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Author: Asja Muhiu0107 Publisher: ISBN: Category : Languages : en Pages :
Book Description
In-vivo animal model histological analysis of TiMg composite material for dental implantsu0106atiu0107 Amir, Muhiu0107 Asja, Beu0161iroviu0107 Hajrudin, Balog Martin, Krizik Peter, Schauperl ZdravkoBackground: One of the main issues concerning dental implant materials arises from their Youngu2019s modulus being considerably higher than that of bone, which can generate stress-shielding effect and periimplant bone atrophy during loading. By use of advanced powder metallurgy novel titanium-magnesium (Ti12Mg) composite has been designed and consolidated. Results of ISO-standard based tests for dental implants demonstrated superior mechanical properties, in-vitro tests showed adequate biocorrosion.Aim: The aim of the study was to produce common dimension implants and assess the in-vivo osseointegration potentials of Ti12Mg composite metal on animal model. Materials and methods: Study design was presented to ethical committees of both UNIZG School of Dental Medicine and UNISA Faculty of Veterinary Medicine, and the approvals acquired. Consolidated Ti12Mg implant material was roll-pressed into a 3,5mm diameter bar and machined into 12 implants of 11mm length. Implant neck geometry was modeled to allow for screw-motion placement. Four sheep of various ages were chosen from natural pasture farm with HACCP certificate and kept 30 days in controlled conditions with identical pasture prior to surgery. At the day of surgery three implants were epicrestally placed using regular implant surgical protocol in right tibia of each sheep 2cm apart. After 4, 8 and 12 weeks from each sheep one implant and the surrounding bone were removed by a 7mm diameter trephine bur, the samples prepared and histologically analyzed. All surgeries were performed in general anesthesia. After completion of the investigation sheep were healthy and in normal function. Results: Histological analyzes demonstrated formation of bone at the bone to implant contact. Time-related bone maturation was typical for dental implants. However, BIC at 12 weeks was more mature at Ti12Mg implants in comparison to the commercially available implant. Histomorphometric analysis showed average BIC values within the bone marrow at 4 weeks 52%, at 8 weeks 81% and at 12 weeks 96%. BIC values within the cortical bone were 59% at 4 weeks, 89% at 8 weeks and 98% at 12 weeks. No signs of gaseous enclosures were determined in the surrounding bone. Conclusions and clinical implications: Proposed Ti12Mg composite, with Mg phase acting as beneficiary modulator for generating an osseoconductive surface via spontaneous dilution in body environment as well as bone formation stimulant, suggests this material answers crucial demands for dental implants. Information concerning similar studies is scarce, and implant material where porous bioactive bimetallic composite is obtained with similar properties, has not so far been proposed.
Author: Asja Muhiu0107 Publisher: ISBN: Category : Languages : en Pages :
Book Description
In-vivo animal model histological analysis of TiMg composite material for dental implantsu0106atiu0107 Amir, Muhiu0107 Asja, Beu0161iroviu0107 Hajrudin, Balog Martin, Krizik Peter, Schauperl ZdravkoBackground: One of the main issues concerning dental implant materials arises from their Youngu2019s modulus being considerably higher than that of bone, which can generate stress-shielding effect and periimplant bone atrophy during loading. By use of advanced powder metallurgy novel titanium-magnesium (Ti12Mg) composite has been designed and consolidated. Results of ISO-standard based tests for dental implants demonstrated superior mechanical properties, in-vitro tests showed adequate biocorrosion.Aim: The aim of the study was to produce common dimension implants and assess the in-vivo osseointegration potentials of Ti12Mg composite metal on animal model. Materials and methods: Study design was presented to ethical committees of both UNIZG School of Dental Medicine and UNISA Faculty of Veterinary Medicine, and the approvals acquired. Consolidated Ti12Mg implant material was roll-pressed into a 3,5mm diameter bar and machined into 12 implants of 11mm length. Implant neck geometry was modeled to allow for screw-motion placement. Four sheep of various ages were chosen from natural pasture farm with HACCP certificate and kept 30 days in controlled conditions with identical pasture prior to surgery. At the day of surgery three implants were epicrestally placed using regular implant surgical protocol in right tibia of each sheep 2cm apart. After 4, 8 and 12 weeks from each sheep one implant and the surrounding bone were removed by a 7mm diameter trephine bur, the samples prepared and histologically analyzed. All surgeries were performed in general anesthesia. After completion of the investigation sheep were healthy and in normal function. Results: Histological analyzes demonstrated formation of bone at the bone to implant contact. Time-related bone maturation was typical for dental implants. However, BIC at 12 weeks was more mature at Ti12Mg implants in comparison to the commercially available implant. Histomorphometric analysis showed average BIC values within the bone marrow at 4 weeks 52%, at 8 weeks 81% and at 12 weeks 96%. BIC values within the cortical bone were 59% at 4 weeks, 89% at 8 weeks and 98% at 12 weeks. No signs of gaseous enclosures were determined in the surrounding bone. Conclusions and clinical implications: Proposed Ti12Mg composite, with Mg phase acting as beneficiary modulator for generating an osseoconductive surface via spontaneous dilution in body environment as well as bone formation stimulant, suggests this material answers crucial demands for dental implants. Information concerning similar studies is scarce, and implant material where porous bioactive bimetallic composite is obtained with similar properties, has not so far been proposed.
