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Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications

Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications PDF Author: Hai Yu Xu
Publisher: Frontiers Media SA
ISBN: 2832535518
Category : Science
Languages : en
Pages : 1019

Book Description
ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.

Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications

Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications PDF Author: Hai Yu Xu
Publisher: Frontiers Media SA
ISBN: 2832535518
Category : Science
Languages : en
Pages : 1019

Book Description
ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.

Integrative Pharmacology

Integrative Pharmacology PDF Author: Greg Sperber
Publisher:
ISBN: 9781891845697
Category : Integrative medicine
Languages : en
Pages : 479

Book Description


Integrated Pharmacology

Integrated Pharmacology PDF Author: Greg Sperber
Publisher: Blue Poppy Enterprises, Inc.
ISBN: 9781891845413
Category : Drug-herb interactions
Languages : en
Pages : 472

Book Description
Integrated Pharmacology: Combining Modern Pharmacology with Chinese Medicine, by Dr Greg Sperber, gives you basic information about each common class of Western pharmaceuticals. For each category of drug, Dr Sperber gives us the generic names, pronunciation, and registered proprietary versions, an explanation of function, mechanism of action, dosages for adults, children, and the elderly, possible adverse affects, red flags, and the most up-to-the-minute information on specific drug-drug and drug-herb interactions that may affect your patients. Additionally, the book includes commentary by Bob Flaws on a three-part system for evaluating Western meds using Chinese medical principles and a Chinese medical analysis of each class of drugs using this three-part system. This book has Over 130 illustrations showing the functions and mechanisms of each type of drug as well as a page-by-page glossary of potentially difficult terms throughout the book.

Polypharmacology

Polypharmacology PDF Author: Zhiguo Wang
Publisher: Springer Nature
ISBN: 3031049985
Category : Medical
Languages : en
Pages : 870

Book Description
There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.

Regenerative Pharmacology

Regenerative Pharmacology PDF Author: George J. Christ
Publisher: Cambridge University Press
ISBN: 1107354730
Category : Medical
Languages : en
Pages : 361

Book Description
Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.

Quantitative Pharmacology

Quantitative Pharmacology PDF Author: Johan Gabrielsson
Publisher:
ISBN: 9789197945233
Category : Pharmacokinetics
Languages : en
Pages : 263

Book Description


Regenerative Pharmacology

Regenerative Pharmacology PDF Author: George J. Christ
Publisher: Cambridge University Press
ISBN: 0521899494
Category : Medical
Languages : en
Pages : 361

Book Description
A state-of-the-art primer on the role of pharmacological sciences in regenerative medicine, for advanced students, postdoctoral fellows, and researchers.

Drug Repositioning: Current Advances and Future Perspectives

Drug Repositioning: Current Advances and Future Perspectives PDF Author: Yuhei Nishimura
Publisher: Frontiers Media SA
ISBN: 288945696X
Category :
Languages : en
Pages : 153

Book Description
Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine

Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine PDF Author: Aslam, Muhammad Shahzad
Publisher: IGI Global
ISBN: 1668494647
Category : Medical
Languages : en
Pages : 418

Book Description
The multidisciplinary applications of natural science in drug discovery are essential for identifying and developing new drugs and represent a promising area of research. Drug discovery is a complex and challenging process that involves multiple disciplines, including biology, chemistry, pharmacology, and medicine. One of the most interesting areas of drug discovery is using natural science, which involves the study of natural products and their potential therapeutic benefits, in which the research literature has previously been lacking appropriate attention. Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine is a research book that bridges the gap between traditional and natural science approaches to identify new drug molecules in treating various diseases. The book focuses on allopathic and complementary medicine. It takes a cross-disciplinary examination of biology, chemistry, pharmacology, mathematics, physics, and medicine. This book is suitable for researchers, post-doctoral fellows, graduate students, and post-graduate students interested in exploring natural science's multidisciplinary applications in drug discovery and integrative medicine.

Drug Discovery Toxicology

Drug Discovery Toxicology PDF Author: Yvonne Will
Publisher: John Wiley & Sons
ISBN: 1119053390
Category : Medical
Languages : en
Pages : 899

Book Description
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices