Interleukin-6: Biology-pathophysiology-therapy PDF Download

Author: Stefan Rose-John
Publisher:
ISBN:
Category :
Languages : en
Pages : 104

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Author: Kazuwa Nakao
Publisher: Springer
ISBN: 4431556516
Category : Science
Languages : en
Pages : 330

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Book Description
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Author: Andrzej Mackiewicz
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 554

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Book Description
This volume discusses the role of interleukin-6-type cytokines in haematopoietic cell proliferation, neuronal differentiation and acute phase response to inflammation. New data is presented concerning the structure and function of interleukin-6, the leukemia inhibitory factor, interleukin-11, oncostatin M and the ciliary neurotrophic factor. Also discussed is cytokine receptor function, common signal transduction mechanisms, the molecular basis of cytokine-mediated alterations in gene expression, and regulation of cell proliferation. Pre-clinical and clinical studies with these cytokines are evaluated.

Author: Randy Q. Cron
Publisher: Springer Nature
ISBN: 303022094X
Category : Medical
Languages : en
Pages : 607

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Book Description
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.

Author: Sameek Roychowdhury
Publisher:
ISBN:
Category : Interleukin
Languages : en
Pages :

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Abstract: A dysregulated immune system that is either too weak or too strong may lead to disease states such as cancer or autoimmunity. Specifically, this dissertation presents data on a growth factor, interleukin-15 (IL-15), and its pre-clinical application for cancer treatment and its role in the pathophysiology of graft-versus-host disease (GVHD). Provision of tumor-specific T cells, or adoptive immunotherapy, has emerged as a valid approach for prevention or treatment of human cancers such as melanoma and Epstein Barr virus-positive lymphoma. To improve immunotherapy, we hypothesized that IL-15 could be applied as a single agent to enhance tumor immunity through the maintenance of tumor specific CD8+ memory T cells. Tumor-bearing mice were treated with an adoptive transfer of transgenic tumor specific T cells and then randomized to receive daily low dose IL-15 or PBS treatment. Mice receiving tumor-specific T cells and IL-15 experienced a significantly delayed tumor relapse or no relapse at all. Analysis of peripheral blood 21 days after adoptive transfer demonstrated the persistence of tumor specific T cells in mice treated with IL-15 as compared to PBS. These data support the notion that low dose exogenous IL-15 can sustain tumor-specific T cells in vivo and result in clinical benefit. IL-15 is a pleiotropic pro-inflammatory cytokine with inefficient post-transcriptional processing. We hypothesized that alteration of endogenous IL-15 gene regulation could adversely impact disease progression in the well described C57Bl/6 (B6)> (C57Bl/6 x DBA/2)F1 (B6D2F1) murine model of acute allogeneic graft versus host disease (GVHD). B6D2F1 allogeneic recipients were transplanted with B6 bone marrow cells expressing a murine IL-15 transgene (IL-15 tg) modified for efficient translation and secretion. These mice had a dramatically decreased median survival time (MST) compared to mice transplanted with wild type (wt) B6 bone marrow. Blinded analysis of histopathology revealed a significant increase in intestinal epithelial damage and inflammation of the liver. The new findings discussed here suggest that IL-15 may be a valuable component of cancer therapies that aim to expand and maintain tumor-specific T cells, but that it also may have adverse side effects when applied in the setting of allogeneic bone marrow transplantation.

Author: Martin Wehling
Publisher: Academic Press
ISBN: 0128007214
Category : Science
Languages : en
Pages : 365

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Book Description
Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Author: J.R. Carey
Publisher: Springer Science & Business Media
ISBN: 3540273883
Category : Medical
Languages : en
Pages : 168

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Book Description
Understanding the relationship between frailty and longevity becomes increasingly important as the world continues to age and life expectancy in most countries continues to increase. The articles contained in this book are the outcome of a colloquium sponsored by Fondation IPSEN in which interdisciplinary perspectives were brought to bear on conceptual, empirical and clinical aspects of this relationship.

Author: Xiaojing Ma
Publisher: Springer
ISBN: 9402409211
Category : Medical
Languages : en
Pages : 228

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Book Description
This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.

Author: Ian R. Mackay
Publisher:
ISBN: 9781461492092
Category : Clinical immunology
Languages : en
Pages :

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Book Description
Offering a broad appeal to microbiologists, immunologists, and infectious disease specialists, this four volume encyclopedia covers all autoimmune, tropical, and infectious diseases. Emphasis will also be placed on genetics, physiology, metabolism, pathogenesis and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia will bring together an outstanding collection of contributions by top scientists in a variety of fields. Volumes 1-3: Diseases will be divided by the 11 main sections of the body, namely Integumentary, Skeletal, Respiratory, Digestive, Urinary, and Reproductive. For some of the autoimmune disease, more then one system will be involved but the delineation serves to broadly break down the diseases into systems. Volume 4 will cover the vaccines for said diseases and future prospects will be offered by leaders in industry and academia. Volume 4 will also be broken down into all the body systems, as in the other two volumes. For each vaccine, for each disease, and in each system the following will be included: • A list of the vaccines currently available along with a list of the companies that manufacture them • Molecular Immunology of the Vaccine • Type of Immunity involved in protection • Mode of Vaccination for each vaccine; repeated boosters and length of immunological memory • Commercial production of vaccines • Storage of vaccines • Standardization and Control of Vaccines • WHO programs and World-Wide Disease Eradication Programs based upon Vaccines.

Author: Marc Feldmann
Publisher: Springer Science & Business Media
ISBN: 1461249961
Category : Medical
Languages : en
Pages : 384

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Book Description
Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs.