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Author: R. Michael Burger Publisher: Frontiers Media SA ISBN: 2889196674 Category : Auditory perception Languages : en Pages : 233
Book Description
There seems little doubt that from the earliest evolutionary beginnings, inhibition has been a fundamental feature of neuronal circuits - even the simplest life forms sense and interact with their environment, orienting or approaching positive stimuli while avoiding aversive stimuli. This requires internal signals that both drive and suppress behavior. Traditional descriptions of inhibition sometimes limit its role to the suppression of action potential generation. This view fails to capture the vast breadth of inhibitory function now known to exist in neural circuits. A modern perspective on inhibitory signaling comprises a multitude of mechanisms. For example, inhibition can act via a shunting mechanism to speed the membrane time constant and reduce synaptic integration time. It can act via G-protein coupled receptors to initiate second messenger cascades that influence synaptic strength. Inhibition contributes to rhythm generation and can even activate ion channels that mediate inward currents to drive action potential generation. Inhibition also appears to play a role in shaping the properties of neural circuitry over longer time scales. Experience-dependent synaptic plasticity in developing and mature neural circuits underlies behavioral memory and has been intensively studied over the past decade. At excitatory synapses, adjustments of synaptic efficacy are regulated predominantly by changes in the number and function of postsynaptic glutamate receptors. There is, however, increasing evidence for inhibitory modulation of target neuron excitability playing key roles in experience-dependent plasticity. One reason for our limited knowledge about plasticity at inhibitory synapses is that in most circuits, neurons receive convergent inputs from disparate sources. This problem can be overcome by investigating inhibitory circuits in a system with well-defined inhibitory nuclei and projections, each with a known computational function. Compared to other sensory systems, the auditory system has evolved a large number of subthalamic nuclei each devoted to processing distinct features of sound stimuli. This information once extracted is then re-assembled to form the percept the acoustic world around us. The well-understood function of many of these auditory nuclei has enhanced our understanding of inhibition's role in shaping their responses from easily distinguished inhibitory inputs. In particular, neurons devoted to processing the location of sound sources receive a complement of discrete inputs for which in vivo activity and function are well understood. Investigation of these areas has led to significant advances in understanding the development, physiology, and mechanistic underpinnings of inhibition that apply broadly to neuroscience. In this series of papers, we provide an authoritative resource for those interested in exploring the variety of inhibitory circuits and their function in auditory processing. We present original research and focused reviews touching on development, plasticity, anatomy, and evolution of inhibitory circuitry. We hope our readers will find these papers valuable and inspirational to their own research endeavors.
Author: R. Michael Burger Publisher: Frontiers Media SA ISBN: 2889196674 Category : Auditory perception Languages : en Pages : 233
Book Description
There seems little doubt that from the earliest evolutionary beginnings, inhibition has been a fundamental feature of neuronal circuits - even the simplest life forms sense and interact with their environment, orienting or approaching positive stimuli while avoiding aversive stimuli. This requires internal signals that both drive and suppress behavior. Traditional descriptions of inhibition sometimes limit its role to the suppression of action potential generation. This view fails to capture the vast breadth of inhibitory function now known to exist in neural circuits. A modern perspective on inhibitory signaling comprises a multitude of mechanisms. For example, inhibition can act via a shunting mechanism to speed the membrane time constant and reduce synaptic integration time. It can act via G-protein coupled receptors to initiate second messenger cascades that influence synaptic strength. Inhibition contributes to rhythm generation and can even activate ion channels that mediate inward currents to drive action potential generation. Inhibition also appears to play a role in shaping the properties of neural circuitry over longer time scales. Experience-dependent synaptic plasticity in developing and mature neural circuits underlies behavioral memory and has been intensively studied over the past decade. At excitatory synapses, adjustments of synaptic efficacy are regulated predominantly by changes in the number and function of postsynaptic glutamate receptors. There is, however, increasing evidence for inhibitory modulation of target neuron excitability playing key roles in experience-dependent plasticity. One reason for our limited knowledge about plasticity at inhibitory synapses is that in most circuits, neurons receive convergent inputs from disparate sources. This problem can be overcome by investigating inhibitory circuits in a system with well-defined inhibitory nuclei and projections, each with a known computational function. Compared to other sensory systems, the auditory system has evolved a large number of subthalamic nuclei each devoted to processing distinct features of sound stimuli. This information once extracted is then re-assembled to form the percept the acoustic world around us. The well-understood function of many of these auditory nuclei has enhanced our understanding of inhibition's role in shaping their responses from easily distinguished inhibitory inputs. In particular, neurons devoted to processing the location of sound sources receive a complement of discrete inputs for which in vivo activity and function are well understood. Investigation of these areas has led to significant advances in understanding the development, physiology, and mechanistic underpinnings of inhibition that apply broadly to neuroscience. In this series of papers, we provide an authoritative resource for those interested in exploring the variety of inhibitory circuits and their function in auditory processing. We present original research and focused reviews touching on development, plasticity, anatomy, and evolution of inhibitory circuitry. We hope our readers will find these papers valuable and inspirational to their own research endeavors.
