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Author: Kenneth Murphy Publisher: Garland Science ISBN: 9780815344575 Category : Medical Languages : en Pages :
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Kenneth Murphy Publisher: Garland Science ISBN: 9780815344575 Category : Medical Languages : en Pages :
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Stefano Goffredo Publisher: Springer ISBN: 3319313053 Category : Science Languages : en Pages : 842
Book Description
This volume presents a broad panorama of the current status of research of invertebrate animals considered belonging to the phylum Cnidaria, such as hydra, jellyfish, sea anemone, and coral. In this book the Cnidarians are traced from the Earth’s primordial oceans, to their response to the warming and acidifying oceans. Due to the role of corals in the carbon and calcium cycles, various aspects of cnidarian calcification are discussed. The relation of the Cnidaria with Mankind is approached, in accordance with the Editors’ philosophy of bridging the artificial schism between science, arts and Humanities. Cnidarians' encounters with humans result in a broad spectrum of medical emergencies that are reviewed. The final section of the volume is devoted to the role of Hydra and Medusa in mythology and art.
Author: Publisher: Academic Press ISBN: 0128244860 Category : Science Languages : en Pages : 358
Book Description
Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers. - Overview of the history and development of efforts to pharmacologically inhibit RAS. - Discussion of the biochemistry and biology of different RAS mutant proteins and how this might be effectively leveraged in the development of anti-RAS therapies. - Up-to-date reviews of the cutting-edge approaches to develop new anti-RAS pharmacologics.
Author: Andrea Bottaro Publisher: Frontiers Media SA ISBN: 2889669483 Category : Medical Languages : en Pages : 138
Book Description
The explosion of basic and applied immunology in the first decades of the 21st century has brought forth new opportunities and challenges for immunology education at all academic levels, from professional to undergraduate, medical, graduate and post-graduate instruction. Moreover, developing methods and techniques for educating general audiences on the importance and benefits of immunology will be critical for increasing public awareness and support. One major immediate challenge consists in accommodating, within the confines of traditional immunology curricula, a body of knowledge that continues to grow exponentially in both size and complexity. Furthermore, the practical toolbox of immunological research has vastly expanded, and even in the present environment of highly interdisciplinary and collaborative science, future immunologists will likely need to be at least conversant in, for instance, computational, structural and system biology, nanotechnology and tissue engineering. At the same time, our perspective of the immune system has progressively developed from primarily a host defense mechanism to a fundamental homeostatic system with organism-wide physiological and clinical significance, and with potentially transformative biotechnological and therapeutic applications. As a consequence, in addition to stand-alone courses, immunology is increasingly integrated into other courses, or distributed longitudinally, throughout a multi-year curriculum. This necessitates inter-disciplinary approaches to reach an expanding range of disciplines, as diverse as neurobiology, cancer biology/ oncology, infectious diseases, pharmacology, orthopedics and bioengineering. Creative approaches and pedagogical flexibility will be needed to avoid the pitfall of “one-size-fits-all” instruction, and to tailor level- and discipline-appropriate content to different types of students using multiple teaching formats. Finally, like most other disciplines, immunology education is also under strong pressure to introduce new didactic strategies that are relevant and meaningful to a generation of students who are “digital natives”, comfortable with and expect on-demand and multi-modal learning, diversified sources, and active engagement. Thankfully, the dynamic and interactive behavior of immune system cells, now visualized with striking immediacy by in vivo imaging, has the ability to capture and hold the interest of even the most jaded learner. The need for an increasingly immunology-knowledgeable workforce – not just academic and industry scientists, but also clinical and research lab technicians, biomedical engineers, and physicians in a growing array of specialties - will also expand job opportunities for immunologists as educators, and for content creators dedicated to generating new didactic tools in this field. Acknowledgement: We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS).
Author: Michelle B.F. Wong Publisher: Europa Edizioni ISBN: Category : Medical Languages : en Pages : 293
Book Description
This dense study conducted by Prof. Dr. Mike K.S. Chan and Prof. Dr. Michelle B.F. Wong, with the support of a professional team of researchers, highlights how important is to delve deeper into the study of the thymus gland which plays a crucial role in immune system health. As we read in the forewords the topics presented are the results of a collaboration between experts coming from various fields such as immunology, gerontology, regenerative medicine, and clinical practice. This comprehensive book can strengthen the communication and collaboration among these disciplines, fostering a more holistic approach to addressing age-related health challenges. Bioregenerative medicine in general, and Thymic regeneration therapies are an important part of the daily medical practice. THYMUS THERAPY represents a pivotal study and another scientific milestone that puts once again Prof. Chan and his Team at the forefront worldwide. Prof. Dato Sri Dr. Mike K.S. Chan, is a pioneer of Cellular, Organo and Cell Membrane Therapies in Europe and Asia since the early 1980’s. He founded one of the world’s largest research groups of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, bio-regenerative medicine, and stemcell therapies. Author & co-author of numerous books and articles in the fields of cell therapy, immunology, bio-regenerative sciences, nutrition, and innovator of cellular based nutraceuticals & cosmeceuticals, Prof. Mike Chan is also the founder of European Wellness Biomedical Group—an International chain of research and treatment facilities (European Wellness Centers & Retreats) involved in anti-aging, longevity and education (European Wellness Academy). He chairs and also sits on board on numerous prominent antiaging and cell therapy associations of the world. Prof. Dato Sri Dr. Michelle Wong Bi Fah, ND, PhD is a scientist, researcher and educator actively involved in research and development (R&D) work on stem cells focusing on Fetal Precursor Stem-Cell Therapy. She is the Co-Founder/Senior Technical Advisor and Researcher in FCTI Inc., specialising in Stem cell Research and Bio-Regenerative Medicine for more than three decades. A prominent speaker, Michelle Wong presents at educational programs and global conferences on stem cells, cell therapy and biological medicine for physicians and healthcare practitioners worldwide.
