Introduction To Organ Transplantation (2nd Edition) PDF Download

Author: Nadey S Hakim
Publisher: World Scientific
ISBN: 1908977612
Category : Medical
Languages : en
Pages : 265

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Book Description
This second edition of the introduction to the field of organ transplantation provides an excellent overview of the tremendous progress made in recent decades, and gives a clear description of the current status of transplant surgery for students and trainees with an interest in this field. It opens with introductory chapters on the history of transplantation and the basic science of immunobiology, and then examines through an organ-based structure the practice of transplantation in each major system, from skin to intestine. There is a 13-year gap between the first and second edition, and this is highlighted in the new collection of chapters of this updated version. This is a timely publication produced in line with the rapidly advancing field of transplantation.The editor, Nadey S Hakim, is a consultant transplant and general surgeon at Imperial College Healthcare NHS Trust, London, England, and has put together this second volume that will serve as an invaluable guide for transplant surgeons as well as trainees.

Author: Nadey Hakim
Publisher: World Scientific
ISBN: 1848168543
Category : Medical
Languages : en
Pages : 265

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Book Description
This second edition of the introduction to the field of organ transplantation provides an excellent overview of the tremendous progress made in recent decades, and gives a clear description of the current status of transplant surgery for students and trainees with an interest in this field. It opens with introductory chapters on the history of transplantation and the basic science of immunobiology, and then examines through an organ-based structure the practice of transplantation in each major system, from skin to intestine. There is a 13-year gap between the first and second edition, and this is highlighted in the new collection of chapters of this updated version. This is a timely publication produced in line with the rapidly advancing field of transplantation. The editor, Nadey S Hakim, is a consultant transplant and general surgeon at Imperial College Healthcare NHS Trust, London, England, and has put together this second volume that will serve as an invaluable guide for transplant surgeons as well as trainees.

Author: Frank P. Stuart
Publisher: CRC Press
ISBN:
Category : Medical
Languages : en
Pages : 644

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Book Description
Organ transplantation is increasingly complex and at the same time increasingly effective. The lengthening waiting list for cadaver organs now exceeds the supply several-fold. Most practicing physicians encounter only a few transplant recipients during a year of practice. This volume was written as a quick, but comprehensive, reference for medical students, residents, fellows, nurses, and practicing physicians who interface intermittently with recipients and transplant teams. It contains twentyone chapters and twelve essays; together they present the standard of practice and also controversial issues such as the ethical dilemma of long waiting lists, noncompliance with long-term immunosuppression, the relationship between acute and chronic rejection, the living organ donor, the older cadaver donor, laparoscopic nephrectomy, retransplantation, organ banks and the national transplant network’s criteria for allocating organs to potential recipients, and the promise of xenotransplantation. Appendix I includes detailed information about immunosuppressive drugs.

Author: Menna Clatworthy
Publisher: John Wiley & Sons
ISBN: 1118308549
Category : Medical
Languages : en
Pages : 116

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Book Description
The first basic overview of all aspects of transplantation with a clarity not to be found in more inaccessible textbooks. This brand new title provides a succinct overview of both the scientific and clinical principles of organ transplantation and the types of organ transplant, featuring highly-illustrated information covering core topics in transplantation including: Organ donors Organ preservation Assessment of transplant recipients Indications for transplantation Immunology of transplantation Immunosuppression and its complications Overviews of thoracic and abdominal organ transplantation, including the kidneys, liver, heart and lungs Transplantation at a Glance is the ideal introduction for medical students, junior doctors, surgical trainees, immunology students, pharmacists, and nurses on transplant wards.

Author: International Transplant Nurses Society
Publisher: Nursesbooks.org
ISBN: 1558102663
Category : Medical
Languages : en
Pages : 75

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Book Description
This specialty standard focuses on protecting, promoting, and optimizing the health and abilities of both the recipents and the living transplant donors of transplanted across the life span. It is also an essential document for other specialists in transplant care, healthcare providers, researchers, and scholars, along with those involved in funding, legal, policy, and regulatory activities.

Author: Arthur S M Lim
Publisher: World Scientific
ISBN: 9814471763
Category : Medical
Languages : en
Pages : 109

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Book Description
Throughout history, men have repeatedly made judgments regarding their own conduct and that of their fellow men. Some acts have been judged to be right or good, while other acts have been denounced as wrong or evil. Ethical judgment in medicine, as in other areas of life, is an attempt to distinguish between good and bad conduct.This book is based on three lectures given by the author as the Medical Director of Eye Clinic Singapura International. The first lecture was an address delivered to medical undergraduates at the National University of Singapore in 1975. The second was a Commonwealth Medical Association lecture delivered a decade ago. The third was a Singapore Medical Association lecture delivered in 1981. This volume, emphasizing the principles of medical ethics, has been kept simple and brief, and it is hoped that it will make interesting reading for both medical professionals and the general public.

Author: Ulrike Koehl
Publisher: Frontiers Media SA
ISBN: 2889456633
Category : Immunologic diseases. Allergy
Languages : en
Pages : 407

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Book Description
Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the understanding of NK cell biology, these studies are critical for effective translation of NK-based immunotherapy principles into the clinic. In humans, dominant inhibitory signals are transduced by Killer Immunoglobulin Like Receptors (KIR) recognizing cognate HLA class I on target cells. Conversely, KIR recognition of “missing self-HLA” - due to HLA loss or HLA/ KIR mismatch - triggers NK-mediated tumor rejection. Initially observed in murine transplant models, these antitumor effects were later found to have important implications for the clinical outcome of haplotype-mismatched stemcell transplantation. Here, donor NK subsets protect against acute myeloid leukemia (AML) relapse through missing self recognition of donor HLA-C allele groups (C1 or C2) and/or Bw4 epitope. These studies were subsequently extended by trials investigating the antileukemia effects of adoptively transferred haplotype-mismatched NK cells in non-transplant settings. Other mechanisms have been found to induce clinically relevant NK cell alloreactivity in transplantation, e.g., post-reconstitution functional reversal of anergic NK cells. More recently, activating KIR came into the spotlight for their potential ability to directly activate donor NK cells through in vivo recognition of HLA or other ligands. Novel therapeutic monoclonal antibodies (mAb) may optimize NK-mediated effects. Examples include obinutuzumab (GA101), a glyco-engineered anti-CD20 mAb with increased affinity for the FcγRIIIA receptor, enhancing antibody-dependent cellular cytotoxicity; lirilumab (IPH2102), a first-in-class NK-specific checkpoint inhibitor, blocking the interaction between the major KIR and cognate HLA-C antigens; and elotuzumab (HuLuc63), a humanized monoclonal antibody specific for SLAMF7, whose anti-myeloma therapeutic effects are partly due to direct activation of SLAMF7-expressing NK cells. In addition to conventional antibodies, NK cell-targeted bispecific (BiKEs) and trispecific (TriKEs) killer engagers have also been developed. These proteins elicit potent effector functions by binding target ligands (e.g., CD19, CD22, CD30, CD133, HLA class II, EGFR) on one arm and NK receptors on the other. An additional innovative approach to direct NK cell activity is genetic reprogramming with chimeric antigen receptors (CAR). To date, primary NK cells and the NK92 cell line have been engineered with CAR specific for antigens expressed on multiple tumors. Encouraging preclinical results warrant further development of this approach. This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands.

Author: Seyed Morteza Naghib
Publisher: Frontiers Media SA
ISBN: 2832553982
Category : Science
Languages : en
Pages : 131

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Book Description
Most drugs are toxic to cells that often kill healthy cells and establish several side effects. Conventional chemotherapy cargoes are not tumor-specific and commonly their nature leads to significant toxic effects on healthy tissues. Therefore, several drug delivery systems (DDSs) were developed to amend the therapeutic properties of drugs and made them safer and more effective. Local drug delivery which decreases systemic drug exposure, is an important approach for maximal efficacy, high levels of patient compliance, and fewer side effects. Smart drug delivery systems (SDDSs) have gained much attention and paved the way for more effective treatment of patients. SDDSs with stimuli-responsive characteristics are determined as the process that the payloads are not released before reaching the target site. This triggered release occurs due to the variations in the nano/microcarrier chemistry and structure, in response to endogenous and/or exogenous stimulus, establishing the release of the cargoes to the exact place. Responsive and smart materials/biomaterials are responsive/sensitive to signals originating from physiological systems, or to abnormalities originating from pathological defects, that can interact with or be triggered by the biological environments, and are interesting in drug delivery platforms/devices for developing next-generation accurate medicines. In exogenous-triggered delivery, drug/gene release is controlled by external stimulus, which can be controlled exactly. Different exogenous triggers have been reported, such as light, magnetic field, temperature, electrical field, and ultrasound. The endogenous triggers such as pH, redox, enzyme concentration, and bio-molecules are related to the disease's pathological characteristics. Disease pathological characteristics are key parameters as physiological triggers for designing programmed delivery devices that may be used for the non-invasive and effective treatment of a wide range of pathological conditions such as cancer, infections, diabetes, cardiovascular diseases, autoimmune disorders, stroke, and chronic wounds, and degenerative diseases. Endogenously triggered drug release is the same as exogenously triggered drug release, which can lead to enhanced release of therapeutic molecules at the target place in its therapeutic concentration, reducing local toxicity and side effects, reducing the need for repeat administrations, and increasing patient compliance. Here, we focused on smart endogenous and exogenous stimuli-responsive biomaterials for programmed drug delivery. The conventional drug delivery systems are not without any limitations and challenges. One of the most important challenges is related to their degradability or insufficient biocompatibility of most materials which are used in smart delivery system. Another challenge is related to the using of 2D in vitro models or in vivo animal studies to evaluate the performance of these systems, and there is a poor relation between such results and human clinical trials. Thus, these incompatibilities can lead to the failing of the numerous smart systems in clinical studies. In this special issue, we focus on smart multi-responsive drug delivery systems that can address some challenges and drawbacks. Research paper, commutation (letter), mini-review and review are acceptable for publications in this special issue. Main topics: 1- Smart exogenous-triggered delivery systems 2- Smart endogenous-triggered delivery systems 3- Multi-responsive targeted vehicles 4- Stimuli-responsive niosomes and liposomes 5- Multifunctional biomaterials for cancer treatment 6- Smart 3D and 4D scaffolds for localized delivery systems

Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :

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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author: Stacee Lerret
Publisher: Lippincott Williams & Wilkins
ISBN: 149635186X
Category : Medical
Languages : en
Pages : 1183

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Book Description
An official publication of the International Transplant Nurses Association, the updated Second Edition provides a guide to safe and effective care for solid organ transplant recipients worldwide. It includes coverage of the unique requirements of each organ transplanted, with separate chapters for heart, lung, kidney, liver, small intestine, and pancreas/islet cell transplantation. Other chapters cover important topics that affect all organs, such as immunology, infections, pharmaceutical agents, and patient education and discharge planning. The Core is an ideal review and study guide for the solid organ.