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Author: Md. Naimat Ali Publisher: Elsevier ISBN: 0443185115 Category : Medical Languages : en Pages : 308
Book Description
Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides broad coverage to diverse aspects of immunotoxicogenomics. The book covers the major mechanisms and effects of toxic substances on the immune system and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, emerging and future trends in immunotoxicogenomics.The book starts off with a discussion of the systemic approach to the study of toxicants. It also looks at the current genomic tools used to assess immunotoxicity and the systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, the use of gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data. Future trends round off the discussion in the book. Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides a collaborative multidisciplinary approach for researchers in the fields of toxicology, genetics, and immunology and others engaged in the study on the effects of toxic substances on immune responses. - Offers background and progress information for clinical applications and potential immunotoxicogenomics prospects - Covers the major mechanisms currently known by which toxic substances affect the immune system and gene expression - Provides a multidisciplinary approach to immunotoxicology, with updated content on fundamentals, the latest breakthroughs, clinical applications, and future perspectives
Author: Md. Naimat Ali Publisher: Elsevier ISBN: 0443185115 Category : Medical Languages : en Pages : 308
Book Description
Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides broad coverage to diverse aspects of immunotoxicogenomics. The book covers the major mechanisms and effects of toxic substances on the immune system and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, emerging and future trends in immunotoxicogenomics.The book starts off with a discussion of the systemic approach to the study of toxicants. It also looks at the current genomic tools used to assess immunotoxicity and the systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, the use of gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data. Future trends round off the discussion in the book. Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides a collaborative multidisciplinary approach for researchers in the fields of toxicology, genetics, and immunology and others engaged in the study on the effects of toxic substances on immune responses. - Offers background and progress information for clinical applications and potential immunotoxicogenomics prospects - Covers the major mechanisms currently known by which toxic substances affect the immune system and gene expression - Provides a multidisciplinary approach to immunotoxicology, with updated content on fundamentals, the latest breakthroughs, clinical applications, and future perspectives
Author: Saura C. Sahu Publisher: John Wiley & Sons ISBN: 0470699647 Category : Science Languages : en Pages : 422
Book Description
Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include: mechanistic toxicogenomics analysis and interpretation of toxicogenomic data principles of data mining in toxicogenomics design issues in toxicogenomics studies sources of variability in toxicogenomic assays Escherichia coli stress response as a tool for detection of toxicity toxicogenomics as a tool to assess immunotoxicity toxicogenomics and ecogenomics for studying endocrine disruption and basic biology use of toxicogenomics as an early predictive tool for hepatotoxicity nutrigenomics: the application of genomic signatures in nutrition-related research application of toxicogenomics in drug discovery potential uses of toxicogenomic biomarkers in occupational health and risk assessment usefulness of toxicogenomics in the regulatory environment perspectives on toxicogenomics at the US Environmental Protection Agency Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products.
Author: National Research Council Publisher: National Academies Press ISBN: 0309112982 Category : Science Languages : en Pages : 300
Book Description
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Author: Cornelis A. M. van Gestel Publisher: CRC Press ISBN: 1439830096 Category : Medical Languages : en Pages : 312
Book Description
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Author: Jos Kleinjans Publisher: Academic Press ISBN: 0123978718 Category : Medical Languages : en Pages : 367
Book Description
Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores 'omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing. - Describes the state-of-the-art in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and reproduction toxicity - Illustrates how to validate toxicogenomics-based alternative test models and provides an outlook to societal and economic implementation of these novel assays - Includes an overview of current testing methods and risk assessment frameworks - Provides a real-world assessment by articulating the current development and challenges in toxicogenomics while suggesting ways to move this field forward
Author: Jürgen Borlak Publisher: John Wiley & Sons ISBN: 3527604510 Category : Science Languages : en Pages : 705
Book Description
Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies. The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives. Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."
Author: Emanuela Corsini Publisher: John Wiley & Sons ISBN: 3527676996 Category : Science Languages : en Pages : 355
Book Description
The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Author: Hugh MacPherson Publisher: Elsevier Health Sciences ISBN: 0443100292 Category : Medical Languages : en Pages : 288
Book Description
This is the first book to set out a full range of research strategies for evaluating the clinical practice of acupuncture. Leading acupuncturists and researchers with international reputations share their expertise. They illustrate their descriptions with practical examples of what has worked and what has not. It outlines many of the key challenges in the field. These challenges relate to the nature of acupuncture and the gap between current research evidence and the actual experiences of acupuncturists in the field. By focusing the chapters on key research questions, rather than methods, the book has a user-friendly feel. Each chapter is easily accessible with brief explanations of research designs as well as vignettes of relevant past research. The book is based on a deep understanding of acupuncture, with its inherent complexity in practice, whether based on traditional principles or more modern concepts. By incorporating a more sophisticated understanding of the field, this book details a range of strategies aiming to develop the evidence base with the utmost rigour. It is the first book on acupuncture research to take this unique view, integrating the very best of evidence-based medicine with a genuine sensitivity to the discipline of acupuncture, from its traditional and holistic roots to its more modern interpretations.
Author: Hisham K. Hamadeh Publisher: John Wiley & Sons ISBN: 9780471434177 Category : Science Languages : en Pages : 386
Book Description
Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies. A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support the textual explanations. It offers practical guidance to investigators wishing to pursue this line of research, and lists key relevant software and Internet resources.
Author: Darrell R. Boverhof Publisher: John Wiley & Sons ISBN: 1118008987 Category : Science Languages : en Pages : 470
Book Description
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
Author: Md. Naimat Ali
Author: Md. Naimat Ali
Author: Saura C. Sahu
Author: National Research Council
Author: Cornelis A. M. van Gestel
Author: Jos Kleinjans
Author: Jürgen Borlak
Author: Emanuela Corsini
Author: Hugh MacPherson
Author: Hisham K. Hamadeh
Author: Darrell R. Boverhof