Immunologic and Pharmacologic Interventions to Prevent Hyperacute Rejection in Pulmonary Xenotransplantation PDF Download

Author: David Marshall Kulick
Publisher:
ISBN:
Category : Graft rejection
Languages : en
Pages : 380

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Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 794

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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 874

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Author: Clinton B. Mathias
Publisher: Springer Nature
ISBN: 3030199223
Category : Medical
Languages : en
Pages : 410

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Book Description
Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are detailed. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.​

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1860

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Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309175267
Category : Medical
Languages : en
Pages : 134

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Book Description
Xenotransplantation involves the transplantation of cells, tissues, and whole organs from one species to another. Interest in animal-to-human xenotransplants has been spurred by the continuing shortage of donated human organs and by advances in knowledge concerning the biology of organ and tissue rejection. The scientific advances and promise, however, raise complex questions that must be addressed. This book considers the scientific and medical feasibility of xenotransplantation and explores the ethical and public policy issues surrounding the possibility of renewed clinical trials. The volume focuses on the science base of xenotransplantation, public health risks of infectious disease transmission, and ethical and public policy issues, including the views of patients and their families.

Author: Andrew P. Zbar
Publisher: Springer Science & Business Media
ISBN: 9781852334826
Category : Medical
Languages : en
Pages : 486

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Book Description
An understanding of the complex workings of the immune system is essential for all surgeons. Immune responses play a crucial part in the way human body reacts to infection and trauma. Immunology for Surgeons contains a high-level discussion of this difficult clinical area. The text looks at tumor immunobiology and immunotherapy as well as the worldwide results of various clinical trials. The topics discussed focus on relevant immunological and molecular biological trends for future treatment of complex surgical disease. The main objective of the text is to render a difficult area accessible for the postgraduate surgical trainee and established surgeon who is interested in immunology.

Author: Anthony Chang
Publisher: Elsevier Health Sciences
ISBN: 0443250308
Category : Medical
Languages : en
Pages : 611

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Book Description
This volume in the Diagnostic Pathology series is an ideal point-of-care resource for practitioners at all levels of experience and training. Covering the full range of solid organ transplantation (SOT) of the kidney, liver, heart, lung, pancreas, intestine, and more, it provides a current understanding of transplant immunology and pathology to help ensure accurate diagnosis for optimal clinical management. Richly illustrated and easy to use, Diagnostic Pathology: Transplant Pathology, third edition, is a visually stunning, one-stop reference for practicing pathologists, transplant practitioners, and students of organ transplantation. - Covers all areas of transplant pathology, incorporating the collective knowledge and experience from a team of transplant pathology experts with the latest updates from the 2022 Banff classification - Groups content by specific organ transplant, including kidney, liver, heart, lung, intestine, pancreas, and vascularized composite allotransplantation - Features sweeping updates throughout, including new chapters on transplant immunology that cover chronic viral infections and the immune response, immune manipulation and accommodation, and graft-vs.-host disease - Contains a new chapter on islet cell transplantation and new, detailed information on xenotransplantation—specifically kidney xenograft - Covers advances in vascularized composite allografts (hands, face, uterus, phallus) transplantation - Features more than 1,500 superb images, including histology, gross pathology, full-color illustrations, and radiologic images - Employs consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of care - Any additional digital ancillary content may publish up to 6 weeks following the publication date

Author: David K. C. Cooper
Publisher: Springer Nature
ISBN: 3030491277
Category : Medical
Languages : en
Pages : 313

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Book Description
This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.

Author: Kenneth L. Franco
Publisher: PMPH-USA
ISBN: 9781550090802
Category : Medical
Languages : en
Pages : 568

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Book Description
Summarizes many of the advances made in this area and reviews in depth the topics and treatment techniques not widely used in daily practice. New chapters to this second edition include: New Techniques to Manage Pain; Advances in Diagnostic Imaging; Management of Germ Cell Tumors of the Mediastinum, Updates on Diaphragmatic Pacing; and Preoperative Evaluation of Neuro-Motor Diseases of the Esophagus.