Immunology of Recurrent Pregnancy Loss and Implantation Failure PDF Download

Author: Joanna Kwak-Kim
Publisher: Elsevier
ISBN: 0323908055
Category : Medical
Languages : en
Pages : 456

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Book Description
Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease. Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information. In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches. Provides detailed immunological background for understanding the etiology and management of reproduction failure Evaluates various immunological factors involved in the pathogenesis and management of reproduction failure Gives insights into various immunological and therapeutic approaches for reproduction failure

Author: Udo R. Markert
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805579705
Category : Medical
Languages : en
Pages : 201

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Book Description
This book presents the discipline of immunology which studies a unique physiological phenomenon contradicting many of the generally established rules in the field: immunology of pregnancy. It provides a wide overview of the current research of this topic. Prominent and leading international groups contributed by reviewing the most significant findings in the field.

Author: Keiji Kuroda
Publisher: Springer
ISBN: 9811086907
Category : Medical
Languages : en
Pages : 125

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Book Description
This book offers a highly informative guide to treating unexplained infertility and recurrent miscarriage (RM). In particular, it provides detailed treatment strategies for infertility or RM derived from uterine circumstance such as chronic endometritis and perturbation of endometrial decidualization, as well as maternal immunological rejection of an embryo as semi-allograft. Unexplained infertility refers to those types that cannot be detected by the general screening test. The causes are sometimes detected in the course of treatment with assisted reproductive technology including IVF. However, some unexplained infertility is intractable even after intracytoplasmic sperm injection or repeated implantation of morphologically suitable embryos. Patients with unexplained RM also have a high likelihood of undetectable risk factors of miscarriage. As a result, gynecologists often repeatedly provide these couples with general treatments for infertility and miscarriage or even discontinue treatment because they cannot detect the reason, which places serious financial, physical and mental burdens on the couples affected. This book offers gynecologists essential insights into the pathological condition of unexplained infertility and RM, equipping them to identify it, explain it to patients, and consider further examinations and more aggressive fertility treatments.

Author: Gendie Lash
Publisher: Frontiers Media SA
ISBN: 2832539793
Category : Medical
Languages : en
Pages : 119

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Book Description
Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses before the 20th week of gestation, occuring in 1%–3% of reproductive women. Unexplained RPL (URPL) is a heterogeneous condition affecting approximately 50% of RPL cases, with one contributing factor thought to be a disruption in maternal immune tolerance. Various immune effectors and molecules in the immune-microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus during pregnancy. Immune cells including innate lymphoid cells (ILCs), myeloid cells, T cells and B cells have been found to contribute to maintaining this maternal immunological tolerance during pregnancy. ILCs have been found to be the most abundant immune cells in the pregnant uterus, with many studies focusing on the relationship between RPL and either T cells or natural killer (NK) cells in peripheral blood and the endometrium/decidua. Despite progress in uncovering the roles of NK, and regulatory T cells and cytokines in pregnancy, the immune heterogeneity in patients with URPL remains elusive.

Author: Robert L. Coffman
Publisher: Springer Science & Business Media
ISBN: 3662097095
Category : Medical
Languages : en
Pages : 158

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Book Description
The two major subsets of CD4+ helper T cells, designated Th1 and Th2, have quite different patterns of cytokine production and, as a consequence, have very different roles in immune responses. The articles in this volume review both basic and clinical studies of T cell heterogeneity, including: the mechanisms by which Th1 and Th2 cells develop and maintain their differences in cytokine production; the different roles of Th1 and Th2 cells in allergy, autoimmunity and infectious diseases; the prospects and strategies for therapeutic manipulation of Th1 and Th2 cells; and the control of Th1 and Th2 responses by regulatory T cell subsets. The volume should give the reader a view of the development and function of Th1 and Th2 cells and the attempts to treat immunological diseases with therapies directed towards altering the Th1/Th2 balance.

Author: Howard Carp
Publisher: CRC Press
ISBN: 1482216159
Category : Medical
Languages : en
Pages : 444

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Book Description
Recurrent pregnancy loss presents a vexing clinical problem primarily for medical professionals treating patients in reproductive medicine and in maternal-fetal medicine. However, with its numerous causes and various suggested treatment options, the problem is more multidisciplinary in nature, involving gynecology, genetics, endocrinology, immunolo

Author: Eric J. Bieber
Publisher: Cambridge University Press
ISBN: 1107040396
Category : Medical
Languages : en
Pages : 1127

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Book Description
Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

Author: Anthony Carter
Publisher: Boydell & Brewer
ISBN: 9781580460439
Category : Medical
Languages : en
Pages : 456

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Book Description
The 29 papers contained in this volume look closely at various aspects of what is termed, "The Maternal-Fetal Interface," as it relates to the latest research in placental science. A substantial section of the book is devoted to the troublesome question of vertical transmission of infectious agents: namely, the HIV-1 virus. However, other sections of the volume examine related issues such as drug and toxin transfer across the term placenta and the diversity of placental types and how this can affect a placenta's effectiveness as a barrier. Anthony Carter is at the University of Odense, Denmark Vibeke Dantzer is at the University of Copenhagen, DenmarkThomas Jansson is at the University of Gothenburg, Sweden

Author: Andrea Dunaif
Publisher: Springer Science & Business Media
ISBN: 1597451088
Category : Medical
Languages : en
Pages : 361

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Book Description
This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.

Author: Gil Mor
Publisher: Academic Press
ISBN: 0128189304
Category : Medical
Languages : en
Pages : 462

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Book Description
Reproductive Immunology: Basic Concepts gives a holistic insight into the understanding of the complex interactions between the maternal immune system and the fetal/placental unit necessary for the success of pregnancy. This interaction is critical for the support of the human fetal semiallograft and the protection against infections. The book covers various topics such as B cells, macrophages, T cells, discussion on fetal signals and their impact on maternal reproductive cells such as endometrial cells, mast cells, and the role of fetal Hofbauer cells, the immune regulatory role of glucorticoids, and many other novel topics within the field of reproductive immunology. Edited and written by experts in the field, this book introduces the up-to-date knowledge of the role of the immune system during pregnancy and provides the necessary background to understand pregnancy complications associated with alterations in the functioning of the immune system. The book provides a complete discussion on the immunological aspects of pregnancy and serves as a great tool for research scientists, students, reproductive immunologists and OBGYNs. - Shows the detailed evaluation of the knowledge related to each immune cell type in the pregnant and not pregnant uterus - Evaluates each immune cell type and its function during specific reproductive events - Provides the biological background for understanding the clinical aspects that will be discussed in subsequent volumes in the series