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Author: Timo Partonen Publisher: Frontiers Media SA ISBN: 2889454517 Category : Languages : en Pages : 117
Book Description
"Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called “clock genes.”
Author: Timo Partonen Publisher: Frontiers Media SA ISBN: 2889454517 Category : Languages : en Pages : 117
Book Description
"Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called “clock genes.”
Author: Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
"Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called "clock genes."
Author: Steve Adams Publisher: CRC Press ISBN: 1135739706 Category : Science Languages : en Pages : 304
Book Description
Provides the essential principles and results of special relativity as required by undergraduates. The text uses a geometric interpretation of space-time so that a general theory is seen as a natural extension of the special theory. Although most results are derived from first principles, complex and distracting mathematics is avoided and all mathe
Author: Achim Kramer Publisher: Springer Science & Business Media ISBN: 3642259502 Category : Medical Languages : en Pages : 414
Book Description
This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.
Author: D. S. Saunders Publisher: Elsevier ISBN: 1483182185 Category : Science Languages : en Pages : 290
Book Description
Insect Clocks is mainly concerned with the phenomena in which ""environmental time"" has a practical implication for the life of insects for them to perform behavioral or physiological episodes at the ""right time"" and season. This text first discusses the concept of rhythms and clocks, along with the seasonal changes in the environment that affect a particular group of organisms. This book then explains circadian rhythms of insects. Photoperiodism and seasonal cycles of development; photoperiodic response, clock, and counter; and other types of insect clock are also tackled. This text concludes by explaining the anatomical location of photoreceptors and clocks. This publication will be invaluable to those interested in studying insects and their development affected by circles of influences.
Author: George E. Billman Publisher: Frontiers Media SA ISBN: 288919647X Category : Physiology Languages : en Pages : 143
Book Description
The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that’s prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. The question then is what went wrong, why have these interventions proven to be so ineffective? An obvious answer is the drugs were designed to attack the wrong therapeutic target. Clearly, targeting single ion channels (using either isolated ion channels or single myocytes preparations) has proven to be less than effective. What then is the appropriate target? It is well established that cardiac electrical properties can vary substantially between single cells and intact preparations. One obvious example is the observation that action potential duration is much longer in isolated cells as compared to multi-cellular preparations or intact hearts. Due to the low electrical resistance between adjacent myocytes, the cells act in coordinated fashion producing “electrotonic interdependence” between neighboring cells. Myocardial infarction and/or acute ischemia provoke profound changes in the passive electrical properties of cardiac muscle. In particular, electrotonic uncoupling of the myocytes disrupts the coordinated activation and repolarization of cardiac tissue. The resulting compensatory changes in ionic currents decrease cardiac electrical stability increasing the risk for life-threatening changes in the cardiac rhythm. Thus, the electrical properties of myocardial cells must be considered as a unit rather than in isolation. It is the purpose of this Research Topic to evaluate the largely neglected relationship between changes in passive electrical properties of cardiac muscle and arrhythmia formation.
Author: Jay C. Dunlap Publisher: Sinauer Associates, Incorporated ISBN: 9780878933969 Category : Chronobiology Languages : en Pages : 0
Book Description
This book covers circadian rhythmicity; analyses of the behavioural and ecological importance of rhythms and their theoretical bases; the comparative anatomy, physiology, genetics and molecular biology of organisms within circadian clocks; real-world examples; classic research and 6 cutting-edge research areas.
Author: R. T. Mullins Publisher: Oxford University Press ISBN: 0191071447 Category : Religion Languages : en Pages : 275
Book Description
The claim that God is timeless has been the majority view throughout church history. However, it is not obvious that divine timelessness is compatible with fundamental Christian doctrines such as creation and incarnation. Theologians have long been aware of the conflict between divine timelessness and Christian doctrine, and various solutions to these conflicts have been developed. In contemporary thought, it is widely agreed that new theories on the nature of time can further help solve these conflicts. Do these solutions actually solve the conflict? Can the Christian God be timeless? The End of the Timeless God sets forth a thorough investigation into the Christian understanding of God and the God-world relationship. It argues that the Christian God cannot be timeless.
Author: Oliver Vonend Publisher: BoD – Books on Demand ISBN: 953307616X Category : Medical Languages : en Pages : 210
Book Description
Outstanding steps forward were made in the last decades in terms of identification of endogenous pacemakers and the exploration of their controllability. New "artifical" devices were developed and are now able to do much more than solely pacemaking of the heart. In this book different aspects of pacemaker - functions and interactions, in various organ systems were examined. In addition, various areas of application and the potential side effects and complications of the devices were discussed.
Author: Timo Partonen
Author: Timo Partonen
Author: 
Author: Steve Adams
Author: Charles A. Czeisler
Author: Achim Kramer
Author: D. S. Saunders
Author: George E. Billman
Author: Jay C. Dunlap
Author: R. T. Mullins
Author: Oliver Vonend