Author: Jeffery A. Winer Publisher: Springer Science & Business Media ISBN: 1441900748 Category : Science Languages : en Pages : 711
Book Description
There has been substantial progress in understanding the contributions of the auditory forebrain to hearing, sound localization, communication, emotive behavior, and cognition. The Auditory Cortex covers the latest knowledge about the auditory forebrain, including the auditory cortex as well as the medial geniculate body in the thalamus. This book will cover all important aspects of the auditory forebrain organization and function, integrating the auditory thalamus and cortex into a smooth, coherent whole. Volume One covers basic auditory neuroscience. It complements The Auditory Cortex, Volume 2: Integrative Neuroscience, which takes a more applied/clinical perspective.
Author: Josef Syka Publisher: Springer Science & Business Media ISBN: 0387231811 Category : Medical Languages : en Pages : 404
Book Description
The symposium that has provided the basis for this book, "Plasticity of the Central Auditory System and Processing of Complex Acoustic Signals" was held in Prague on July 7-10, 2003. This is the fourth in a series of seminal meetings summarizing the state of development of auditory system neuroscience that has been organized in that great world city. Books that have resulted from these meetings represent important benchmarks for auditory neuroscience over the past 25 years. A 1980 meeting, "Neuronal Mechanisms of Hearing" hosted the most distinguished hearing researchers focusing on underlying brain processes from this era. It resulted in a highly influential and widely subscribed and cited proceedings co-edited by professor Lindsay Aitkin. The subject of the 1987 meeting was the "Auditory Pathway - Structure and Function". It again resulted in another important update of hearing science research in a widely referenced book - edited by the late Bruce Masterton. While the original plan was to hold a meeting summarizing the state of auditory system neuroscience every 7 years, historical events connected with the disintegration of the Soviet Empire and return of freedom to Czechoslovakia resulted in an unavoidable delay of what was planned to be a 1994 meeting. It wasn't until 1996 that we were able to meet for the third time in Prague, at that time to review "Acoustical Signal Processing in the Central Auditory System".
Author: Laurence O. Trussell Publisher: Springer Science & Business Media ISBN: 144199517X Category : Science Languages : en Pages : 242
Book Description
Synaptic Mechanisms in the Auditory System will provide a basic reference for students, clinicians, and researchers on how synapses in the auditory system function to encode acoustic signals. These mechanisms are the groundwork for all auditory processing, and understanding them requires knowledge of the microphysiology of synapses, cellular biophysics, receptor pharmacology, and an appreciation for what these synapses must do for a living, what unique jobs they carry out.
Author: Josue Yonge Publisher: American Medical Publishers ISBN: 9781639278992 Category : Medical Languages : en Pages : 0
Book Description
Auditory information processing refers to the capability of interpreting sounds heard by an individual. Central auditory processing plays an important role in recognizing incoming sounds, analyzing them and assigning meaning to them. It comprises steps related to information processing, which includes mechanical, electrical, chemical and central processing. The auditory system comprises the sensory organs, such as ears, as well as the auditory components of the sensory system. Excitatory neurons have a dominant function in the auditory cortex that transfers sensory information within and across brain areas. Inhibitory interneurons on the other hand, perform a variety of modulatory activities that determine how information is represented and processed. Inhibition has long been a characteristic of neuronal circuits. It helps to generate rhythms and is even capable of activating ion channels, which mediates an inward current that leads to the generation of action potentials. This book contains some path-breaking studies on auditory information processing. It will serve as a valuable source of reference for graduate and post graduate students. The readers would gain knowledge that would broaden their perspective about this area of study.
