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Author: H. Wagner Publisher: Springer Science & Business Media ISBN: 364259672X Category : Medical Languages : en Pages : 249
Book Description
Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
Author: H. Wagner Publisher: Springer Science & Business Media ISBN: 364259672X Category : Medical Languages : en Pages : 249
Book Description
Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
Author: H Wagner Publisher: ISBN: 9783642596735 Category : Antigen presenting cells Languages : en Pages : 264
Book Description
Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
Author: Eyal Raz Publisher: Springer Science & Business Media ISBN: 1592593054 Category : Science Languages : en Pages : 397
Book Description
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Author: E. Raz Publisher: Springer Science & Business Media ISBN: 3642568661 Category : Medical Languages : en Pages : 202
Book Description
This volume is a product of a collaborative effort and attempts to provide a wide and up-to-date coverage of information regarding the biology and on the potential application of immunostimulatory DNA. ISS hold great promise for influencing the immune response and the authors anticipate that the high efficacy and low toxicity observed in animal models will translate into success in a variety of human clinical applications.
Author: Hermann Wagner Publisher: ISBN: Category : Antigen presenting cells Languages : de Pages : 268
Book Description
Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
Author: Ken J. Ishii Publisher: CRC Press ISBN: 1420068261 Category : Medical Languages : en Pages : 304
Book Description
Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation
Author: Eyal Raz Publisher: ISBN: 9781468497274 Category : Languages : en Pages : 428
Book Description
The immunostimulatory prospects of bacterial DNA have attracted the interest and attention of scientists and physicians and become a major focus in immunobiology and biomedicine. These activities are the product of immunostimulatory DNA sequences (ISS, also known as GpG motifs), which are rare in the mammalian genome. ISS were shown to enhance immunological responses and were used to confer protection to a wide variety of tumors, allergic inflammation, and infections. In Microbial DNA and Host Immunity, leading researchers review the activation of the mammalian immune system by bacterial DNA and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS, the process of cell activation, and potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis). Up-to-date and informative, Microbial DNA and Host Immunity illuminates the immunobiology of bacterial DNA and its promise of powerful new vaccines to provide protective immunity against infections, tumors, and chronic disease.
Author: Stefan Bauer Publisher: Springer Science & Business Media ISBN: 3540721673 Category : Medical Languages : en Pages : 243
Book Description
Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Author: Publisher: ISBN: Category : Languages : en Pages :
Book Description
Bacterial DNA as well as synthetic singlestranded CpG-DNA oligonucleotides displaying unmethylated CpG motifs activate the vertebrate immune system. Upon engaging toll-like receptor 9 CpG-DNA triggers potent Th1-based immune responses characterized by generation of cytotoxic T lymphocytes (CTL), certain cytokines and antibody subclasses. Here we demonstrate that by covalently linking antigen and CpG-DNA antigen is efficiently directed into intracellular compartments of antigen presenting cells resulting in activation, increased cross-presentation of antigen-derived peptides and thus enhanced induction of antigen-specific CTL responses in vivo. Hence, linked CpG-DNA fulfils a dual role: shutteling antigen-uptake and mediating antigen-specific activation. Since conjugation to stimulatory DNA reduces allergenicity, yet improves immunogenicity of complexed antigens, these conjugates could yield therapeutic potential in vaccine strategies against cancer, allergy or infectious diseases.
Author: H. Wagner
Author: H. Wagner
Author: H Wagner
Author: Eyal Raz
Author: E. Raz
Author: Hermann Wagner
Author: Ken J. Ishii
Author: Eyal Raz
Author: 
Author: Stefan Bauer
Author: