Author: Publisher:
ISBN:
Category : Biosphere
Languages : en
Pages : 36
Book Description
U.S. MAB Bulletin
Author: Drug-Induced Liver Injury
Author: Publisher: Academic Press
ISBN: 0128173173
Category : Medical
Languages : en
Pages : 290
Book Description
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
Monoclonal Antibody Production
Author: National Research CouncilPublisher: National Academies Press
ISBN: 0309173051
Category : Medical
Languages : en
Pages : 74
Book Description
The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.
Animal Welfare Information Center Newsletter
Author: Monoclonal Antibodies
Author: James W. GodingPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 344
Book Description
This book represents the distillation and critical evaluation of many hundreds of publications relating to the production and use of antibodies. Therefore it is restricted to the "core" techniques of production and handling of antibodies, and their use in studies of antigen analysis, purification and localization.
Science Education and Information Transfer
Author: C. A. TaylorPublisher: Elsevier
ISBN: 1483146480
Category : Science
Languages : en
Pages : 241
Book Description
Science Education and Information Transfer reviews developments in the areas of science education and information transfer. Topics covered include the use of games in science and technology education, transfer of information using readily available technology, and networking. The concepts of global learning and distance learning are also discussed, along with the use of video techniques and computer technology to transfer information. This volume is comprised of 10 chapters and begins with an overview of the information society, the usability of information, and the efficiency of information transfer. The discussion then turns to the use of games to teach science and technology; the most readily available technology for transferring information from teachers to students; and networking as a means to transfer information. The following chapters explore the concept and practice of global learning in the perspective of dissemination of scientific and technological knowledge in response to human needs; the use of microcomputers in the teaching of science; and some of the features of distance learning. The final chapter is devoted to teaching information technology in the classroom. This monograph will be of interest to planners, practitioners, researchers, and other professionals in the field of science education and information technology.
Administrations of Lunacy
Author: Mab SegrestPublisher: The New Press
ISBN: 1620972980
Category : Medical
Languages : en
Pages : 378
Book Description
"Whew! They going to send around here and tie you up and drag you off to Milledgeville. Them fat blue police chasing tomcats around alleys." —Berenice in The Member of the Wedding by Carson McCullers A scathing and original look at the racist origins of the field of modern psychiatry, told through the story of what was once the largest mental institution in the world, by the prize-winning author of Memoir of a Race Traitor After a decade of research, Mab Segrest, whose Memoir of a Race Traitor forever changed the way we think about race in America, turns sanity itself inside-out in a stunning book that will become an instant classic. In December 1841, the Georgia State Lunatic, Idiot, and Epileptic Asylum was founded on land taken from the Cherokee nation in the then-State capitol of Milledgeville. A hundred years later, it had become the largest insane asylum in the world with over ten thousand patients. To this day, it is the site of the largest graveyard of disabled and mentally ill people in the world. In April, 1949, Ebony magazine reported that for black patients, "the situation approaches Nazi concentration camp standards . . . unbelievable this side of Dante's Inferno." Georgia's state hospital was at the center of psychiatric practice and the forefront of psychiatric thought throughout the nineteenth and twentieth centuries in America—centuries during which the South invented, fought to defend, and then worked to replace the most developed slave culture since the Roman Empire. A landmark history of a single insane asylum at Milledgeville, Georgia, A Peculiar Inheritance reveals how modern-day American psychiatry was forged in the traumas of slavery, the Civil War, and Reconstruction, when African Americans carrying "no histories" entered from Freedmen's Bureau Hospitals and home counties wracked with Klan terror. This history set the stage for the eugenics and degeneracy theories of the twentieth century, which in turn became the basis for much of Nazi thinking in Europe. Segrest's masterwork will forever change the way we think about our own minds.
Antibody-Drug Conjugates
Author: Jeffrey WangPublisher: Springer
ISBN: 3319130811
Category : Medical
Languages : en
Pages : 248
Book Description
This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.
Information Geometry
Author: Geert VerdoolaegePublisher: MDPI
ISBN: 3038976326
Category : Juvenile Nonfiction
Languages : en
Pages : 355
Book Description
This Special Issue of the journal Entropy, titled “Information Geometry I”, contains a collection of 17 papers concerning the foundations and applications of information geometry. Based on a geometrical interpretation of probability, information geometry has become a rich mathematical field employing the methods of differential geometry. It has numerous applications to data science, physics, and neuroscience. Presenting original research, yet written in an accessible, tutorial style, this collection of papers will be useful for scientists who are new to the field, while providing an excellent reference for the more experienced researcher. Several papers are written by authorities in the field, and topics cover the foundations of information geometry, as well as applications to statistics, Bayesian inference, machine learning, complex systems, physics, and neuroscience.
HBase
Author: Lars GeorgePublisher: "O'Reilly Media, Inc."
ISBN: 1449396100
Category : Computers
Languages : en
Pages : 555
Book Description
"HBase: The Definitive Guide" provides the details for evaluating this high-performance, non-relational database, or putting it into practice right away. HBase's adoption rate is beginning to climb, and IT executives are asking pointed questions about this high-capacity database.