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Author: Ian Graham Publisher: Springer Science & Business Media ISBN: 1461557712 Category : Medical Languages : en Pages : 396
Book Description
This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described. To date, evidence strongly supports the hypotheses that Hyperhomocysteinemia is a strong independent determinant of vascular disease and Many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins.£/LIST£ The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions. Against this background of growing recognition of the importance of homocysteine as a factor in coronary artery disease, cerebrovascular disease, stroke, and peripheral vascular disease, the editors conceived of a state-of-the-art monograph on homocysteine and its relationships to disease. The contributors would be those scientists who, in fact, had written the history of this field of study over the past third of a century. The editors invited the leading investigators in the world to contribute chapters in their own areas of expertise to this monograph and to deliver those papers at the first International Meeting on Homocysteine in Ireland, which has emerged as an important study center and where the first cases of homocystinuria were reported more than three decades ago.
Author: Ian Graham Publisher: Springer Science & Business Media ISBN: 1461557712 Category : Medical Languages : en Pages : 396
Book Description
This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described. To date, evidence strongly supports the hypotheses that Hyperhomocysteinemia is a strong independent determinant of vascular disease and Many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins.£/LIST£ The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions. Against this background of growing recognition of the importance of homocysteine as a factor in coronary artery disease, cerebrovascular disease, stroke, and peripheral vascular disease, the editors conceived of a state-of-the-art monograph on homocysteine and its relationships to disease. The contributors would be those scientists who, in fact, had written the history of this field of study over the past third of a century. The editors invited the leading investigators in the world to contribute chapters in their own areas of expertise to this monograph and to deliver those papers at the first International Meeting on Homocysteine in Ireland, which has emerged as an important study center and where the first cases of homocystinuria were reported more than three decades ago.
Author: Christina Bolander-Gouaille Publisher: Springer Science & Business Media ISBN: 2817807596 Category : Medical Languages : en Pages : 224
Book Description
While research on homocysteine and vitamins involved in its metabolism has focused on associations with cardiovascular disease, pregnancy complications and fetal malformations, recent research explores connections between homocysteine metabolism and neuropsychiatric disease, particularly cognitive decline and dementia. If homocysteine-lowering vitamin treatment can reduce the incidence or delay the onset of dementia, the impact would be significant. This book summarises current research, reviews the underlying biochemistry and surveys diagnostic aspects.
Author: Christina Bolander-Gouaille Publisher: Springer Science & Business Media ISBN: 2817808452 Category : Medical Languages : en Pages : 261
Book Description
During the last 10-12 years, the research on homocysteine has become very active. About 1500 of articles are now published each year on homocysteine and the vitamins involved in its metabolism. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalised by treatment with folate and/or vitamines B12 and B6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialised journals. The author has realised the difficulties for the practitioner in keeping updated. This second edition has been thoroughly updated and also offers more data on the vitamins. Over 1600 references are made available.
Author: Kilmer McCully Publisher: Harper Collins ISBN: 0061746614 Category : Health & Fitness Languages : en Pages : 265
Book Description
A revolutionary and practical approach to preventing heart diseases, improving health and promoting life-long wellness. In this groundbreaking book, Dr. Kilmer S. McCully explains what is really behind the epidemic of heart disease. For many years, clogged arteries have been inaccurately viewed as the cause, rather than a symptom, of heart disease. Now, McCully shows you how to cut your risk of heart disease by controlling the real culprit, homocysteine. Considered one of the most significant medical breakthroughs in recent years, McCully's findings have been validated by numerous large-scale studies.
Author: Ricki Lewis Publisher: John Wiley & Sons ISBN: 1444313134 Category : Science Languages : en Pages : 251
Book Description
The goal of Discovery: Science as a Window to the World is to relay the excitement of sciene by exploring selected topics in biology and medicine in a way that reveals the process of discovery. Each chapter will focus on the curiosity and creativity that drives scientists to wonder, observe, question and experiment. One impetus for this project is the recognition of a growing demand among instructors for a book that departs from fact-stuffed textbooks and instead engages students in the discovery process at a personal level. Emphasizes the process of discovery through interviews and key experiments. Written by a best-selling author. Provides an in-depth, conversational look at the science behind several "hot topics" in biology. Each chapter traces the beginnings of the field with stories of how serendipity and scientific inquiry intertwine. Presents the background to a field by including the scientific literature-so the reader does not have to do a literature search or plow through a review article. Many essays introduce the work of overlooked scientists or "unsung heroes." Alexey Olovnikov (telomeres), Leroy Steven (stem cells), to name a few. Also, well-known scientists are interviewed: Stanley Miller, Carl Woese, John Gearhart, and others. The essays show how ideas interact and coalesce from different lines of research. Highlights the role of the media in interpreting science for the public.
Author: Per Magne Ueland Publisher: CRC Press ISBN: 1498713882 Category : Medical Languages : en Pages : 225
Book Description
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in both folate and homocysteine metabolism. It first achieved medical recognition in 1972 with the report of severe deficiency of MTHFR in a patient with homocystinuria, an inborn error of metabolism characterized by marked elevation of homocyst(e)ine in plasma and urine. Although the majority of cases of homocystinuria are due to a deficiency of the first enzyme in the transsulfuration pathway for homocysteine metabolism, cystathionine-ß-synthase (CBS), disruption of homocysteine remethylation to methionine can also result in homocystinuria. With the identification of additional patients with severe MTHFR deficiency, the heterogeneity of this disorder became manifest. This book covers many of the complex traits that have been reported to be influenced by the well-characterized 677C→T variant; there is less information on the 1298A→C variant, but it is discussed where appropriate. It is quite surprising, and unique, that a single variant should influence such a wide variety of clinical conditions.
Author: Adrianne Bendich Publisher: Springer ISBN: 331922431X Category : Medical Languages : en Pages : 913
Book Description
This newly expanded and updated fifth edition will be the largest and most comprehensive of the five editions and new topics and chapter authors have been added. The authors have created the most comprehensive and up-to-date review of the nutritional strategies available for the prevention of disease and the promotion of health through nutrition. Patients are looking for credible information from their health care providers about a whole range of subjects covered here, including ß-carotene, lycopene, antioxidants, folate, and the myriad of bioactive phytochemicals found in garlic and other foods. With sections on cardiovascular disease, diabetes, and pregnancy among many others, this volume will be of great value to practicing health professionals, including physicians, nutritionists, dentists, pharmacists, dieticians, health educators, policy makers, health economists, regulatory agencies and research investigators. An entire section covers nutrition transitions around the world including Eastern Europe, Latin America and Asia as well as goals for preventive nutrition in developing countries. Preventive Nutrition: The Comprehensive Guide for Health Professionals, 5th Ed. is an important resource for thousands of health professionals who have been utilizing the previous editions since 1997.
Author: Dominic J. Harrington Publisher: Academic Press ISBN: 0128130512 Category : Medical Languages : en Pages : 342
Book Description
Laboratory Assessment of Vitamin Status provides a comprehensive understanding of the limitations of commonly used approaches used for the evaluation of vitamin status, reducing harm in the general health setting. It outlines the application of 'Best Practice' approaches to the evaluation of vitamin status, giving physicians and other healthcare professionals the opportunity to make evidence-based interventions. Nearly every metabolic and developmental pathway in the human body has a dependency on at least one micronutrient. Currently, the clinical utility of approaches taken by laboratories for the assessment of vitamin status is generally poorly understood, missing the opportunity to diagnosis vitamin deficiencies. This essential reference gives clinical and biomedical scientists an understanding of the limitations of commonly used approaches to the evaluation of vitamin status in the general health setting through change in practice. Nutritionists and dietitians gain an understanding of more sophisticated markers of vitamin status. - Describes specialist assays in sufficient detail to enable laboratories to replicate what is being performed by expert groups - Provides detailed information that supports laboratories in the setting up of methods for the evaluation of vitamin status - Informs laboratories looking for third party providers of specialist investigations - Provides an essential overview of reference ranges for each vitamin
Author: Ian Graham
Author: Ian Graham
Author: Christina Bolander-Gouaille
Author: Christina Bolander-Gouaille
Author: Kilmer McCully
Author: Ricki Lewis
Author: 
Author: Per Magne Ueland
Author: British Library. Document Supply Centre
Author: Adrianne Bendich
Author: Dominic J. Harrington