Author: Laurent GueriniPublisher:
ISBN:
Category :
Languages : fr
Pages : 364
Book Description
La pioglitazone dans le traitement du diabète de type II
Author: Laurent GueriniNouvelles recommandations dans le traitement du diabète de type II
Author: Antoine DarrasConséquences médico-économiques du retrait du marché de la pioglitazone en Franche-Comté
Author: Anne-Sophie GrgicPublisher:
ISBN:
Category :
Languages : fr
Pages : 130
Book Description
La physiopathologie du diabète de type 2 est caractérisée initialement par le développement d'une insulinorésistance, qui constitue la cible thérapeutique des agents antidiabétiques de la classe des thiazolidinediones. La pioglitazone, dernière représentante de cette classe, a été retirée du marché français en 2011. L'objectif de ce travail est d'évaluer les conséquences médico-économiques à un an de ce retrait. Une étude rétrospective, fondée sur les données de remboursements du régime général de l'assurance maladie en Franche Comté, a été réalisée sur un échantillon de 36 254 patients diabétiques. Cette étude n'indique pas d'effet délétère de l'arrêt de la pioglitazone sur la consommation de médicaments, le montant remboursé du traitement et des soins et le taux d'hospitalisation. Cependant, les variations entre les différentes stratégies thérapeutiques (monothérapie, bithérapie,...) peuvent laisser penser que, chez certains patients, la pioglitazone n'a pas été remplacée, ce qui peut induire un déséquilibre de leur diabète. En cas de substitution de la pioglitazone, les prescripteurs se sont préférentiellement orientés vers les médicaments de la classe des inhibiteurs de la DPP-4, les insulinosécréteurs et l'insuline. Une étude réalisée sur 54 patients diabétiques de type 2 suivis dans le service d'endocrinologie du CHU de Besançon ou par des médecins de ville, indique un déséquilibre glycémique significatif avec une augmentation de 0,5 point d'HbAlc. En parallèle, on observe une diminution significative du poids et de l'IMC, mais aussi une diminution significative du taux de HDL. L'arsenal thérapeutique du diabète de type 2 s'est développé ces dernières années. Cependant, depuis le retrait de la pioglitazone, seule la metformine agit sur l'insulinorésistance, composante à l'origine du développement et de l'évolution de la pathologie
Guidance on the Use of Pioglitazone for Type 2 Diabetes Mellitus
Author: National Institute for Clinical Excellence (Great Britain)Publisher:
ISBN: 9781842570760
Category : Diabetes
Languages : en
Pages : 13
Book Description
Textbook of Diabetes
Author: Richard I. G. HoltPublisher: John Wiley & Sons
ISBN: 1118912020
Category : Medical
Languages : en
Pages : 1104
Book Description
Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.
Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease
Author: Andrew J. KrentzPublisher: Springer
ISBN: 3030117480
Category : Medical
Languages : en
Pages : 557
Book Description
This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Prevention of Stroke
Author: John W. NorrisPublisher: Springer Science & Business Media
ISBN: 1475742266
Category : Medical
Languages : en
Pages : 280
Book Description
Prevention of Stroke sums up and critically analyzes our present knowledge and understanding of all major aspects of stroke prophylaxis, medical and surgical. The book is intended for not only neurologists and neurosurgeons directly involved with stroke patients, but also vascular surgeons, internists, family physicians, and health planners. Topics explored include the cellular basis of atherosclerosis; stroke risk factors; head and neck bruits in stroke prevention; the present status of anticoagulant prophylaxis; hypertension and stroke prevention; and prevention of cardioembolic stroke, as well as the efficacy of aspirin and of ticlopidine in stroke prevention. Surgical prophylaxis is examined through discussions of carotid endarterectomy, prevention of stroke from cerebral vascular malformations, prevention of aneurysmal subarachnoid hemorrhage, balloon transluminal angioplasty of the carotid artery in the head and neck, and prevention of recurrent stroke.
Canadian Journal of Physiology and Pharmacology
Author: International Textbook of Diabetes Mellitus
Author: R. A. DeFronzoPublisher: John Wiley & Sons
ISBN: 1118387678
Category : Medical
Languages : en
Pages : 1200
Book Description
The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Author: