Inhaled Nitric Oxide in Pulmonary Hypertension in Children PDF Download

Author: Maila Turanlahti
Publisher:
ISBN: 9789529126385
Category :
Languages : en
Pages : 73

View

Book Description

Author: Jaroslav F. Stark
Publisher: John Wiley & Sons
ISBN: 047009317X
Category : Medical
Languages : en
Pages : 754

View

Book Description
Over 10 years after the publication of the second edition, Wiley now publishes the third edition of the popular volume Surgery for Congenital Heart Defects. Completely updated and expanded, this new edition describes step-by-step the surgical procedures for congenital heart defects and includes detailed illustrations for each operation. New in this edition are chapters on exercise testing, MRI, EP studies and catheter ablation of arrhythmias, extracorporeal circulatory support and paediatric lung transplantation. A greatly expanded ultrasound chapter contains numerous colour Doppler’s of many conditions. Surgery for Congenital Heart Defects, Third Edition: Provides complete coverage of the current issues in paediatric cardiac surgery Offers tips and surgical techniques to master difficult surgical situations Uniquely displays detailed illustrations for each operation, allowing surgeons to follow all operating procedures step-by-step Serves both as reference and training manual

Author: Toshio Nakanishi
Publisher: Springer Nature
ISBN: 9811511853
Category : Medical
Languages : en
Pages : 374

View

Book Description
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Author: Eduardo da Cruz
Publisher: Springer
ISBN: 9781447146186
Category : Medical
Languages : en
Pages : 3572

View

Book Description
Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care provides a consistent and comprehensive approach to multiple congenital and acquired cardiac pathologies pre, peri and postoperatively, with the use of algorhythms, guidelines and current research issues. Included with the e-reference are interactive videos with the most common interventions, online access to practical learning activities, and to the comprehensive Aristotle score and database. This reference work satisfies the need for a universal and practical review of management of critically ill children and adults with congenital heart disease, based upon taskforce decisions and the cumulative experience of the world leaders in the field.

Author: N. Y. Boo
Publisher:
ISBN:
Category :
Languages : en
Pages :

View

Book Description

Author: Sandra Benavides
Publisher:
ISBN: 9781932658897
Category : Medical
Languages : en
Pages : 909

View

Book Description

Author: U. S. Department of Health and Human Services
Publisher: Createspace Independent Pub
ISBN: 9781484934616
Category : Medical
Languages : en
Pages : 310

View

Book Description
Neonatal lung disease is the most common complication of preterm delivery, and results in significant morbidity and mortality. Preterm infants suffer from both acute and chronic respiratory failure as a result of anatomic and biochemical disruption of lung function, lung inflammation and oxidative stress, nutritional deficiencies, and arrest of tracheobronchial and pulmonary vascular growth. Treatment for acute respiratory failure often contributes to evolving bronchopulmonary dysplasia (BPD) and chronic respiratory failure, due to barotrauma and oxygen toxicity from prolonged respiratory support, deficient nutrition, as well as immaturity of lung growth, vascular development and immunologic defenses. Pulmonary hypertension may occur in association with acute and/or chronic respiratory failure. Multiple etiologies make finding an effective treatment for respiratory failure in preterm infants challenging. Disorders related to prematurity and respiratory distress are among the leading causes of infant mortality in the U.S. Treatment options for respiratory failure in preterm infants include a variety of modalities. Prenatal steroids, antibiotics, exogenous surfactant replacement, tidal volume ventilation, conventional ventilation, continuous positive airway pressure, high flow oxygen administration, and high frequency ventilation are all used as therapeutic modalities. Treatment of preterm infants with inhaled nitric oxide (iNO) as a rescue therapy for refractory hypoxemic respiratory failure is an extension of the relative success of the treatment of term and near term infants with iNO. Inhaled NO has demonstrated efficacy in improving oxygenation and reducing the need for extracorporeal membrane oxygenation (ECMO) in late preterm infants born after 34 weeks gestation and full term infants with respiratory failure, with no evidence of long term benefits. Despite the approved use of iNO in full term and late preterm infants, the developmentally distinct mechanisms of respiratory failure and differing cardiovascular, pulmonary, and pharmacokinetic characteristics of more immature infants require systematic study of the short and long term outcomes for preterm infants treated with iNO to prevent or treat respiratory failure. The Cochrane review acknowledged very limited data on long term outcomes of preterm infants treated with iNO. If iNO is beneficial, the number need to treat would be very large. Papers published or presented from 2007 to present report conflicting results as to whether, in preterm infants, iNO has beneficial, adverse, or no effects on long term neurodevelopmental and pulmonary outcomes. Despite the ongoing controversy, iNO continues to be used for hypoxemic respiratory failure in preterm infants less than 34 weeks gestation even with potential harm to the developing lungs and brain. There is an urgent need to weigh the current evidence as to whether iNO is a safe and effective treatment in preterm infants. We sought to identify and synthesize evidence addressing the following questions: 1. Does inhaled nitric oxide (iNO) therapy increase survival and/or reduce the occurrence or severity of bronchopulmonary dysplasia (BPD) among premature infants who receive respiratory support? 2. Are there short term risks of iNO therapy among premature infants who receive respiratory support? 3. Are there effects of iNO therapy on long term pulmonary and/or neurodevelopmental outcomes among premature infants who receive respiratory support? 4. Does the effect of iNO therapy on BPD and/or death or neurodevelopmental impairment vary across subpopulations of premature infants? 5. Does the effect of iNO therapy on BPD and/or death or neurodevelopmental impairment vary by timing of initiation, mode of delivery, dose and duration, or concurrent therapies?

Author: Abialbon Paul
Publisher: Springer Nature
ISBN: 9813360097
Category : Medical
Languages : en
Pages : 1156

View

Book Description
This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Author: Henry C. Lee
Publisher:
ISBN: 9781610023986
Category : Medical
Languages : en
Pages : 0

View

Book Description
Enhance your knowledge of neonatal-perinatal medicine and/or study for Neonatal-Perinatal Medicine board certification or recertification with this new study guide from the editors of NeoReviews. This new guide includes more than 1,200 questions previously published in NeoReviews from January 2007 to December 2017. Each question is followed by a short explanation of the correct answer with references, including the original article. Chapters include Cardiology Dermatology Endocrinology ENT and Ophthalmology Fluids, Electrolytes, Nutrition Gastrointestinal Genetics and Inborn Errors of Metabolism Hematology/Oncology Immunology Infectious Diseases Maternal-Fetal Medicine Neonatal Resuscitation Neurology Renal Respiratory Statistics, Research, Health Services, and Ethics

Author: Steven L. Shein
Publisher: Springer Nature
ISBN: 3030218406
Category : Medical
Languages : en
Pages : 231

View

Book Description
This book provides a concise yet comprehensive overview of pediatric acute respiratory distress syndrome (PARDS). The text reviews the emerging science behind the new PARDS definition; explores epidemiology, pathobiology, etiologies, and risk factors; reviews state-of-the-art treatment modalities and strategies; and discusses clinical outcomes. Written by experts in the field, Pediatric Acute Respiratory Distress Syndrome: A Clinical Guide is a valuable resource for clinicians and practitioners who specialize in pediatric critical care.