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Author: Kwakye Peprah Publisher: ISBN: Category : Languages : en Pages : 25
Book Description
Cystic fibrosis (CF) is a rare chronic genetic disease that affects multiple systems in the body including the respiratory tract, pancreas, gastro-intestinal tract and liver. The disorder is caused by mutations of the CF transmembrane conductance regulator (CFTR) gene. Approximately, one in 25 Canadians carries an abnormal CFTR gene, and CF occurs in children who inherit two abnormal genes, one from each parent. It is estimated that one in every 3,600 children born in Canada has CF, with more than 4,300 Canadian children, adolescents, and adults with CF attending specialized CF clinics. The disease has no cure at present, and it is the most common fatal genetic disease affecting Canadian children and young adults. Lung disease is the most prominent manifestation of CF, and it is reported to account for nearly 85% of deaths. Respiratory tract abnormalities in CF patients cause mucus plugging of the airways, bronchial wall thickening due to inflammation, increased susceptibility to respiratory tract infection, and airway destruction. Much of the pulmonary damage begins with lung inflammation. Although a normal inflammatory response is beneficial to host defence mechanisms, and helps to prevent the spread of infection, the excessive inflammation seen in CF patients is harmful as it contributes to the disease and associated death. One of the goals in the treatment of cystic fibrosis is to reduce lung inflammation. Corticosteroids are potent anti-inflammatory drugs which have been widely used in the treatment of a variety of diseases with underlying inflammation including asthma and chronic obstructive pulmonary disease (COPD). They exert direct inhibitory effects on many inflammatory cells, and regular use of inhaled corticosteroids (ICS) has been reported to reduce the number of mast cells within the airways, decrease airway microvascular leakage, and lessen mucus production. Although benefit of its use in CF has not been proven, ICS has been widely prescribed as anti-inflammatory agents to treat children and adults with CF empirically. The objective of this report is to summarize the evidence regarding the clinical effectiveness of ICS for the treatment of CF.
Author: Kwakye Peprah Publisher: ISBN: Category : Languages : en Pages : 25
Book Description
Cystic fibrosis (CF) is a rare chronic genetic disease that affects multiple systems in the body including the respiratory tract, pancreas, gastro-intestinal tract and liver. The disorder is caused by mutations of the CF transmembrane conductance regulator (CFTR) gene. Approximately, one in 25 Canadians carries an abnormal CFTR gene, and CF occurs in children who inherit two abnormal genes, one from each parent. It is estimated that one in every 3,600 children born in Canada has CF, with more than 4,300 Canadian children, adolescents, and adults with CF attending specialized CF clinics. The disease has no cure at present, and it is the most common fatal genetic disease affecting Canadian children and young adults. Lung disease is the most prominent manifestation of CF, and it is reported to account for nearly 85% of deaths. Respiratory tract abnormalities in CF patients cause mucus plugging of the airways, bronchial wall thickening due to inflammation, increased susceptibility to respiratory tract infection, and airway destruction. Much of the pulmonary damage begins with lung inflammation. Although a normal inflammatory response is beneficial to host defence mechanisms, and helps to prevent the spread of infection, the excessive inflammation seen in CF patients is harmful as it contributes to the disease and associated death. One of the goals in the treatment of cystic fibrosis is to reduce lung inflammation. Corticosteroids are potent anti-inflammatory drugs which have been widely used in the treatment of a variety of diseases with underlying inflammation including asthma and chronic obstructive pulmonary disease (COPD). They exert direct inhibitory effects on many inflammatory cells, and regular use of inhaled corticosteroids (ICS) has been reported to reduce the number of mast cells within the airways, decrease airway microvascular leakage, and lessen mucus production. Although benefit of its use in CF has not been proven, ICS has been widely prescribed as anti-inflammatory agents to treat children and adults with CF empirically. The objective of this report is to summarize the evidence regarding the clinical effectiveness of ICS for the treatment of CF.
