Investigating SMAD Involvement in Transforming Growth Factor-beta Signal Transduction PDF Download

Author: Michael Benjamin Major
Publisher:
ISBN:
Category : Cellular signal transduction
Languages : en
Pages : 350

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Book Description

Author: Aristidis Moustakas
Publisher: Springer Science & Business Media
ISBN: 4431544097
Category : Science
Languages : en
Pages : 463

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Book Description
Transforming growth factor-β (TGF-β) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-β now is rather well understood. Continuing revelations in the mechanisms of action of TGF-β provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-β pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-β is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-β action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-β field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-β biology is disseminated to the world of science and to the public.

Author: Sonia B. Jakowlew
Publisher: Springer Science & Business Media
ISBN: 1588297144
Category : Medical
Languages : en
Pages : 726

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Book Description
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Author: Sonia B. Jakowlew
Publisher: Springer Science & Business Media
ISBN: 1597452939
Category : Medical
Languages : en
Pages : 785

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Book Description
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

Author: Sonia B. Jakowlew
Publisher: Springer Science & Business Media
ISBN: 1597452920
Category : Medical
Languages : en
Pages : 726

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Book Description
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Author: Rik Derynck
Publisher: CSHL Press
ISBN: 0879697520
Category : Transforming growth factors-beta
Languages : en
Pages : 1108

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Book Description
Transforming growth factor-[beta] (TGF-[beta]), identified nearly three decades ago, is a secreted polypeptide that functions in critical cell cycle processes, including cellular proliferation, differentiation, and development: It belongs to a large protein family that, in humans, contains 33 members, including activins, inhibins, bone morphogenetic proteins, growth and differentiation factors, and Mullerian inhibiting substance. This volume draws on the world's leading laboratories to comprehensively cover all aspects of the biology of TGF-[beta] and related factors. In addition to providing historical and background information, it describes the cell biology and signaling pathways of TGF-[beta] members in detail, including the roles of TGF-[beta] factors in the development and physiology of humans and model organisms. The last few chapters are devoted to the role of TGF-[beta] members in cancer and other diseases, as well as the possibilities for therapeutics based on knowledge of signaling pathways and macromolecular structures. It serves as a comprehensive reference work for both specialists and researchers less familiar with the field.

Author: Xin-Hua Feng
Publisher:
ISBN: 9781493929665
Category : Cellular signal transduction
Languages : en
Pages : 394

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Book Description

Author: Peter Dijke
Publisher: Springer Science & Business Media
ISBN: 1402047096
Category : Science
Languages : en
Pages : 489

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Book Description
This is the first comprehensive book on Smad signal transduction. Forward looking reviews of Smads are provided in a series of 22 cutting-edge chapters. The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.

Author: Daniel Ethan Nicklas
Publisher:
ISBN: 9781321020564
Category :
Languages : en
Pages :

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Book Description
The transforming growth factor-[beta] (TGF-[beta]) signal transduction pathway controls many cellular processes, including growth, differentiation, apoptosis, and tissue homeostasis. It plays a fundamental role during development and is dysregulated in a number of human diseases, including cancer, vascular disease, and fibrotic conditions, through mutations of its core components. The work presented here investigates signaling in this pathway using mathematical modeling and computational analysis in two primary components. First, it is shown that the new model presented here accurately reproduces experimental behavior in three distinct cell lines, highlighting the role of negative feedback and coupled signaling as key determinants in differentiating the cell-specific dynamic responses to ligand stimulation. The negative feedback loop is further investigated in a variety of distinct motifs for its effect on signaling dynamics, robustness to systemic perturbations, and sensitivity to perturbations of individual processes in the pathway.The second primary component of this work combines methods used in the first component to develop a novel approach to identify potential therapeutic targets and apply it to the TGF-[beta] signaling pathway model. This approach determines therapeutic targets that may restore normal signaling dynamics to the system when its components are mutated while maintaining the dynamics of the normal system substantially unperturbed in the presence of the therapeutic intervention to reduce the potential risk of side effects. This method is then generalized and automated through development of a software package so that it may be readily applied to models of any biochemical system, providing an efficient starting point for further experimental and clinical investigation in the development of novel therapeutics.

Author: Zhike Zi
Publisher: Humana
ISBN: 9781071622797
Category : Sports & Recreation
Languages : en
Pages : 0

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Book Description
This detailed volume is devoted to the recent development of quantitative experiments and computational methods driving new transforming growth factor beta (TGF-β) and other cell signaling knowledge. Many chapters cover quantitative assays for TGF-β signaling studies, with others exploring the increasing role of both modeling and computational methods. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, TGF-Beta Signaling: Methods and Protocols serves as a vital resource for researchers seeking to move the TGF-β field into the quantitative realm.