Author: Stephen T. Abedon Publisher: Frontiers Media SA ISBN: 2889452514 Category : Languages : en Pages : 394
Book Description
Historically, the first observation of a transmissible lytic agent that is specifically active against a bacterium (Bacillus anthracis) was by a Russian microbiologist Nikolay Gamaleya in 1898. At that time, however, it was too early to make a connection to another discovery made by Dmitri Ivanovsky in 1892 and Martinus Beijerinck in 1898 on a non-bacterial pathogen infecting tobacco plants. Thus the viral world was discovered in two of the three domains of life, and our current understanding is that viruses represent the most abundant biological entities on the planet. The potential of bacteriophages for infection treatment have been recognized after the discoveries by Frederick Twort and Felix d’Hérelle in 1915 and 1917. Subsequent phage therapy developments, however, have been overshadowed by the remarkable success of antibiotics in infection control and treatment, and phage therapy research and development persisted mostly in the former Soviet Union countries, Russia and Georgia, as well as in France and Poland. The dramatic rise of antibiotic resistance and especially of multi-drug resistance among human and animal bacterial pathogens, however, challenged the position of antibiotics as a single most important pillar for infection control and treatment. Thus there is a renewed interest in phage therapy as a possible additive/alternative therapy, especially for the infections that resist routine antibiotic treatment. The basis for the revival of phage therapy is affected by a number of issues that need to be resolved before it can enter the arena, which is traditionally reserved for antibiotics. Probably the most important is the regulatory issue: How should phage therapy be regulated? Similarly to drugs? Then the co-evolving nature of phage-bacterial host relationship will be a major hurdle for the production of consistent phage formulae. Or should we resort to the phage products such as lysins and the corresponding engineered versions in order to have accurate and consistent delivery doses? We still have very limited knowledge about the pharmacodynamics of phage therapy. More data, obtained in animal models, are necessary to evaluate the phage therapy efficiency compared, for example, to antibiotics. Another aspect is the safety of phage therapy. How do phages interact with the immune system and to what costs, or benefits? What are the risks, in the course of phage therapy, of transduction of undesirable properties such as virulence or antibiotic resistance genes? How frequent is the development of bacterial host resistance during phage therapy? Understanding these and many other aspects of phage therapy, basic and applied, is the main subject of this Topic.
Author: Anne Dickinson Publisher: Frontiers Media SA ISBN: 2889456064 Category : Science Languages : en Pages : 143
Book Description
Haematopoietic stem cell transplantation was initiated in the early 1970’s by pioneers studying radiation-induced bone marrow damage and blood transfusion. Since that time there have been over one million transplants and over 34 million donors registered with the world marrow donor association. This special edition of Frontiers in Immunology highlights the research achievements which led to the curative therapy of haematopoietic stem cell transplantation (HSCT) but also reviews the ongoing complications such as graft versus host disease (GvHD) and infection caused by the procedure. Early animal and human studies are reviewed as well as those which led to the development of changes in transplant protocols such as peripheral blood stem cell and cord blood transplants and the harnessing of graft versus leukaemia (GvL) effects by donor lymphocyte infusions. The eBook covers immunogenetics, the role of biomarkers, and future developments of the therapy which will aim to further improve the outcome for HSCT patients. The eBook is divided into 8 chapters dealing with animal studies; a history of early human studies; the pathophysiology of HSCT; graft versus host disease; graft versus leukaemia effects; immune reconstitution; non-HLA immunogenetics and future developments, including use of mesenchymal stem cells, virus specific T cells and chimeric antigen receptor (CAR) therapy.
Author: Arthur M. Silverstein Publisher: Elsevier ISBN: 0080925839 Category : Medical Languages : en Pages : 445
Book Description
This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline. - A professional-level intellectual history of the development of immunology from about 1720 to 1970, with emphasis placed on the social climate of the scientific milieu in which modern immunology evolved - Written by an author very well known both as a historian of medical science and for his substantial research contributions to the immunopathology of the eye - The only complete history of immunology available
Author: Edward J. Moticka Publisher: Newnes ISBN: 0123983754 Category : Medical Languages : en Pages : 396
Book Description
A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. - Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles - Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology - Presents concepts such as the division of lymphocytes into functionally different populations in their historical context - Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells
Author: Kenneth Murphy
Author: Kenneth Murphy
Author: Stefano Goffredo
Author: 
Author: Andrea Bottaro
Author: Michelle B.F. Wong
Author: Stephen T. Abedon
Author: Anne Dickinson
Author: Arthur M. Silverstein
Author: Edward J. Moticka
Author: Steven A. Frank