Isolated Lung Perfusion with Gemcitabine for the Treatment of Pulmonary Metastases PDF Download

Author: Bart P. van Putte
Publisher:
ISBN: 9789039334799
Category :
Languages : en
Pages : 167

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Author: P. Van Schil
Publisher: Nova Publishers
ISBN: 9781594544507
Category : Isolation perfusion (Physiology)
Languages : en
Pages : 254

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Book Description
Surgical resection of lung metastases is a widely accepted procedure but long-term results are disappointing with a 5-year survival rate of approximately 40%. The main prognostic factor is complete resection and a better survival is reported in patients with a single metastasis and a disease-free survival of more than 3 years. Re-operations are feasible but often patients become inoperable due to insufficient pulmonary reserve and new treatment modalities are looked for. Intravenous (iv) chemotherapy has no major impact on survival due to systemic side-effects when high doses are given. As isolated limb and liver perfusion, isolated lung perfusion (ILuP) has the advantage of selectively delivering an agent into the lung while diverting the venous effluent. This allows the drug to be given in a significantly higher dose compared to iv therapy, while drug levels in the other organs are kept low enough to avoid major complications. ILuP has been shown to be very effective for the treatment of lung metastases in animal models. Phase I clinical studies to determine dose-limiting toxicity and maximum tolerated dose have recently been reported. The principal aim of this book is to discuss the current treatment of lung metastases and the possible contribution of ILuP.

Author: Paul van Schil
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Mark W. Onaitis
Publisher: Elsevier Health Sciences
ISBN: 0323417175
Category : Medical
Languages : en
Pages : 145

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Book Description
This issue of Thoracic Surgery Clinics of North America focuses on Pulmonary Metastasectomy. Articles will include: Biology of Pulmonary Metastases; Preoperative Evaluations and Indications for Metastasectomy; Open Approaches to Pulmonary Metastases: Thoracotomy and Sternotomy; Ablative Approaches for Pulmonary Metastases: RFA, microwave, SBRT; Role of Lymphadenectomy with Pulmonary Metastasectomy; Results of Pulmonary Resection: Colorectal Carcinoma; Results of Pulmonary Resection: Sarcoma and Germ Cell Tumors; Isolated Lung Perfusion; Immunotherapy; Medical Management of Pulmonary Metastases: Is There a Role for Surgery?; Thoracoscopic Management of Pulmonary Metastases; Results of Pulmonary Resection: Other Epithelial Malignancies; Thoracoscopic Lung Suffusion; and more!

Author: Mark W. Onaitis
Publisher: Elsevier Health Sciences
ISBN: 0323417167
Category : Medical
Languages : en
Pages : 145

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Book Description
This issue of Thoracic Surgery Clinics of North America focuses on Pulmonary Metastasectomy. Articles will include: Biology of Pulmonary Metastases; Preoperative Evaluations and Indications for Metastasectomy; Open Approaches to Pulmonary Metastases: Thoracotomy and Sternotomy; Ablative Approaches for Pulmonary Metastases: RFA, microwave, SBRT; Role of Lymphadenectomy with Pulmonary Metastasectomy; Results of Pulmonary Resection: Colorectal Carcinoma; Results of Pulmonary Resection: Sarcoma and Germ Cell Tumors; Isolated Lung Perfusion; Immunotherapy; Medical Management of Pulmonary Metastases: Is There a Role for Surgery?; Thoracoscopic Management of Pulmonary Metastases; Results of Pulmonary Resection: Other Epithelial Malignancies; Thoracoscopic Lung Suffusion; and more!

Author: Michelle A. Rudek
Publisher: Springer Science & Business Media
ISBN: 1461491355
Category : Medical
Languages : en
Pages : 828

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Book Description
There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development

Author: Kenneth L. Franco
Publisher: Lippincott Williams & Wilkins
ISBN: 1451154151
Category : Medical
Languages : en
Pages : 4752

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Book Description
Cardiothoracic Surgery Review covers all of the core knowledge necessary to pass the cardiothoracic boards or the cardiothoracic recertification exam. Each topic presents core information in two-to-four pages and concludes with a brief list of the most important references. The topics cover all areas in cardiothoracic surgery, including cardiac surgery, pediatric cardiac surgery, and thoracic surgery. Included with the book is a companion website featuring the fully searchable text and over 60 procedural videos. This topic-based review is ideal for anyone needing to rapidly reference an up-to-date knowledge base in cardiothoracic surgery, including cardiothoracic fellows, practitioners studying for recertification, and surgical nurses.

Author: Joseph LoCicero
Publisher: Lippincott Williams & Wilkins
ISBN: 149637231X
Category : Medical
Languages : en
Pages : 2512

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Book Description
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. The gold standard thoracic surgery reference for 45 years, Shields’ General Thoracic Surgery remains your #1 resource for comprehensive coverage of both open and endoscopic surgical techniques, with commentary from more than 150 global experts in the field. This two-volume masterwork covers all facets of thoracic disease, enhanced with dynamic audio and visual content, colorful graphics, and an authoritative analysis of the world’s literature and electronic data – making this 8th Edition the most extensive and concise collection of practical, complete information available for today’s busy clinician.

Author: Karl Reinhard Aigner
Publisher: Springer
ISBN: 3319287737
Category : Medical
Languages : en
Pages : 501

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Book Description
This book presents the full range of management techniques and practices used in induction chemotherapy – both systemic and locoregional - by experienced international groups within one accessible volume. It provides the latest information on the pioneering and cutting-edge practices employed in different institutions and documents the advantages of integrated treatment schedules. All those responsible for treating patients with locally advanced cancers may find new, interesting aspects of locoregional cancer management and will find this book to be an invaluable source of up-to-date information. Throughout the world, induction chemotherapy is being used as part of an integrated plan of management for locally advanced, solid tumors, while systemic chemotherapy is most commonly used to shrink primarily non-operable tumors. In cases of poorly or nonresponsive tumors, attempts have been made to administer chemotherapeutics via the arterial route in order to achieve higher localized drug exposure and response rates. Such therapies are being practiced worldwide in independent, remote departments in universities, teaching hospitals and clinical schools. Frequently, however, these teams remain relatively unaware of the work being done in other institutions, which may slow further progress.

Author: Thomas W. Shields
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781738897
Category : Medical
Languages : en
Pages : 1572

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Book Description
The leading comprehensive reference on thoracic surgery is now in its Sixth Edition. Coverage of surgical oncology has been expanded. This edition also features state-of-the-art video-assisted procedures, new chapters on tracheostomy, and new techniques for lung cancer and paraesophageal hernia. Organized by anatomic region, this two-volume work offers comprehensive guidelines on surgical management of all adult and pediatric conditions. Coverage includes detailed information on diagnostic procedures, preoperative assessment, postoperative care, and relevant basic science and physiology. More than 2,000 images, drawings, and photographs complement the text.