Inhaled Nitric Oxide and Intravenous Magnesium Suphate for the Treatment of Persistent Pulmonary Hypertension of the Newborn PDF Download

Author: N. Y. Boo
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author:
Publisher: ScholarlyEditions
ISBN: 1464904049
Category : Medical
Languages : en
Pages : 98

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Book Description
Pulmonary Hypertension: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Pulmonary Hypertension in a concise format. The editors have built Pulmonary Hypertension: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pulmonary Hypertension in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pulmonary Hypertension: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author: U. S. Department of Health and Human Services
Publisher: Createspace Independent Pub
ISBN: 9781484934616
Category : Medical
Languages : en
Pages : 310

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Neonatal lung disease is the most common complication of preterm delivery, and results in significant morbidity and mortality. Preterm infants suffer from both acute and chronic respiratory failure as a result of anatomic and biochemical disruption of lung function, lung inflammation and oxidative stress, nutritional deficiencies, and arrest of tracheobronchial and pulmonary vascular growth. Treatment for acute respiratory failure often contributes to evolving bronchopulmonary dysplasia (BPD) and chronic respiratory failure, due to barotrauma and oxygen toxicity from prolonged respiratory support, deficient nutrition, as well as immaturity of lung growth, vascular development and immunologic defenses. Pulmonary hypertension may occur in association with acute and/or chronic respiratory failure. Multiple etiologies make finding an effective treatment for respiratory failure in preterm infants challenging. Disorders related to prematurity and respiratory distress are among the leading causes of infant mortality in the U.S. Treatment options for respiratory failure in preterm infants include a variety of modalities. Prenatal steroids, antibiotics, exogenous surfactant replacement, tidal volume ventilation, conventional ventilation, continuous positive airway pressure, high flow oxygen administration, and high frequency ventilation are all used as therapeutic modalities. Treatment of preterm infants with inhaled nitric oxide (iNO) as a rescue therapy for refractory hypoxemic respiratory failure is an extension of the relative success of the treatment of term and near term infants with iNO. Inhaled NO has demonstrated efficacy in improving oxygenation and reducing the need for extracorporeal membrane oxygenation (ECMO) in late preterm infants born after 34 weeks gestation and full term infants with respiratory failure, with no evidence of long term benefits. Despite the approved use of iNO in full term and late preterm infants, the developmentally distinct mechanisms of respiratory failure and differing cardiovascular, pulmonary, and pharmacokinetic characteristics of more immature infants require systematic study of the short and long term outcomes for preterm infants treated with iNO to prevent or treat respiratory failure. The Cochrane review acknowledged very limited data on long term outcomes of preterm infants treated with iNO. If iNO is beneficial, the number need to treat would be very large. Papers published or presented from 2007 to present report conflicting results as to whether, in preterm infants, iNO has beneficial, adverse, or no effects on long term neurodevelopmental and pulmonary outcomes. Despite the ongoing controversy, iNO continues to be used for hypoxemic respiratory failure in preterm infants less than 34 weeks gestation even with potential harm to the developing lungs and brain. There is an urgent need to weigh the current evidence as to whether iNO is a safe and effective treatment in preterm infants. We sought to identify and synthesize evidence addressing the following questions: 1. Does inhaled nitric oxide (iNO) therapy increase survival and/or reduce the occurrence or severity of bronchopulmonary dysplasia (BPD) among premature infants who receive respiratory support? 2. Are there short term risks of iNO therapy among premature infants who receive respiratory support? 3. Are there effects of iNO therapy on long term pulmonary and/or neurodevelopmental outcomes among premature infants who receive respiratory support? 4. Does the effect of iNO therapy on BPD and/or death or neurodevelopmental impairment vary across subpopulations of premature infants? 5. Does the effect of iNO therapy on BPD and/or death or neurodevelopmental impairment vary by timing of initiation, mode of delivery, dose and duration, or concurrent therapies?

Author: Corinna Mirjam Gebauer
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Background and aims: Inhaled nitric oxide (iNO) is an approved therapy for neonates with mechanical ventilation for hypoxic respiratory failure (HRF). Little is known about the early non-invasive iNO treatment of persistent pulmonary hypertension (PPH) via nasal cannula or mask. We studied this practice in spontaneously breathing term and preterm infants, hypothesizing that it would be associated with reduced oxygen requirements.Methods: In our electronic medical records (2011 to 2017) we identified 123 inborn neonates receiving iNO. Whereof 46 singletons with PPH were exclusively spontaneously breathing on respiratory support via nasal continuous positive airway pressure (CPAP) receiving non-invasive iNO treatment starting within their first 12 hours of life. In all infants HRF (persistent supplemental oxygen >30%) was accompanied by echocardiographically proven PPH. Results: 46 neonates receiving non-invasive iNO were studied with a median birth weight of 2629g (740g u2013 4680g) and a median gestational age of 35 weeks (24+6 weeks u2013 41+6 weeks) including 10 preterm infants u2264 30 weeks. Median duration of non-invasive iNO application was 24 hours (1,5 hours u2013 168 hours) with a mean starting dose of 20 ppm. Fractional oxygen requirements dropped with initiation of non-invasive iNO from median 60% to 25% (p

Author: Elaine M. Boyle
Publisher: Springer Nature
ISBN: 3030288293
Category : Medical
Languages : en
Pages : 575

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This textbook addresses the themes that are at the forefront of neonatal clinical care and research, based on natural divisions in care during pregnancy, and postnatally by gestational age at birth. The book offers a unique approach, in that it proposes discussion of important general principles underpinning neonatal care that are not addressed in most general neonatology textbooks, such as ethical issues, counselling, effective training methods, quality and safety, among other subjects. These are fundamental aspects and challenges that need to be appreciated by senior clinicians. A chapter authored by parents describing their perspectives of neonatal intensive care is unique and will be highly educational, with the potential to influence the way in which individuals view and deliver neonatal care. The authors discuss common and important conditions, to promote adoption of sound evidenced based practice where this is available. However, where evidence is limited, as is the case in many areas of neonatal practice, the authors aim to encourage critical thinking and evidence appraisal, which are necessary skills for busy clinicians wishing to filter evidence to guide delivery of care. This text is suitable for senior trainees wishing to pursue a career in neonatal medicine, early career neonatologists and paediatricians with an interest in neonatology. It is also of interest to established neonatologists wishing to update their neonatal knowledge. The content is based on the RCPCH Level 3 curriculum, and addresses important topical and/or controversial aspects of neonatal care.

Author: Jennifer Billerbeck
Publisher:
ISBN:
Category : Persistent fetal circulation syndrome
Languages : en
Pages : 0

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Author: Istvan Seri
Publisher: Elsevier Health Sciences
ISBN: 0323568432
Category : Medical
Languages : en
Pages : 635

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Dr. Richard Polin's Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. - Stay fully up to date in this fast-changing field with Hemodynamics and Cardiology, 3rd Edition. - A new editorial team and a completely redesigned volume with state-of-the-art chapters on neonatal hemodynamics. - New chapters on the role of delayed cord clamping/cord milking, the relationship between neonatal transition and brain injury, the hemodynamics of the asphyxiated neonate, the hemodynamic impact of therapeutic hypothermia, and practical physiology-based approaches to the diagnosis and treatment of neonatal hypotension, PPHN and PDA. - A new section discusses comprehensive real-time monitoring of neonatal hemodynamics, and its role in the establishment of precision medicine in neonatology and the prediction of neonatal sepsis using mathematical modelling of heart rate variability. - Expanded sections review the clinical application of the tools available for bedside monitoring of systemic and organ blood flow and oxygen delivery and the approaches to the pathophysiology-based treatment of neonatal shock and outcomes. - Consistent chapter organization to help you find information quickly and easily. - The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set!Gastroenterology and NutritionHematology, Immunology and GeneticsHemodynamics and CardiologyInfectious Disease and Pharmacology New Volume!Nephrology and Fluid/Electrolyte PhysiologyNeurologyThe Newborn Lung

Author: Amar A Sholapurkar
Publisher: JP Medical Ltd
ISBN: 9350253461
Category : Medical
Languages : en
Pages : 473

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Publish and Flourish provides concise, comprehensive advice on how to write a scientific paper. Beginning with a basic introduction, this reference guides professionals step by step through the core skills necessary for the preparation of an original research paper, review articles and case reports. The principles can be applied to all disciplines of health sciences and this text offers practical advice with illustrated examples to help medical writers achieve publication in good journals.

Author: Jay P. Goldsmith
Publisher: Elsevier Health Sciences
ISBN: 143773586X
Category : Medical
Languages : en
Pages : 658

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Assisted Ventilation of the Neonate, 5th Edition, by Drs. Jay P. Goldsmith and Edward Karotkin, guides you through the latest innovations in ventilatory assistance, helping you improve outcomes and quality of life in newborns. With a new emphasis on non-invasive ventilation and earlier extubation, it covers basic concepts of pulmonary pathophysiology and offers practical guidance on both basic and advanced ventilation management strategies. Access expert coverage of all aspects of neonatal pulmonary care—including complications, nutrition, transport, outcomes, follow-up, and parental education. Sharpen your diagnostic and clinical skills with case studies drawn from actual patients. Find key facts fast with more than 30 quick-reference appendices: normal values, assessment charts, ICU flow charts, procedure steps, and other useful tools. Learn how to best use assisted ventilation equipment and pharmacologic agents to prevent long-term pulmonary and neurologic damage. Benefit from Drs. Goldsmith and Karotkin’s widely acknowledged expertise in neonatology and pulmonology. Incorporate the latest innovations in ventilatory strategies in your practice. Gain new insight into today’s hottest topics including Ventilator Associated Pneumonia; Quality Improvement; Ventilation of Neonates in Developing Countries; and Human Interactions with Mechanical Ventilators. Understand the pros and cons of non-invasive ventilation and earlier extubation. Avoid ventilator-associated illness and injury with practical guidance in this vital area. Get coverage of basic concepts and advanced neonatal ventilation management strategies in one volume. Master the art of mechanical ventilation with the latest innovations in ventilatory assistance and improve outcomes and quality of life in newborns.

Author: Sean B. Ainsworth
Publisher: John Wiley & Sons
ISBN: 1118819519
Category : Medical
Languages : en
Pages : 647

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Book Description
Neonatal Formulary is a unique publication that provides comprehensive guidance on the safe use of all the drugs prescribed during pregnancy and commonly given to babies during labour, delivery, and the first year of life. This new edition provides improved and detailed coverage of the many drugs that are given to women during pregnancy and during lactation where the baby's welfare must be borne in mind as well as that of the mother. Thus the whole 'pregnancy through to parenthood' journey is treated as a continuous event with information about drug use and the effects of drugs at all stages of the development from fetus to infant. Containing far more detail than is available in the British National Formulary for Children and with a companion website featuring updates related to specific drugs and dosing, Neonatal Formulary is an essential guide for neonatologists, neonatal nurses, hospital pharmacists, obstetric staff, advanced nurse practitioners and for all health care professionals caring for pregnant women and their infants in the first year of life. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.