Author: Publisher:
ISBN:
Category :
Languages : fr
Pages : 172
Book Description
Thérapie génique
Author: La thérapie génique
Author: Solange LatouretteMechanistic Investigation of Microbubble-mediated Sonoporation for Intracellular Gene Delivery
Author: Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
La clé du succès en thérapie génique est de trouver un bon vecteur et/ou une méthode permettant d'assurer l'efficacité de la transfection et la sécurité du patient. Les travaux de recherches s'orientent actuellement vers une nouvelle approche de la thérapie génique: la sonoporation qui consiste en l'utilisation des ultrasons pour le transfert de gènes. Cette technique a les avantages d'une méthode peu invasive et spécifique, proposant une libération ciblée et contrôlée du gène thérapeutique. De plus, l'utilisation d'agents de contraste ultrasonores (microbulles) permet d'améliorer la transfection et de combiner la thérapie et le diagnostic. La sonoporation est une technique relativement récente. Dans un premier temps, l'étude des mécanismes in vitro, nécessaires au bon développement de cette méthode, a été investiguée. Ensuite, l'importance de la formulation des microbulles a été démontrée. Enfin, les études in vivo ont illustré le potentiel de la sonoporation pour une éventuelle application à l'homme.
Author: Publisher: Odile Jacob
ISBN: 2738180515
Category :
Languages : en
Pages : 353
Book Description
Genetically Modified Organisms and Genetic Engineering in Research and Therapy
Author: Pascale PiguetPublisher: Karger Medical and Scientific Publishers
ISBN: 3805590652
Category : Science
Languages : en
Pages : 138
Book Description
Genetically modified organisms (GMO) raise societal, political and ethical concerns. They inspire strong resistance or, conversely, enthusiastic assent. The aim of this publication is to give an overview of genetic engineering, starting with the history of the discovery of restriction enzymes continuing with technical aspects of transgenesis to its applications in research and ethical considerations. Be it the use of single engineered cells or GMO, these applications cover a broad array, ranging from disease-oriented research (but not only), to the promising perspectives of gene therapy. Historical and technical aspects give insights into the problems inherent to the creation of GMO, and illustrate the links and limits between genetic engineering, GMOs and gene therapy. A summary article in English and French structures the links between the different chapters and concepts. Scientists interested in genetic engineering of single cells or animal models, as well as in gene therapy, will find an up-to-date review on the use and perspectives of transgenesis. However, this publication is also recommended to the public interested in the definition of GMO, which encompasses a much broader array than the genetically modified crops covered by media.
Biomedicine, the Family and Human Rights
Author: Marie-Thérèse Meulders-KleinPublisher: BRILL
ISBN: 9047403037
Category : Law
Languages : en
Pages : 650
Book Description
This volume examines the impact of advances in genetics and assisted reproduction technologies on family law, human rights and the rights of the child, including the effects of international treaties on national legislation. It surveys the theoretical, ethical and legal discussions with regard to biotechnology and family law issues and the search for a balance between safeguarding respect for human rights and fundamental freedoms and the need to ensure freedom of research. However, biotechnology impinges not only on isolated individuals and their rights, but also on unborn children, the family as a network of living relationships and the basic structure of any society, as well as the foundation of parentage and kinship, social organization as a whole and, finally, mankind itself. As the attention of the World turns to cloning, this book will contribute to the search for a balance between the rights and freedoms of born and yet to be born human beings and the quest for new technologies.
Documents
Author: Council of EuropePublisher: Council of Europe
ISBN: 9789287125057
Category : Political Science
Languages : en
Pages : 276
Book Description
Parallel main title: Documents de sâance. Parallel text in English and French
Biomedical Research in the Drugs Field
Author: Richard MuscatPublisher: Council of Europe
ISBN: 9287160171
Category : Science
Languages : en
Pages : 114
Book Description
Why is it that certain people use drugs in the first place and then why do some become dependent following repeated use while others do not? What are the possible implications of the current state of affairs of research from a biomedical or more aptly put, a Neuroscience perspective, including an ethical point of view? These are questions the author attempts to answer as the biomedical or neuroscience research in the drug field is a fast moving area with ethical implications that have arisen as a result of the conduct of such research.
Gene Therapy: Prospective Technology assessment in its societal context
Author: Jörg NiewöhnerPublisher: Elsevier
ISBN: 0080470939
Category : Science
Languages : en
Pages : 275
Book Description
This book presents work that has been conducted as part of the research project "Discourse on ethical questions of biomedicine" of the interdisciplinary Working Group Bioethics and Science Communication at the Max-Delbrueck-Center for Molecular Medicine (MDC)in Berlin-Buch, Germany. This book offers ground-breaking ideas on how the daily interworking of cutting-edge biomedical research assess the broader social context and its communication to stakeholders and the public. Editors cover three aspects: Scientific, Ethical and Legal, and Perception and Communication. This work establishes an international and interdisciplinary network of excellent researchers at the beginning of their careers, who brilliantly integrate their work into the different perspectives on gene therapy from the natural and social sciences, as well as the humanities and law.* Discusses biological and cellular barriers limiting the clinical application of nonviral gene deliverysystems* Addresses such questions as: Does patent granting hinder the development of Gene Therapy products?* Offers insight in the future of public perception of gene therapy in Europe* Provides details on how to communicate risks in gene therapy
The Ongoing Technological System
Author: Smaïl Aït-El-HadjaitPublisher: John Wiley & Sons
ISBN: 1119467055
Category : Technology & Engineering
Languages : en
Pages : 136
Book Description
The high level of innovation currently transforming our society and its technological dynamics can be seen as a second wave of innovation of the third technological system, which emerged in the late 1970s. This book discusses the concept of technological systems, focusing on the tools used for formalizing the organization of technology in society and its dynamics of evolution. The author uses these tools to characterize the contemporary technological system and to model its specific dynamics. In doing so, he raises questions about the continuity of the current technological system, and its capacity to generate powerful innovatory movements.