Author: Victoria Stenbäck Publisher: Linköping University Electronic Press ISBN: 9176856046 Category : Languages : en Pages : 72
Book Description
Age affects hearing and cognitive abilities. Older people, with and without hearing impairment (HI), exhibit difficulties in hearing speech in noise. Elderly individuals show greater difficulty in segregating target speech from distracting background noise, especially if the noise is competing speech with meaningful contents, so called informational maskers. Working memory capacity (WMC) has proven to be a crucial factor in comprehending speech in noise, especially for people with hearing loss. In auditory scenes where speech is disrupted by competing speech, high WMC has proven to facilitate the ability to segregate target speech and inhibit responses to irrelevant information. People with low WMC are more prone to be disrupted by competing speech and exhibit more difficulties in hearing target speech in complex listening environments. Furthermore, elderly individuals with a HI experience more difficulties in switching attention between wanted and irrelevant stimuli, and they employ more resources and time to attend to the stimuli than do normally - hearing (NH) younger adults. This thesis investigated the importance of inhibitory control and WMC for speech recognition in noise, and perceived listening effort. Four studies were conducted. In the first study, the aim was to develop a test of inhibitory control for verbal content, and to investigate the relation between inhibitory control and WMC, and how these two abilities related to speech recognition in noise, in young normally – hearing (YNH) individuals. In the second study we aimed to investigate the same relationship as in the first study to further strengthen the validity of the inhibitory test developed, as well as the importance of lexical access. It was also an aim to investigate the influence of age and hearing status on lexical access and WMC, and their respective roles for speech recognition in noise in both YNH and elderly HI (EHI) individuals. Study one and two showed that, for YNH, inhibitory control was related to speech recognition in noise, indicating that inhibitory control can help to predict speech recognition in noise performance. The relationship between WMC and speech recognition in noise in YNH shifted in the studies, suggesting that this relationship is multifaceted and varying. Lexical access was of little importance for YNH, although for EHI individuals, both WMC and lexical access was of importance for speech recognition in noise, suggesting that different cognitive abilities were of importance for the YNH and EHI individuals Study three investigated the relationship between inhibitory control, WMC, speech recognition in noise, and perceived listening effort, in YNH and elderly, for their age, NH, individuals (ENH). In study four the same relationships as in study three were investigated, albeit in EHI individuals. Two speech materials with different characteristics, masked with four background noises were used. The results in study three showed that less favourable SNRs were needed for informational maskers than for maskers without semantic content. ENH individuals were more susceptible to informational maskers than YNH individuals. In contrast, in study four, more favourable SNRs were needed for informational maskers. In both studies, results showed that speech recognition in noise performance differed depending on the characteristics of the speech material. The studies showed that high WMC, compared to low WMC, was beneficial for speech recognition in noise, especially for informational maskers, and resulted in lower ratings of perceived effort. Varying results were found in study three and four regarding perceived effort and inhibitory control. In study three good inhibitory control was associated with lower effort rating, while in study four, individuals with a HI and good inhibitory control rated effort as higher. The results suggest that hearing status, age, and cognitive abilities, contribute to the differences in performance between YNH, ENH, and EHI individuals in speech – recognition – in – noise - and cognitive tasks. This thesis has, for the first time, demonstrated that a measure of inhibitory control of verbal content, is related to speech recognition in noise performance in YNH, ENH and EHI individuals. Results presented in this thesis also show that both WMC and inhibitory control are related to an individuals’ perception of how effortful a listening task is. It also adds to the literature that WMC is related to speech recognition in noise performance for ENH and EHI individuals, but that this relationship is not as robust in YNH individuals.
Author: R. Michael Burger
Author: R. Michael Burger
Author: Jeffery A. Winer
Author: R. Michael Burger
Author: Josef Syka
Author: Raphael Pinaud
Author: Laurence O. Trussell
Author: Jack Katz
Author: Josue Yonge
Author: Weimin Zheng
Author: Victoria Stenbäck