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Author: H. Aldskogius Publisher: Springer Science & Business Media ISBN: 3642658679 Category : Medical Languages : en Pages : 78
Book Description
In the previous study (Part I) a description was given of the ultrastructural changes occurring during indirect Wallerian degeneration in the intramedullary root fibre region of the kitten hypoglossal nerve. One of the striking features of this degeneration process was the appearance at an early stage of micro glial cells completely covered by myelin, which apparently participated in phago cytosis of degenerating axoplasm and to a small extent of their own myelin covering. Evidence was obtained indicating that the numerous degenerating glial cells seen somewhat later in the degeneration process were derived from these myelin-covered microglial cells. Since glial cells of the type described in the previous study have never been implicated in the process of direct Wallerian degeneration, the possibility exists that they may in fact be characteristic for indirect Wallerian degeneration. However, this possibility cannot be adequately assessed unless our present rather scanty knowledge concerning the early glial reaction during direct Wallerian degeneration is extended. Therefore the present study has been undertaken to examine the ultrastructural changes during direct W allerian degeneration in the kitten, with particular reference to the possible occurrence of myelin-covered microglial cells and degenerating glial cells of the type described in the previous study (see Part I). Since no systematic ultra structural study on direct Wallerian degeneration in immature animals seem to exist, observations on changes in the myelinated nerve fibres and the different types of glial cells have been included.
Author: H. Aldskogius Publisher: Springer Science & Business Media ISBN: 3642658679 Category : Medical Languages : en Pages : 78
Book Description
In the previous study (Part I) a description was given of the ultrastructural changes occurring during indirect Wallerian degeneration in the intramedullary root fibre region of the kitten hypoglossal nerve. One of the striking features of this degeneration process was the appearance at an early stage of micro glial cells completely covered by myelin, which apparently participated in phago cytosis of degenerating axoplasm and to a small extent of their own myelin covering. Evidence was obtained indicating that the numerous degenerating glial cells seen somewhat later in the degeneration process were derived from these myelin-covered microglial cells. Since glial cells of the type described in the previous study have never been implicated in the process of direct Wallerian degeneration, the possibility exists that they may in fact be characteristic for indirect Wallerian degeneration. However, this possibility cannot be adequately assessed unless our present rather scanty knowledge concerning the early glial reaction during direct Wallerian degeneration is extended. Therefore the present study has been undertaken to examine the ultrastructural changes during direct W allerian degeneration in the kitten, with particular reference to the possible occurrence of myelin-covered microglial cells and degenerating glial cells of the type described in the previous study (see Part I). Since no systematic ultra structural study on direct Wallerian degeneration in immature animals seem to exist, observations on changes in the myelinated nerve fibres and the different types of glial cells have been included.
Author: T. Herdegen Publisher: Springer Science & Business Media ISBN: 1402025416 Category : Medical Languages : en Pages : 707
Book Description
This book builds a novel bridge from molecular research to clinical therapy. This approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration.
Author: Kjell Fuxe Publisher: Elsevier ISBN: 1483146472 Category : Nature Languages : en Pages : 617
Book Description
Dynamics of Degeneration and Growth in Neurons is a collection of papers presented at the International Symposium on the Dynamics of Degeneration and Growth in Neurons, held in Stockholm, Sweden, on May 16-18, 1973. Contributors explore the dynamics of degeneration and growth of central and peripheral neurons, touching on a wide range of topics such as the neurotoxic action of 6-hydroxy-dopa on central catecholamine neurons; axonal transport of proteins in growing and regenerating neurons; and collateral reinnervation in the central nervous system. Comprised of 50 chapters, this volume begins with an overview of degeneration processes in central and peripheral neurons. Results of microfluorimetric and neurochemical studies on degenerating and regenerating adrenergic nerves are presented. The next section is devoted to axoplasmic transport as a mechanism for axonal support and growth and includes chapters dealing with the effects of degeneration and axoplasmic transport blockade on synaptic ultrastructure, function, and protein composition; the role of axoplasmic flow in trophism of skeletal muscle; and proximodistal transport of acetylcholine in peripheral cholinergic neurons. The remaining chapters discuss the nerve growth factor receptor and its specific binding in sympathetic ganglia; the noradrenergic innervation of cerebellar Purkinje cells; and the possible role of brain and peripheral monoamines in the ontogenesis of normal and drug-induced responses in the immature mammal. This book will be of interest to physiologists and neurologists.
Author: H. Aldskogius
Author: H. Aldskogius
Author: Håkan Aldskogius
Author: H. Aldskogius
Author: 
Author: T. Herdegen
Author: 
Author: Library of Congress. Copyright Office
Author: Kjell Fuxe
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Author: Georg W. Kreutzberg