the merits of various approaches. In offering a balanced mix of descriptions of clinical applications, clinical data, scientific research and logical criticism, the book will serve as an excellent reference for a wide audience comprising general dentists as well as specialists.
Author: Daniel Robert Lykins
Author: Daniel Robert Lykins
Author: Daniel Robert Lykins
Author: 
Author: John W. Obringer
Author: D.R. Vij
Author: Arunn V. Holden
Author: 
Author: Gregory T. Absten
Author: Chris Sutton
Author: Giovanni Olivi