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Author: Edythe D. London Publisher: Routledge ISBN: 1351439332 Category : Medical Languages : en Pages : 444
Book Description
Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.
Author: Edythe D. London Publisher: Routledge ISBN: 1351439332 Category : Medical Languages : en Pages : 444
Book Description
Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.
Author: Philip Seeman Publisher: Elsevier ISBN: 012418684X Category : Science Languages : en Pages : 534
Book Description
Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease
Author: Edythe D. London Publisher: Routledge ISBN: 1351439340 Category : Medical Languages : en Pages : 432
Book Description
Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.
Author: Cameron S. Carter Publisher: Springer Science & Business Media ISBN: 3642287115 Category : Medical Languages : en Pages : 395
Book Description
This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer’s disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.
Author: Anat Biegon Publisher: CRC Press ISBN: 9780849376535 Category : Medical Languages : en Pages : 202
Book Description
Sites of Drug Action in the Human Brain uses the results of recent analyses of the regional brain distribution and binding pattern of drugs in the human brain. This new book specifically addresses drugs of abuse and treats the effects of various drugs on behavior and mood, as well as on metabolism and blood flow in the human brain. It also presents the methodological aspects of investigating the sites of drug action in the human brain. Because it focuses on the living human brain, this book differs from other books on the subject, which primarily use the results of postmortem studies. Sites of Drug Action in the Human Brain therefore provides valuable information on the clinical aspects of drug intoxification, addiction, and toxicity.
Author: Li Di Publisher: John Wiley & Sons ISBN: 1118788354 Category : Medical Languages : en Pages : 604
Book Description
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
Author: Harry Chugani, MD Publisher: Oxford University Press ISBN: 0199711526 Category : Medical Languages : en Pages :
Book Description
Perhaps the most important achievements in the field of epileptology in the past two decades have been in the neuroimaging and genetic breakthroughs as applied to patients with epilepsy. Indeed, neuroimaging has become a vital part in the study of epilepsy, affecting broad aspects of the disorder ranging from diagnosis and classification to treatment and prognosis. Neuroimaging in epilepsy encompasses many different approaches that have reached various levels of expertise across epilepsy centers worldwide. This book discusses every imaging modality used to gather information on epilepsy. Each technique is described by world experts and epilepsy centers worldwide.
Author: David Borsook Publisher: Oxford University Press, USA ISBN: 019975456X Category : Health & Fitness Languages : en Pages : 400
Book Description
The Migraine Brain provides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches.
Author: Elke Hattingen Publisher: Springer ISBN: 3642450407 Category : Medical Languages : en Pages : 166
Book Description
This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Author: Lawrence Kruger Publisher: CRC Press ISBN: 1439812101 Category : Health & Fitness Languages : en Pages : 458
Book Description
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical
Author: Edythe D. London
Author: Edythe D. London
Author: Philip Seeman
Author: Edythe D. London
Author: Cameron S. Carter
Author: Anat Biegon
Author: Li Di
Author: Harry Chugani, MD
Author: David Borsook
Author: Elke Hattingen
Author: Lawrence Kruger