Integrin Expression at the Bone/biomaterial Interface PDF Download

Author: Susan Agnes Clarke
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: John Edward Davies
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 524

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Book Description
Based on the proceedings of the Bone-Biomaterial Interface Workshop held in Toronto, Canada, December 1990, addresses the questions which have arisen during this period of evolution from inert to active materials in orthopedic, dental, and maxillofacial implants with specific reference to the bone-biomaterial interface. The seven parts of the volume reflect the seven sessions of the workshop, dealing with materials issues, protein adsorption, cell and tissue reactions, mechanical influences on interfacial biology, retrieval analysis, and the industrial context. Annotation copyrighted by Book News, Inc., Portland, OR

Author: J.E. Ellingsen
Publisher: CRC Press
ISBN: 0203491432
Category : Medical
Languages : en
Pages : 467

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Achieving good clinical outcomes with implanted biomaterials depends upon achieving optimal function, both mechanical and biological, which in turn depends upon integrating advances realized in biological science, material science, and tissue engineering. As these advances push back the frontiers of biomaterial medicine , the control and patterning

Author: Benjamin George Keselowsky
Publisher:
ISBN:
Category : Biomedical engineering
Languages : en
Pages :

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Book Description
Cell adhesion to proteins adsorbed onto implanted surfaces is particularly important to host responses in biomedical and tissue engineering applications. Biomaterial surface properties influence the type, quantity and functional presentation (activity) of proteins adsorbed upon contact with physiological fluids, and modulate subsequent cell response. Cell adhesion to extracellular matrix proteins (e.g. fibronectin) is primarily mediated by the integrin family of cell-surface receptors. Integrins not only anchor cells, supporting cell spreading and migration, but also trigger signals that regulate survival, proliferation and differentiation. A fundamental understanding of the adhesive interactions at the biomaterial interface is critical to the rational design of biomaterial surfaces. Using model surfaces of self-assembled monolayers of alkanethiols on gold presenting well-defined surface chemistries (CH3, OH, COOH, NH2), we investigated the effects of surface chemistry on osteoblastic differentiation. We report that surface chemistry effectively modulates fibronectin adsorption, integrin binding, focal adhesion assembly and signaling to direct the osteoblast cellular functions of adhesion strength, gene expression and matrix mineralization. Specifically, surfaces presenting OH and NH2 functionalities provide enhanced functional presentation of adsorbed fibronectin, promoting specificity of integrin binding as well as elevating focal adhesion assembly and signaling. Furthermore, the OH and NH2 surfaces supported elevated levels of osteoblast differentiation as evidenced by osteoblast-specific gene expression and matrix mineralization. These results contribute to the development of design principles for the engineering of surfaces that direct cell adhesion for biomedical and tissue engineering applications. In particular, the understanding provided by this analysis may be useful in the engineering of surface properties for bone tissue repair and regeneration.

Author: Mitsuhiro Ebara
Publisher: Springer
ISBN: 4431544003
Category : Technology & Engineering
Languages : en
Pages : 380

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This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.

Author: Jeffrey O. Hollinger
Publisher: CRC Press
ISBN: 1135501912
Category : Medical
Languages : en
Pages : 500

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Book Description
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Author: Mario Barbosa
Publisher: Woodhead Publishing
ISBN: 008100852X
Category : Technology & Engineering
Languages : en
Pages : 392

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Book Description
Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. - Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration - Explores protein and peptides from the fundamentals, to processing and applications - Written by an international group of leading biomaterials researchers

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1666

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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Author: Júlio C. M. Souza
Publisher: Elsevier
ISBN: 0128146222
Category : Technology & Engineering
Languages : en
Pages : 238

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Book Description
Nanostructured Biomaterials for Cranio-maxillofacial and Oral Applications examines the combined impact of materials science, biomedical and chemical engineering, and biology to provide enhanced biomaterials for applications in maxillo-facial rehabilitation and implantology. With a strong focus on a variety of material classes, it examines material processing and characterization techniques to decrease mechanical and biological failure in the human body. After an introduction to the field, the most commonly used materials for cranio-facial applications, including ceramics, polymers and glass ceramics are presented. The book then looks at nanostructured surfaces, functionally graded biomaterials and the manufacturing of nanostructured materials via 3-D printing. This book is a valuable resource for scientists, researchers and clinicians wishing to broaden their knowledge in this important and developing field. - Explores the techniques used to apply nanotechnology to biomaterials for cranio-maxillofacial and oral applications - Bridges the gap between fundamental materials science and medicine - Shows how nanostructured biomaterials respond when implanted in the human body

Author: Peter A. Revell
Publisher: Woodhead Publishing
ISBN: 0128210834
Category : Technology & Engineering
Languages : en
Pages : 726

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Book Description
The third edition of Joint Replacement Technology provides a thoroughly updated review of recent developments in joint replacement technology. Joint replacement is a standard treatment for joint degradation and has improved the quality of life of millions of patients. Collaboration between clinicians and researchers is critical to its continued success and to meet the rising expectations of patients and surgeons.This edition covers a range of updated and new content, ranging from chapters on materials analysis and selection, to methodologies and techniques used for joint replacement and clinical challenges of replacing specific joints. Key topics include tribological considerations and experiments; challenges in joint bearing surfaces; cementless fixation techniques; healing responses to implants. Clinical challenges and perspectives are covered with the aid of case studies.Thanks to its widespread collaboration and international contributors, Joint Replacement Technology, Third Edition is useful for materials scientists and engineers in both academia and the biomedical industry. Chemists, clinicians, and other researchers in this area will also find this text invaluable. - This third edition provides an updated comprehensive review of recent developments in joint replacement technology - Reviews a range of specific joints, biological and mechanical issues and fixation techniques - Includes revised and new content, such as sections on regulatory affairs, AI techniques and 3D printing