Identification of Novel Genes Required for Proper Chromosome Segregation in Drosophila Melanogaster PDF Download

Author: Carin Cass Zimmerman
Publisher:
ISBN:
Category :
Languages : en
Pages : 338

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Author: Lisa Messina
Publisher:
ISBN:
Category :
Languages : en
Pages : 120

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Author: Mia Daniele Champion
Publisher:
ISBN:
Category :
Languages : en
Pages : 330

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Author: Hao Liu
Publisher:
ISBN:
Category :
Languages : en
Pages : 270

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Author: Michael James Denham White
Publisher: CUP Archive
ISBN: 9780521070713
Category : Science
Languages : en
Pages : 976

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Chromosomes as supermolecular systems; The mitotic mechanism in evolution Endomitosis and endopolyploidy; Giant chromosomes the polytene type; Giant chromosomes the lampbrush type; The mechanism of meiosis; Chromosomes rearrangements occourrence and mechanisms; Chromosomal polymorphism in natural populations; Supernumerary chromosomes; Chromosomal rearrangements and speciaton evolution of the meiotic mechanism. The evolution of aberrant genetic systems; The cytology of interspecific hybrid;. The evolution of sex determination; Haplodiploidy; Thelytoky.

Author: William Sullivan
Publisher: CSHL Press
ISBN: 9780879695866
Category : Medical
Languages : en
Pages : 798

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Book Description
This exceptional laboratory manual describes thirty-seven procedures most likely to be used in the next decade for molecular, biochemical, and cellular studies on Drosophila. They were selected after extensive consultation with the research community and rigorously edited for clarity, uniformity, and conciseness.The methods included permit investigation of chromosomes, cell biology, molecular biology, genomes, biochemistry, and development. Each protocol includes the basic information needed by novices, with sufficient detail to be valuable to experienced investigators. Each method is carefully introduced and illustrated with figures, tables, illustrations, and examples of the data obtainable. The book's appendices include key aspects of Drosophila biology, essential solutions, buffers, and recipes.An evolution of Michael Ashburner's 1989 classic Drosophila: A Laboratory Manual, this book is an essential addition to the personal library of Drosophila investigators and an incomparable resource for other research groups with goals likely to require fly-based technical approaches.

Author: Ralf Kühn
Publisher: Humana Press
ISBN: 9781934115268
Category : Science
Languages : en
Pages : 0

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Following the completion of the mouse and human genome sequences, a major challengeisthefunctionalcharacterizationofeverymammaliangeneandthedeciph- ing of their molecular interaction network. The mouse offers many advantages for the use of genetics to study human biology and disease, unmatched among other m- mals. Its development, body plan, physiology, behavior, and diseases have much in common, based on the fact that 99% of the human genes have a mouse ortholog. The investigation of gene function using mouse models is based on many years of tech- logical development. In the two decades since gene targeting in murine embryonic stem (ES) cells was first described by Mario Capecchi and colleagues, more than 3000 predesigned mouse mutants have been developed. To date, a variety of mouse mutagenesis techniques, either gene- or phenotype-driven, are used as systematic approaches. The availability of the genome sequence supports gene-driven approaches such as gene-trap and targeted mutagenesis in ES cells, allowing efficient and precise gene disruption. In combination with the use of site-specific DNA recombinases, in particular the Cre/loxP system, gene disruptioncan be directed to specific cell types in conditionalmousemutants. Furthermore,chemicalandtransposonmutagenesisofthe mouse genome enables us to perform phenotype-driven screens for the unbiased identification of phenotype–genotype correlations involved in models of human d- ease. Over the next several years, the mouse genome will be systematically altered, and the techniques for achieving predesigned manipulations will be constantly developed further and improved. The second edition of Gene Knockout Protocols brings together distinguished c- tributorswithextensiveexperienceinthegenetargetingandmousegeneticsfields.

Author: Marcelo Larramendy
Publisher: BoD – Books on Demand
ISBN: 9535134736
Category : Medical
Languages : en
Pages : 206

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This edited book, Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability, contains a series of chapters highlighting several aspects related to the generation of chromosomal abnormalities in genetic material. We are extremely grateful to the authors who had contributed with valuable information about the role of genomic instability in pathological disorders as well as in the evolution process.

Author: Ralph J. Greenspan
Publisher: CSHL Press
ISBN: 9780879697112
Category : Science
Languages : en
Pages : 212

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Book Description
A second edition of the classic handbook has become a standard in the Drosophila field. This edition is expanded to include topics in which classical genetic strategies have been augmented with new molecular tools. Included are such new techniques as homologous recombination, RNAi, new mapping techniques, and new mosaic marking techniques.

Author: Peter De Wulf
Publisher: Springer Science & Business Media
ISBN: 038769076X
Category : Medical
Languages : en
Pages : 516

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Book Description
Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. “The Kinetochore: from Molecular Discoveries to Cancer Therapy” presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and “model” eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.