Author: Sergey V. Dorozhkin Publisher: CRC Press ISBN: 9814364177 Category : Science Languages : en Pages : 863
Book Description
Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
Author: Mona Marei Publisher: Springer Nature ISBN: 3031025814 Category : Science Languages : en Pages : 164
Book Description
Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry
Author: Gottfried Schmalz Publisher: Springer Science & Business Media ISBN: 3540777822 Category : Medical Languages : en Pages : 392
Book Description
This book provides a comprehensive and scientifically based overview of the biocompatibility of dental materials. Up-to-date concepts of biocompatibility assessment are presented, as well as information on almost all material groups used in daily dentistry practice. Furthermore, special topics of clinical relevance (e.g,, environmental and occupational hazards and the diagnosis of adverse effects) are covered. The book will: improve the reader’s ability to critically analyze information provided by manufacturers supply a better understanding of the biocompatibility of single material groups, which will help the reader choose the most appropriate materials for any given patient and thus prevent adverse effects from developing provide insights on how to conduct objective, matter-of-fact discussions with patients about the materials to be used in dental procedures advise readers, through the use of well-documented concepts, on how to treat patients who claim adverse effects from dental materials feature clinical photographs that will serve as a reference when analyzing clinical symptoms, such as oral mucosa reactions.
Author: Ulrich Meyer Publisher: Springer Science & Business Media ISBN: 3540777555 Category : Medical Languages : en Pages : 1049
Book Description
"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.
Author: Per-Ingvar Brånemark Publisher: Quintessence Publishing (IL) ISBN: Category : Medical Languages : en Pages : 360
Book Description
" This book provides the prosthodontist and oral surgeon for the first time with a safe, predictable, and scientifically proven method for permanently anchoring artificial tooth abutments in the jawbones. It combines the osseointegration research results of biologists, physicists, bioengineers, oral surgeons, and prosthodontists to demonstrate step-by-step how to achieve long-term osseointegration of dental implants" -- Amazon.
Author: Noam Eliaz Publisher: Springer Science & Business Media ISBN: 1461439426 Category : Technology & Engineering Languages : en Pages : 521
Book Description
This book reviews the current understanding of the mechanical, chemical and biological processes that are responsible for the degradation of a variety of implant materials. All 18 chapters will be written by internationally renowned experts to address both fundamental and practical aspects of research into the field. Different failure mechanisms such as corrosion, fatigue, and wear will be reviewed, together with experimental techniques for monitoring them, either in vitro or in vivo. Procedures for implant retrieval and analysis will be presented. A variety of biomaterials (stainless steels, titanium and its alloys, nitinol, magnesium alloys, polyethylene, biodegradable polymers, silicone gel, hydrogels, calcium phosphates) and medical devices (orthopedic and dental implants, stents, heart valves, breast implants) will be analyzed in detail. The book will serve as a broad reference source for graduate students and researchers studying biomedicine, corrosion, surface science, and electrochemistry.
Author: Ilser Turkyilmaz Publisher: BoD – Books on Demand ISBN: 9535117416 Category : Medical Languages : en Pages : 278
Book Description
Implant dentistry has changed and enhanced significantly since the introduction of osseointegration concept with dental implants. Because the benefits of therapy became apparent, implant treatment earned a widespread acceptance. Therefore, the need for dental implants has caused a rapid expansion of the market worldwide. Dental implantology continues to excel with the developments of new surgical and prosthodontic techniques, and armamentarium. The purpose of this book named Current Concepts in Dental Implantology is to present a novel resource for dentists who want to replace missing teeth with dental implants. It is a carefully organized book, which blends basic science, clinical experience, and current and future concepts. This book includes ten chapters and our aim is to provide a valuable source for dental students, post-graduate residents and clinicians who want to know more about dental implants.
Author: Asja Muhiu0107
Author: Asja Muhiu0107
Author: 
Author: Hugh U. Cameron
Author: Sergey V. Dorozhkin
Author: Mona Marei
Author: Gottfried Schmalz
Author: Ulrich Meyer
Author: Per-Ingvar Brånemark
Author: Noam Eliaz
Author: Ilser Turkyilmaz