Molecular Biology of the Cell PDF Download

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Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0

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Author: Douglas W. DeSimone
Publisher: Springer Science & Business Media
ISBN: 3642359353
Category : Science
Languages : en
Pages : 260

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Book Description
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Author: Jeffrey H. Miner
Publisher: Elsevier
ISBN: 9780444518460
Category : Science
Languages : en
Pages : 268

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Book Description
Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix proteins that have been shown to be important for development, function, and disease. The book therefore both presents a broad view of the field and provides crucial details about some of the best-studied matrix molecules. * Written by leaders in the field * Discusses the potential of matrix components to be used as therapeutic tools for the treatment and prevention of cancer * Offers a section on integrin signaling and the development of the central nervous system, detailing the migration of neurons and the glia * Covers a diverse array of molecules such as laminins, collagens, heparan sulfate proteoglycans, integrins, and more

Author: Claude Gaultier
Publisher: Springer
ISBN: 1461475376
Category : Medical
Languages : en
Pages : 464

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Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.

Author: Roy Bicknell
Publisher: Cambridge University Press
ISBN: 9780521559904
Category : Science
Languages : en
Pages : 156

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The aim of the Handbooks in Practical Animal Cell Biology is to provide practical workbooks for those involved in primary cell culture. Each volume addresses a different cell lineage, and contains an introductory section followed by individual chapters on the culture of specific differentiated cell types. The authors of each chapter are leading researchers in their fields and use their first-hand experience to present reliable techniques in a clear and thorough manner. Endothelial Cell Culture contains chapters on endothelial cells derived from 1) lung, 2) bone marrow, 3) brain, 4) mammary glands, 5) skin, 6) adipose tissue, 7) female reproductive system, and 8) synovium.

Author: Francesco S. Pavone
Publisher: Taylor & Francis
ISBN: 1439849153
Category : Science
Languages : en
Pages : 465

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Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a

Author: Francesco Travascio
Publisher: BoD – Books on Demand
ISBN: 9535124153
Category : Science
Languages : en
Pages : 376

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Book Description
The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Author: William B. Coleman
Publisher: Academic Press
ISBN: 0128132582
Category : Medical
Languages : en
Pages : 636

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Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Author: Felicity N.E. Gavins
Publisher: Academic Press
ISBN: 0128013257
Category : Medical
Languages : en
Pages : 254

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Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease. - Covers a wide spectrum of organisms and provides analysis of pathogens and current therapeutic strategies in the context of their vasculature - Provides detailed perspectives on key components contributing to vascular pathogens from leaders in the field - Interfaces between both vascular biology and microbiology by encompassing information on how pathogens affect both macro and microvasculature - Includes coverage of the clinical aspects of sepsis and current therapeutic strategies and anti-sepsis drugs

Author: Tiago G. Fernandes
Publisher: Academic Press
ISBN: 0128166703
Category : Science
Languages : en
Pages : 286

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Engineering Strategies for Regenerative Medicine considers how engineering strategies can be applied to accelerate advances in regenerative medicine. The book provides relevant and up-to-date content on key topics, including the interdisciplinary integration of different aspects of stem cell biology and technology, diverse technologies, and their applications. By providing massive amounts of data on each individual, recent scientific advances are rapidly accelerating medicine. Cellular, molecular and genetic parameters from biological samples combined with clinical information can now provide valuable data to scientists, clinicians and ultimately patients, leading to the development of precision medicine. Equally noteworthy are the contributions of stem cell biology, bioengineering and tissue engineering that unravel the mechanisms of disease, regeneration and development. - Considers how engineering strategies can accelerate novel advances in regenerative medicine - Takes an interdisciplinary approach, integrating different aspects of research, technology and application - Provides up-to-date coverage on this rapidly developing area of medicine - Presents insights from an experienced and cross-disciplinary group of researchers and practitioners with close links to industry