Author: A. Roberto Frisancho Publisher: University of Michigan Press ISBN: 9780472101467 Category : Health & Fitness Languages : en Pages : 220
Book Description
This book presents: the theoretical rationale for use as an evaluation of nutritional status; techniques for data collection; statistical basis for classifying individuals or populations; standards; reference data for blacks and whites; and graphs that facilitate the interpretation of the data.
Author: Bruce K. Rubin Publisher: Springer Science & Business Media ISBN: 9783764359256 Category : Medical Languages : en Pages : 300
Book Description
Although the potential for immunomodulation has been recognized for many years there has been an explosion of data in this field with relevance especially to the treatment of chronic airway diseases. Most of the work in this field has been conducted by Japanese investigators but in the last decade there has been a body of work outside of Japan that supports and enhances these findings. The book covers basic research like effects on bacteria, anti-inflammatory and mucoregulatory effects, but also clinical results with up-to-date information for the use of such medications to potentially treat diseases as diverse as chronic airway diseases, arthritis, inflammatory bowel disease, and cancer. The volume is intended for pulmonary physicians, researchers in inflammation research, and pharmaceutical companies interested in the development of such agents. It provides background information for the clinician as well as in depth exploration of cutting edge science.
Author: Allison D. Fryer Publisher: Springer Science & Business Media ISBN: 3642232744 Category : Medical Languages : en Pages : 501
Book Description
Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.
Author: Venkataramana K Sidhaye Publisher: Academic Press ISBN: 0128038810 Category : Medical Languages : en Pages : 277
Book Description
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences
Author: Mieczyslaw Pokorski Publisher: Springer ISBN: 3319100122 Category : Medical Languages : en Pages : 74
Book Description
The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.
Author: Prashant Mohite Publisher: BoD – Books on Demand ISBN: 1838810730 Category : Medical Languages : en Pages : 126
Book Description
Cystic fibrosis, a genetic disorder in children and young adults, is a multisystemic disease that mainly affects the lungs. Advances and improvements in the diagnosis and management of this condition have led to increased overall and symptom-free survival in cystic fibrosis patients. This book examines recent advances in the field and presents an evidence-based approach to the management of cystic fibrosis.
Author: Sics Editore Publisher: SICS Editore ISBN: 8869309584 Category : Medical Languages : en Pages : 39
Book Description
Cystic fibrosis (CF) is a hereditary metabolic disease. Its main symptoms include progressive pulmonary symptoms in the childhood and exocrine insufficiency of the pancreas, which leads to chronic steatorrhoea. Diagnosis is based on the measurement of chloride concentration in the sweat. The test can be supplemented with the investigation of gene mutations.
Author: D.H. Parikh Publisher: Springer Science & Business Media ISBN: 1848009038 Category : Medical Languages : en Pages : 593
Book Description
This text covers new innovations and concepts in pediatric thoracic surgery practice, basic science and evidence, and the technical aspects of common and rare operative procedures. It is essential for pediatric surgical trainees and consultants with interest in pediatric thoracic surgery. Providing comprehensive coverage of newer developments, it is also a useful reference work for pediatric and thoracic surgeons and a valuable guide for surgeons (adult or pediatric) managing pediatric thoracic surgery on occasional basis or only during acute emergency.Covering the subjects within pediatric thoracic surgery (non-cardiac) in significant depth, this book acts as a reference text for consultants undertaking pediatric thoracic work as well as for pediatric respiratory, anesthetists and fetal medicine doctors. Topics within this book will also be of interest to pediatric respiratory physicians and pediatric oncologists.
Author: Kwakye Peprah
Author: Kwakye Peprah
Author: A. Roberto Frisancho
Author: Bruce K. Rubin
Author: Allison D. Fryer
Author: Venkataramana K Sidhaye
Author: Mieczyslaw Pokorski
Author: Prashant Mohite
Author: Sics Editore
Author: S. Karger AG
Author: D.H. Parikh