Information Theory and Molecular Biology PDF Download

Author: Hubert P. Yockey
Publisher: Cambridge University Press
ISBN: 9780521359030
Category : Science
Languages : en
Pages : 408

View

Book Description
Dr. Yockey presents an introduction to the use of information theory in molecular biology. The book lends to molecular biology a well-developed mathematical foundation and provides mathematical definitions for the vocabulary with which basic questions in molecular biology are debated: information, complexity, order, uncertainty, randomness, and similarity.

Author: Hubert P. Yockey
Publisher: Cambridge University Press
ISBN: 9780521802932
Category : Language Arts & Disciplines
Languages : en
Pages : 276

View

Book Description
Publisher Description

Author: John Scales Avery
Publisher: World Scientific
ISBN: 9811250383
Category : Science
Languages : en
Pages : 329

View

Book Description
This highly interdisciplinary book discusses the phenomenon of life, including its origin and evolution, against the background of thermodynamics, statistical mechanics, and information theory. Among the central themes is the seeming contradiction between the second law of thermodynamics and the high degree of order and complexity produced by living systems. As the author shows, this paradox has its resolution in the information content of the Gibbs free energy that enters the biosphere from outside sources. Another focus of the book is the role of information in human cultural evolution, which is also discussed with the origin of human linguistic abilities. One of the final chapters addresses the merging of information technology and biotechnology into a new discipline — bioinformation technology.This third edition has been updated to reflect the latest scientific and technological advances. Professor Avery makes use of the perspectives of famous scholars such as Professor Noam Chomsky and Nobel Laureates John O'Keefe, May-Britt Moser and Edward Moser to cast light on the evolution of human languages. The mechanism of cell differentiation, and the rapid acceleration of information technology in the 21st century are also discussed.With various research disciplines becoming increasingly interrelated today, Information Theory and Evolution provides nuance to the conversation between bioinformatics, information technology, and pertinent social-political issues. This book is a welcome voice in working on the future challenges that humanity will face as a result of scientific and technological progress.

Author: Roman F Nalewajski
Publisher: Elsevier
ISBN: 0080459749
Category : Science
Languages : en
Pages : 463

View

Book Description
As well as providing a unified outlook on physics, Information Theory (IT) has numerous applications in chemistry and biology owing to its ability to provide a measure of the entropy/information contained within probability distributions and criteria of their information "distance" (similarity) and independence. Information Theory of Molecular Systems applies standard IT to classical problems in the theory of electronic structure and chemical reactivity. The book starts by introducing the basic concepts of modern electronic structure/reactivity theory based upon the Density Functional Theory (DFT), followed by an outline of the main ideas and techniques of IT, including several illustrative applications to molecular systems. Coverage includes information origins of the chemical bond, unbiased definition of molecular fragments, adequate entropic measures of their internal (intra-fragment) and external (inter-fragment) bond-orders and valence-numbers, descriptors of their chemical reactivity, and information criteria of their similarity and independence. Information Theory of Molecular Systems is recommended to graduate students and researchers interested in fresh ideas in the theory of electronic structure and chemical reactivity. ·Provides powerful tools for tackling both classical and new problems in the theory of the molecular electronic structure and chemical reactivity·Introduces basic concepts of the modern electronic structure/reactivity theory based upon the Density Functional Theory (DFT)·Outlines main ideas and techniques of Information Theory

Author: Martin Bossert
Publisher: Springer
ISBN: 3319547291
Category : Technology & Engineering
Languages : en
Pages : 374

View

Book Description
This edited monograph presents the collected interdisciplinary research results of the priority program “Information- and Communication Theory in Molecular Biology (InKoMBio, SPP 1395)”, funded by the German Research Foundation DFG, 2010 until 2016. The topical spectrum is very broad and comprises, but is not limited to, aspects such as microRNA as part of cell communication, information flow in mammalian signal transduction pathway, cell-cell communication, semiotic structures in biological systems, as well as application of methods from information theory in protein interaction analysis. The target audience primarily comprises research experts in the field of biological signal processing, but the book is also beneficial for graduate students alike.

