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Author: Donna Darlington Publisher: ISBN: Category : Languages : en Pages :
Book Description
Treated mice were studied using standard behavioral tests to determine the effects of infusion on the multiple cognitive domains affected by AD, followed by biochemical and histological analyses that included A&beta load and amyloid precursor protein (APP) processing. Specifically, PSAPP mice and their wild-type (WT) littermates were treated monthly with a peripheral HUCBC infusion over a period of 6 and 10 months, followed by cognitive and motor evaluation. Additionally, based on reports that tumor cells can originate from stem cells present in HUCB, we further examined whether monocytes purified from HUCBCs would have a similar significant effect on the reduction of AD-like pathology in PSAPP mice. HUCB cells homed into tissues including the brain. The principal finding was significant reduction in A&beta levels and &beta&ndashamyloid plaques following low-dose infusions of both HUCBC&ndash derived mononuclear cells as well as HUCBC-derived monocytes, with the monocytes providing a stronger effect. Results further demonstrated that HUCBC and HUCBC&ndash derived monocyte infusion could improve memory function and locomotor ability in treated PSAPP mice. A possible reason for behavioral improvements in these animals may be the significant reduction in both A&beta levels and plaque load. This study also identified significant reduction in microglial activation and astrocytosis, both of which can contribute to AD pathology. In conclusion, our data suggest that it might be the HUCBC&ndashderived monocytic population rather than stem cells that are responsible for the reduction in AD pathology.
Author: Donna Darlington Publisher: ISBN: Category : Languages : en Pages :
Book Description
Treated mice were studied using standard behavioral tests to determine the effects of infusion on the multiple cognitive domains affected by AD, followed by biochemical and histological analyses that included A&beta load and amyloid precursor protein (APP) processing. Specifically, PSAPP mice and their wild-type (WT) littermates were treated monthly with a peripheral HUCBC infusion over a period of 6 and 10 months, followed by cognitive and motor evaluation. Additionally, based on reports that tumor cells can originate from stem cells present in HUCB, we further examined whether monocytes purified from HUCBCs would have a similar significant effect on the reduction of AD-like pathology in PSAPP mice. HUCB cells homed into tissues including the brain. The principal finding was significant reduction in A&beta levels and &beta&ndashamyloid plaques following low-dose infusions of both HUCBC&ndash derived mononuclear cells as well as HUCBC-derived monocytes, with the monocytes providing a stronger effect. Results further demonstrated that HUCBC and HUCBC&ndash derived monocyte infusion could improve memory function and locomotor ability in treated PSAPP mice. A possible reason for behavioral improvements in these animals may be the significant reduction in both A&beta levels and plaque load. This study also identified significant reduction in microglial activation and astrocytosis, both of which can contribute to AD pathology. In conclusion, our data suggest that it might be the HUCBC&ndashderived monocytic population rather than stem cells that are responsible for the reduction in AD pathology.
Author: Dr. Biplabendu Talukdar Publisher: Archers & Elevators Publishing House ISBN: 8119653971 Category : Antiques & Collectibles Languages : en Pages : 215
Book Description
At the very beginning, I wish to express my sincere gratitude to my respected principal investigator Prof Dr. Niranjan Bhattacharya, former professor and HOD, Department of Regenerative Medicine and Translational Science, STM, Kolkata and co-investigator Prof. Dr Rita Ghosh, professor department of Biochemistry and Biophysics, university of Kalyani. I have received his and her valuable guidance at every moment in my long journey. Without the continuous support it would have been very difficult to complete the work. I also express my sincere thanks to the respected Professor Dr. Sanjukta Bhattacharya, Professor (retired), Jadavpur University, for her continuous support during my research work and assistance in developing tools of research.
Author: Karen Devine Publisher: Taylor & Francis ISBN: 1317555457 Category : Law Languages : en Pages : 224
Book Description
Since the therapeutic value of umbilical cord blood (UCB) stem cells was first recognised in the late 1980s, there has been a proliferation of both public and private UCB banks worldwide. However, the ability to utilise such a potentially valuable resource has provoked a number of controversies. In a distinctly accessible style, this book unpacks the socio-legal implications of the UCB collection process and constructs a detailed analysis of the law and ethics that surrounds UCB banking in the UK, including ownership of the cells. Its enquiry is located within the theoretical framework of altruism versus self-interest and explores the notions of risk and choice associated with this distinctive blend of public/private healthcare provision. The book evaluates the impact of the Human Tissue Act 2004 and the European Union Tissues and Cells Directive (2004/23/EC) on the UCB industry and provides a unique insight into the effect that the law may have on the NHS whose maternity staff and premises are used to collect UCB. This book would be of interest primarily to a UK readership in addition to expectant families, health professionals, students, academics, practitioners and the UCB industry elsewhere in the world.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309095867 Category : Medical Languages : en Pages : 335
Book Description
With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program examines: The role of cord blood in stem cell transplantation The current status of blood banks already in existence The optimal structure for the cord blood program The current use and utility of cord blood for stem cell transplants The best way to advance the use of cord blood units and make them available for research Expert advice from leaders in the fields of economics, public health, medicine, and biostatistics combine to make this very timely and topical book useful to a number of stakeholders.
Author: Anthony Atala Publisher: Academic Press ISBN: 0128120630 Category : Medical Languages : en Pages : 438
Book Description
Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells
Author: Niranjan Bhattacharya Publisher: Springer Science & Business Media ISBN: 1848827180 Category : Medical Languages : en Pages : 455
Book Description
The proposed book is a holistic review of the clinical use of placental substances, amniotic fluid, the umbilical cord and its contents. It is intended to be a unique presentation of the current advances as well as also discussing the future applications of these substances. Attention is yet to be focused on the widespread clinical use of pregnancy-related biological substances. The aim for this book is to inform clinicians of the use of such materials and increase awareness of their therapeutic benefits. As such, this reference resource will be of great value to hematologists, rheumatologists, cardiologists, transplant technologists and all involved in regenerative medicine.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309170427 Category : Science Languages : en Pages : 112
Book Description
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Author: Adam F. Poniatowski Publisher: ISBN: Category : Languages : en Pages :
Book Description
HUCB stem cells cultured in simulated microgravity exhibited significant nucleated cell and CD34+ cell death, reduced CFU production, and prolonged quiescence over a three-day culture period. Establishment of a post-microgravity long-term static culture (LTSC) led to complete hematopoietic exhaustion within fourteen days. Thus culture in simulated microgravity under the conditions tested proved to be too damaging to HUCB stem cells to allow improved long-term hematopoietic expansion. It is possible that technical problems, including incorrect vessel rotation speed, may have led to cell death in the HARV, while cell-related issues, including low initial cell concentrations and high initial cell primitivity, may have hindered cell growth.
Author: Donna Darlington
Author: Donna Darlington
Author: Dr. Biplabendu Talukdar
Author: Karen Devine
Author: Institute of Medicine
Author: Anthony Atala
Author: Catherine Elizabeth Carow
Author: Niranjan Bhattacharya
Author: Institute of Medicine
Author: Adam F. Poniatowski
Author: Albert M. Kligman