Iron Physiology and Pathophysiology in Humans PDF Download

Author: Gregory J. Anderson
Publisher: Springer Science & Business Media
ISBN: 1603274855
Category : Medical
Languages : en
Pages : 705

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Book Description
Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

Author: Jeremy H. Brock
Publisher: Bailliere Tindall Limited
ISBN:
Category : Medical
Languages : en
Pages : 512

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Book Description
An overview of human iron metabolism. This book reviews the metabolic importance of iron in evolution, the physiology and biochemistry of internal iron exchange, iron absorption and iron storage, the molecular regulation of cellular iron homeostasis and aspects of iron and disease.

Author: Robert Crichton
Publisher: John Wiley & Sons
ISBN: 9780470010297
Category : Medical
Languages : en
Pages : 484

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Book Description
Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron overloads and deficiencies are important factors in the health of humans and are therefore a key target in drug development. Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 3rd Edition presents a comprehensive overview of this important field.Topics covered include: Solution chemistry of iron in biological media The importance of iron for biological systems Microbial iron transport and metabolism Iron uptake by plants and fungi Cellular iron uptake and export in mammals Intracellular iron storage and biomineralization Intracellular iron metabolism and cellular iron homeostasis Iron absorption in mammals, with particular reference to man, and regulation of systemic iron balance Pathophysiology of iron deficiency and iron overload in man Iron and oxidative stress Brain iron homeostasis and its perturbation in various neurodegenerative diseases Interactions between iron and other metals Written in a lively style by one of the leaders in the field and presented in full colour, this third, expanded edition of Iron Metabolism has been fully updated with the latest discoveries. Major additions include recent information on mitochondrial iron metabolism and the role of frataxin; transcriptional control of iron homeostasis; orally active iron chelators; the roles of hepcidin and erythropoietin; the increasing number of types of iron overload; and the importance of iron in Alzheimer’s disease. Iron Metabolism is essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. It will also find space on the bookshelves of bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, and pharmacologists in the pharmaceutical industry interested in developing novel iron-binding drugs.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 9780309072793
Category : Medical
Languages : en
Pages : 804

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Book Description
This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Author: Kenneth Kaushansky
Publisher: McGraw Hill Professional
ISBN: 0071833013
Category : Medical
Languages : en
Pages : 2528

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Book Description
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2020! Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309039940
Category : Medical
Languages : en
Pages : 765

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Book Description
Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Author: Saurabh Mehta
Publisher: CRC Press
ISBN: 1351058185
Category : Medical
Languages : en
Pages : 326

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Book Description
The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations’ Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.

Author: Ananda Prasad
Publisher: Springer Science & Business Media
ISBN: 1468407937
Category : Medical
Languages : en
Pages : 396

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Book Description
Each year, it becomes more apparent that trace elements play an important role in human metabolism. The concept is no longer new. The literature on the subject is voluminous. Dr. Prasad, who has been interested in this field for many years, has undertaken the enormous task of bringing our knowledge together in a comprehensive fashion. This monograph should prove very informative and extremely useful to everyone who is concemed with human disease and with the maintenance of good health. His coverage of the subject is broad. Because ofthe importance of iron, in addition to "trace" elements, in human metabolism and nutrition, a chapter dealing with iron has been included. Maxwell M. Wintrobe, M.D. vii PREFACE It has been known for several decades that many elements are present in living tissues, but it was not possible to measure their precise concentra tions until recently. They were therefore referred to as occurring in "trace" amounts, and this practice led to the use of the term "trace elements." Although techniques now available are such that virtually alI trace elements can be determined with reasonable accuracy, the designation "trace ele ments" remains in popular usage.

Author: James C. Barton
Publisher: Cambridge University Press
ISBN: 9780521593809
Category : Medical
Languages : en
Pages : 622

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Book Description
Once thought rare, hemochromatosis is now acknowledged as one of the commonest inherited disorders, affecting one in two hundred people of western Caucasian descent. It is estimated to affect over one million people in the USA alone. This is the most comprehensive clinical reference yet on hemochromatosis. The international author team includes specialists in internal medicine, hematology, hepatology, genetics, biochemistry and molecular biology, and the contents cover all aspects of pathophysiology, epidemiology, diagnosis and treatment. The latest developments in the genetics of the disorder are well explained, and there are sections on screening, diagnostic techniques, and clinical complications. Social and ethical issues are also considered. Highly illustrated, up-to-date and authoritative, this is the definitive resource for all clinicians involved in the management of hemochromatosis, and will also be invaluable to scientists interested in iron metabolism and iron overload.

Author: Carla E. M. Hollak
Publisher: Oxford University Press
ISBN: 0199972133
Category : Medical
Languages : en
Pages : 657

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Book Description
As clinical management of inherited metabolic diseases (IMDs) has improved, more patients affected by these conditions are surviving into adulthood. This trend, coupled with the widespread recognition that IMDs can present differently and for the first time during adulthood, makes the need for a working knowledge of these diseases more important than ever. Inherited Metabolic Disease in Adults offers an authoritative clinical guide to the adult manifestations of these challenging and myriad conditions. These include both the classic pediatric-onset conditions and a number of new diseases that can manifest at any age. It is the first book to give a clear and concise overview of how this group of conditions affects adult patients, a that topic will become a growing imperative for physicians across primary and specialized care.