Author: Christoph Adami
Publisher: Princeton University Press
ISBN: 0691241155
Category : Science
Languages : en
Pages : 585

View

Book Description
Why information is the unifying principle that allows us to understand the evolution of complexity in nature More than 150 years after Darwin’s revolutionary On the Origin of Species, we are still attempting to understand and explain the amazing complexity of life. Although we now know how evolution proceeds to build complexity from simple ingredients, quantifying this complexity is still a difficult undertaking. In this book, Christoph Adami offers a new perspective on Darwinian evolution by viewing it through the lens of information theory. This novel theoretical stance sheds light on such matters as how viruses evolve drug resistance, how cells evolve to communicate, and how intelligence evolves. By this account, information emerges as the central unifying principle behind all of biology, allowing us to think about the origin of life—on Earth and elsewhere—in a systematic manner. Adami, a leader in the field of computational biology, first provides an accessible introduction to the information theory of biomolecules and then shows how to apply these tools to measure information stored in genetic sequences and proteins. After outlining the experimental evidence of the evolution of information in both bacteria and digital organisms, he describes the evolution of robustness in viruses; the cooperation among cells, animals, and people; and the evolution of brains and intelligence. Building on extensive prior work in bacterial and digital evolution, Adami establishes that (expanding on Dobzhansky’s famous remark) nothing in biology makes sense except in the light of information. Understanding that information is the foundation of all life, he argues, allows us to see beyond the particulars of our way of life to glimpse what life might be like in other worlds.

Author: Henry Quastler
Publisher:
ISBN:
Category : Biology
Languages : en
Pages : 298

View

Book Description

Author: Lily E. Kay
Publisher: Stanford University Press
ISBN: 9780804734172
Category : Science
Languages : en
Pages : 476

View

Book Description
This is a detailed history of one of the most important and dramatic episodes in modern science, recounted from the novel vantage point of the dawn of the information age and its impact on representations of nature, heredity, and society. Drawing on archives, published sources, and interviews, the author situates work on the genetic code (1953-70) within the history of life science, the rise of communication technosciences (cybernetics, information theory, and computers), the intersection of molecular biology with cryptanalysis and linguistics, and the social history of postwar Europe and the United States. Kay draws out the historical specificity in the process by which the central biological problem of DNA-based protein synthesis came to be metaphorically represented as an information code and a writing technology—and consequently as a “book of life.” This molecular writing and reading is part of the cultural production of the Nuclear Age, its power amplified by the centuries-old theistic resonance of the “book of life” metaphor. Yet, as the author points out, these are just metaphors: analogies, not ontologies. Necessary and productive as they have been, they have their epistemological limitations. Deploying analyses of language, cryptology, and information theory, the author persuasively argues that, technically speaking, the genetic code is not a code, DNA is not a language, and the genome is not an information system (objections voiced by experts as early as the 1950s). Thus her historical reconstruction and analyses also serve as a critique of the new genomic biopower. Genomic textuality has become a fact of life, a metaphor literalized, she claims, as human genome projects promise new levels of control over life through the meta-level of information: control of the word (the DNA sequences) and its editing and rewriting. But the author shows how the humbling limits of these scriptural metaphors also pose a challenge to the textual and material mastery of the genomic “book of life.”

Author: Robert J Marks II
Publisher: World Scientific Publishing Company
ISBN: 9814508721
Category : Computers
Languages : en
Pages : 584

View

Book Description
In the spring of 2011, a diverse group of scientists gathered at Cornell University to discuss their research into the nature and origin of biological information. This symposium brought together experts in information theory, computer science, numerical simulation, thermodynamics, evolutionary theory, whole organism biology, developmental biology, molecular biology, genetics, physics, biophysics, mathematics, and linguistics. This volume presents new research by those invited to speak at the conference. The contributors to this volume use their wide-ranging expertise in the area of biological information to bring fresh insights into the many explanatory difficulties associated with biological information. These authors raise major challenges to the conventional scientific wisdom, which attempts to explain all biological information exclusively in terms of the standard mutation/selection paradigm. Several clear themes emerged from these research papers: 1) Information is indispensable to our understanding of what life is; 2) Biological information is more than the material structures that embody it; 3) Conventional chemical and evolutionary mechanisms seem insufficient to fully explain the labyrinth of information that is life. By exploring new perspectives on biological information, this volume seeks to expand, encourage, and enrich research into the nature and origin of biological information.

Author: Terrell L. Hill
Publisher: Springer Science & Business Media
ISBN: 1461247365
Category : Science
Languages : en
Pages : 317

View

Book Description
During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known ofthe chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis oflife is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breathtaking insights into the molecular mechanisms used by nature for replicating, distributing, and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromo lecular nucleic acids and proteins, and the manner in which carbohydrates, lipids, and smaller molecules work together to provide the molecular setting ofliving systems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context ofthis flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective-what is known about the field today-and a descrip tion of the frontiers of research where our knowledge is increasing steadily.